lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	267
Symbol	AMFR
Synonymous	GP78\|RNF45
Full name	autocrine motility factor receptor, E3 ubiquitin protein ligase
Gene description	E3 ubiquitin-protein ligase AMFR\|RING finger protein 45
Cytoband	16q21
Gene type	protein-coding
Synonymous	MIM:603243; HGNC:HGNC:463; Ensembl:ENSG00000159461; HPRD:09130; Vega:OTTHUMG00000133239

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1517G>A; p.R506Q; 16:56367526-56367526	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1258C>A; p.H420N; 16:56389203-56389203	skin	malignant_melanoma	Substitution - Missense
c.1490G>A; p.R497Q; 16:56369218-56369218	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1183C>T; p.Q395*; 16:56389278-56389278	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1850C>T; p.A617V; 16:56362991-56362991	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1228G>A; p.E410K; 16:56389233-56389233	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1172G>T; p.R391M; 16:56389289-56389289	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.38G>T; p.S13I; 16:56425290-56425290	thyroid	other; neoplasm	Substitution - Missense
c.1599+4A>G; p.?; 16:56367440-56367440	breast	carcinoma; ductal_carcinoma	Unknown
c.1623C>G; p.L541L; 16:56364082-56364082	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.895C>T; p.R299C; 16:56403064-56403064	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.764C>T; p.T255M; 16:56404985-56404985	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.764C>T; p.T255M; 16:56404985-56404985	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1508C>A; p.P503H; 16:56369200-56369200	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1133G>A; p.C378Y; 16:56389328-56389328	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.348+1G>C; p.?; 16:56414251-56414251	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.525G>A; p.S175S; 16:56408105-56408105	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1273G>A; p.D425N; 16:56389188-56389188	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.328C>G; p.L110V; 16:56414272-56414272	pancreas	carcinoma	Substitution - Missense
c.328C>G; p.L110V; 16:56414272-56414272	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.328C>G; p.L110V; 16:56414272-56414272	pancreas	carcinoma	Substitution - Missense
c.328C>G; p.L110V; 16:56414272-56414272	pancreas	carcinoma	Substitution - Missense
c.1378A>C; p.M460L; 16:56385921-56385921	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.954G>A; p.V318V; 16:56403005-56403005	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.944A>G; p.Y315C; 16:56403015-56403015	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.944A>G; p.Y315C; 16:56403015-56403015	liver	carcinoma	Substitution - Missense
c.944A>G; p.Y315C; 16:56403015-56403015	liver	carcinoma	Substitution - Missense
c.944A>G; p.Y315C; 16:56403015-56403015	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.713T>C; p.V238A; 16:56405036-56405036	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1097G>C; p.R366P; 16:56389364-56389364	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1097G>C; p.R366P; 16:56389364-56389364	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.524C>T; p.S175L; 16:56408106-56408106	central_nervous_system; brain	glioma	Substitution - Missense
c.1787G>A; p.R596H; 16:56363054-56363054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1259A>C; p.H420P; 16:56389202-56389202	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1710C>T; p.R570R; 16:56363995-56363995	large_intestine; rectum	NS	Substitution - coding silent
c.1080C>T; p.F360F; 16:56401738-56401738	skin	malignant_melanoma	Substitution - coding silent
c.1695G>T; p.E565D; 16:56364010-56364010	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1923G>T; p.Q641H; 16:56362918-56362918	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.923G>A; p.R308Q; 16:56403036-56403036	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1780C>T; p.R594C; 16:56363925-56363925	skin	malignant_melanoma	Substitution - Missense
c.981A>C; p.A327A; 16:56401837-56401837	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.323G>C; p.G108A; 16:56414277-56414277	skin	malignant_melanoma	Substitution - Missense
c.1863C>T; p.P621P; 16:56362978-56362978	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.358G>T; p.D120Y; 16:56409579-56409579	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1010A>G; p.N337S; 16:56401808-56401808	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1419C>A; p.Y473*; 16:56369289-56369289	liver	carcinoma	Substitution - Nonsense
c.1419C>A; p.Y473*; 16:56369289-56369289	liver	carcinoma	Substitution - Nonsense
c.1397A>G; p.E466G; 16:56369311-56369311	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1771C>T; p.Q591*; 16:56363934-56363934	skin	malignant_melanoma	Substitution - Nonsense
c.1669G>T; p.E557*; 16:56364036-56364036	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1846G>T; p.G616C; 16:56362995-56362995	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.256-1G>T; p.?; 16:56414345-56414345	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.949C>T; p.R317C; 16:56403010-56403010	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1333A>G; p.N445D; 16:56385966-56385966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1259A>G; p.H420R; 16:56389202-56389202	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.798C>T; p.L266L; 16:56404951-56404951	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.928C>T; p.R310C; 16:56403031-56403031	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.928C>T; p.R310C; 16:56403031-56403031	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.928C>T; p.R310C; 16:56403031-56403031	skin	malignant_melanoma	Substitution - Missense
c.1517G>T; p.R506L; 16:56367526-56367526	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1052C>T; p.A351V; 16:56401766-56401766	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1876C>T; p.R626*; 16:56362965-56362965	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1201G>A; p.E401K; 16:56389260-56389260	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1739G>A; p.R580H; 16:56363966-56363966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1166G>A; p.R389H; 16:56389295-56389295	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1271T>G; p.F424C; 16:56389190-56389190	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1408C>G; p.Q470E; 16:56369300-56369300	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.866T>C; p.M289T; 16:56403093-56403093	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1405C>T; p.P469S; 16:56369303-56369303	skin	malignant_melanoma	Substitution - Missense
c.1594G>A; p.A532T; 16:56367449-56367449	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1602C>T; p.T534T; 16:56364103-56364103	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1814A>T; p.D605V; 16:56363027-56363027	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.939G>T; p.K313N; 16:56403020-56403020	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1700G>A; p.R567H; 16:56364005-56364005	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.650C>T; p.A217V; 16:56407980-56407980	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.326C>G; p.P109R; 16:56414274-56414274	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1857T>C; p.S619S; 16:56362984-56362984	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1055G>A; p.R352Q; 16:56401763-56401763	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1380+1G>A; p.?; 16:56385918-56385918	stomach	carcinoma; adenocarcinoma	Unknown
c.1561C>T; p.P521S; 16:56367482-56367482	skin	malignant_melanoma	Substitution - Missense
c.958G>T; p.G320*; 16:56403001-56403001	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1060C>G; p.L354V; 16:56401758-56401758	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1860C>T; p.D620D; 16:56362981-56362981	central_nervous_system; brain	glioma	Substitution - coding silent
c.804C>T; p.L268L; 16:56404945-56404945	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1156G>A; p.D386N; 16:56389305-56389305	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1692C>T; p.F564F; 16:56364013-56364013	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation