lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2693
Symbol	GHSR
Synonymous	GHDP
Full name	growth hormone secretagogue receptor
Gene description	GH-releasing peptide receptor\|GHRP\|GHS-R\|ghrelin receptor\|growth hormone secretagogue receptor type 1
Cytoband	3q26.31
Gene type	protein-coding
Synonymous	MIM:601898; HGNC:HGNC:4267; Ensembl:ENSG00000121853; HPRD:03541; Vega:OTTHUMG00000156946

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.10G>A; p.A4T; 3:172448404-172448404	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.207G>T; p.S69S; 3:172448207-172448207	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.76G>A; p.G26S; 3:172448338-172448338	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.841G>A; p.V281I; 3:172445421-172445421	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>A; p.A59T; 3:172448239-172448239	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.72C>T; p.S24S; 3:172448342-172448342	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.72C>T; p.S24S; 3:172448342-172448342	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1064G>T; p.S355I; 3:172445198-172445198	prostate	carcinoma	Substitution - Missense
c.747G>T; p.V249V; 3:172447667-172447667	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.151G>A; p.V51M; 3:172448263-172448263	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.36C>G; p.F12L; 3:172448378-172448378	urinary_tract; bladder	carcinoma	Substitution - Missense
c.435C>G; p.I145M; 3:172447979-172447979	oesophagus	carcinoma	Substitution - Missense
c.429C>T; p.F143F; 3:172447985-172447985	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.150C>T; p.C50C; 3:172448264-172448264	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.319C>T; p.R107W; 3:172448095-172448095	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.615G>A; p.V205V; 3:172447799-172447799	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.477G>A; p.R159R; 3:172447937-172447937	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.642G>A; p.V214V; 3:172447772-172447772	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.537C>T; p.F179F; 3:172447877-172447877	skin	malignant_melanoma	Substitution - coding silent
c.537C>T; p.F179F; 3:172447877-172447877	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.964C>A; p.L322M; 3:172445298-172445298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1057G>T; p.D353Y; 3:172445205-172445205	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.902G>A; p.S301N; 3:172445360-172445360	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.94G>A; p.D32N; 3:172448320-172448320	pancreas	carcinoma	Substitution - Missense
c.918C>T; p.L306L; 3:172445344-172445344	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.236A>G; p.N79S; 3:172448178-172448178	skin	malignant_melanoma	Substitution - Missense
c.180C>T; p.G60G; 3:172448234-172448234	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1016G>A; p.G339E; 3:172445246-172445246	skin	malignant_melanoma	Substitution - Missense
c.731G>A; p.R244H; 3:172447683-172447683	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.40C>T; p.L14F; 3:172448374-172448374	large_intestine; colon	NS	Substitution - Missense
c.820C>A; p.L274I; 3:172445442-172445442	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.731G>A; p.R244H; 3:172447683-172447683	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.820C>A; p.L274I; 3:172445442-172445442	breast	carcinoma	Substitution - Missense
c.337G>A; p.D113N; 3:172448077-172448077	skin	malignant_melanoma	Substitution - Missense
c.144C>T; p.A48A; 3:172448270-172448270	thyroid	other; neoplasm	Substitution - coding silent
c.264C>T; p.S88S; 3:172448150-172448150	skin	malignant_melanoma	Substitution - coding silent
c.663C>T; p.F221F; 3:172447751-172447751	thyroid	other; neoplasm	Substitution - coding silent
c.400A>T; p.I134F; 3:172448014-172448014	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.122C>T; p.P41L; 3:172448292-172448292	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.535T>A; p.F179I; 3:172447879-172447879	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.131C>T; p.A44V; 3:172448283-172448283	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.347G>T; p.C116F; 3:172448067-172448067	thyroid	other; neoplasm	Substitution - Missense
c.894T>A; p.A298A; 3:172445368-172445368	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.959C>A; p.P320H; 3:172445303-172445303	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.640G>A; p.V214M; 3:172447774-172447774	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.441C>A; p.F147L; 3:172447973-172447973	skin	malignant_melanoma	Substitution - Missense
c.350A>T; p.K117I; 3:172448064-172448064	thyroid	other; neoplasm	Substitution - Missense
c.713A>G; p.K238R; 3:172447701-172447701	skin	malignant_melanoma	Substitution - Missense
c.882C>T; p.S294S; 3:172445380-172445380	skin	malignant_melanoma	Substitution - coding silent
c.106C>T; p.Q36*; 3:172448308-172448308	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.214C>T; p.R72C; 3:172448200-172448200	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.270G>T; p.L90L; 3:172448144-172448144	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.722G>A; p.R241Q; 3:172447692-172447692	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.453C>T; p.A151A; 3:172447961-172447961	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.604G>A; p.E202K; 3:172447810-172447810	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.971A>C; p.N324T; 3:172445291-172445291	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.635T>C; p.V212A; 3:172447779-172447779	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.R102C; 3:172448110-172448110	skin	malignant_melanoma	Substitution - Missense
c.304C>T; p.R102C; 3:172448110-172448110	skin	malignant_melanoma	Substitution - Missense
c.495C>T; p.F165F; 3:172447919-172447919	skin	malignant_melanoma	Substitution - coding silent
c.745G>A; p.V249M; 3:172447669-172447669	central_nervous_system; brain	glioma	Substitution - Missense
c.425A>T; p.Y142F; 3:172447989-172447989	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.425A>T; p.Y142F; 3:172447989-172447989	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.408G>A; p.A136A; 3:172448006-172448006	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.63G>A; p.W21*; 3:172448351-172448351	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.408G>A; p.A136A; 3:172448006-172448006	prostate	carcinoma	Substitution - coding silent
c.664_666delTTC; p.F222delF; 3:172447748-172447750	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.108G>A; p.Q36Q; 3:172448306-172448306	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.585C>T; p.T195T; 3:172447829-172447829	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.647T>C; p.V216A; 3:172447767-172447767	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.73C>T; p.P25S; 3:172448341-172448341	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1026C>A; p.P342P; 3:172445236-172445236	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.597C>A; p.R199R; 3:172447817-172447817	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.447C>G; p.L149L; 3:172447967-172447967	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.202G>A; p.V68M; 3:172448212-172448212	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.417C>T; p.V139V; 3:172447997-172447997	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.511G>A; p.A171T; 3:172447903-172447903	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.611C>T; p.A204V; 3:172447803-172447803	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.596G>A; p.R199H; 3:172447818-172447818	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.334G>A; p.G112S; 3:172448080-172448080	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.75C>T; p.P25P; 3:172448339-172448339	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.273C>T; p.L91L; 3:172448141-172448141	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1026C>T; p.P342P; 3:172445236-172445236	skin	malignant_melanoma	Substitution - coding silent
c.81C>T; p.N27N; 3:172448333-172448333	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.984G>T; p.K328N; 3:172445278-172445278	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.616C>T; p.R206C; 3:172447798-172447798	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.430G>A; p.A144T; 3:172447984-172447984	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.730C>T; p.R244C; 3:172447684-172447684	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.249C>T; p.S83S; 3:172448165-172448165	thyroid	other; neoplasm	Substitution - coding silent
c.131_144del14; p.A44fs*76; 3:172448270-172448283	prostate	carcinoma	Deletion - Frameshift
c.71C>T; p.S24F; 3:172448343-172448343	skin	malignant_melanoma	Substitution - Missense
c.958C>T; p.P320S; 3:172445304-172445304	skin	malignant_melanoma	Substitution - Missense
c.595C>T; p.R199C; 3:172447819-172447819	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.364G>A; p.V122I; 3:172448050-172448050	breast	carcinoma	Substitution - Missense
c.587A>T; p.N196I; 3:172447827-172447827	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.30G>T; p.P10P; 3:172448384-172448384	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.293T>C; p.L98P; 3:172448121-172448121	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.705C>T; p.I235I; 3:172447709-172447709	liver	carcinoma	Substitution - coding silent
c.705C>T; p.I235I; 3:172447709-172447709	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.705C>T; p.I235I; 3:172447709-172447709	liver	carcinoma	Substitution - coding silent
c.558C>T; p.H186H; 3:172447856-172447856	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.413G>A; p.S138N; 3:172448001-172448001	skin	malignant_melanoma	Substitution - Missense
c.571G>T; p.D191Y; 3:172447843-172447843	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.602C>T; p.T201I; 3:172447812-172447812	skin	malignant_melanoma	Substitution - Missense
c.1066T>C; p.S356P; 3:172445196-172445196	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.344T>C; p.L115P; 3:172448070-172448070	thyroid	other; neoplasm	Substitution - Missense
c.564C>T; p.N188N; 3:172447850-172447850	pancreas	carcinoma	Substitution - coding silent
c.564C>T; p.N188N; 3:172447850-172447850	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.183C>G; p.N61K; 3:172448231-172448231	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1001T>G; p.V334G; 3:172445261-172445261	NS	malignant_melanoma	Substitution - Missense
c.205T>A; p.S69T; 3:172448209-172448209	breast	carcinoma	Substitution - Missense
c.710G>A; p.R237K; 3:172447704-172447704	skin	malignant_melanoma	Substitution - Missense
c.224G>A; p.R75H; 3:172448190-172448190	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>T; p.P177P; 3:172447883-172447883	skin	malignant_melanoma	Substitution - coding silent
c.686C>T; p.T229M; 3:172447728-172447728	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.634G>A; p.V212I; 3:172447780-172447780	skin	malignant_melanoma	Substitution - Missense
c.687G>A; p.T229T; 3:172447727-172447727	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.687G>A; p.T229T; 3:172447727-172447727	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.755C>T; p.S252L; 3:172447659-172447659	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.919G>A; p.V307M; 3:172445343-172445343	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.207G>A; p.S69S; 3:172448207-172448207	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.207G>A; p.S69S; 3:172448207-172448207	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.207G>A; p.S69S; 3:172448207-172448207	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.207G>A; p.S69S; 3:172448207-172448207	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.567C>A; p.G189G; 3:172447847-172447847	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.285C>A; p.C95*; 3:172448129-172448129	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.171C>T; p.G57G; 3:172448243-172448243	thyroid	other; neoplasm	Substitution - coding silent
c.629T>A; p.L210H; 3:172447785-172447785	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.734G>A; p.G245D; 3:172447680-172447680	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.358C>T; p.Q120*; 3:172448056-172448056	thyroid	other; neoplasm	Substitution - Nonsense
c.1073C>T; p.A358V; 3:172445189-172445189	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.546C>T; p.V182V; 3:172447868-172447868	stomach	adenocarcinoma	Substitution - coding silent
c.132G>A; p.A44A; 3:172448282-172448282	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.867C>T; p.S289S; 3:172445395-172445395	skin	malignant_melanoma	Substitution - coding silent
c.903C>A; p.S301R; 3:172445359-172445359	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.351A>T; p.K117N; 3:172448063-172448063	thyroid	other; neoplasm	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation