lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2668
Symbol	GDNF
Synonymous	ATF1\|ATF2\|HFB1-GDNF\|HSCR3
Full name	glial cell derived neurotrophic factor
Gene description	ATF\|astrocyte-derived trophic factor\|glial cell line-derived neurotrophic factor
Cytoband	5p13.1-p12
Gene type	protein-coding
Synonymous	MIM:600837; HGNC:HGNC:4232; Ensembl:ENSG00000168621; HPRD:02906; Vega:OTTHUMG00000090809

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.308C>G; p.S103C; 5:37815979-37815979	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.98C>T; p.A33V; 5:37834699-37834699	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.328G>T; p.G110C; 5:37815959-37815959	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.278G>T; p.R93L; 5:37816009-37816009	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.278G>T; p.R93L; 5:37816009-37816009	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.529G>A; p.A177T; 5:37815758-37815758	pancreas	carcinoma	Substitution - Missense
c.500G>C; p.R167T; 5:37815787-37815787	urinary_tract; bladder	carcinoma	Substitution - Missense
c.500G>C; p.R167T; 5:37815787-37815787	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.447C>T; p.C149C; 5:37815840-37815840	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.447C>T; p.C149C; 5:37815840-37815840	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.175G>T; p.D59Y; 5:37816112-37816112	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.96C>T; p.P32P; 5:37834701-37834701	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.183C>T; p.F61F; 5:37816104-37816104	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.183C>T; p.F61F; 5:37816104-37816104	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.465G>A; p.T155T; 5:37815822-37815822	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.358T>G; p.L120V; 5:37815929-37815929	skin	malignant_melanoma	Substitution - Missense
c.572delT; p.L191fs*1; 5:37815715-37815715	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.51G>A; p.A17A; 5:37834746-37834746	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.284C>G; p.A95G; 5:37816003-37816003	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.464C>T; p.T155M; 5:37815823-37815823	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.379G>A; p.V127I; 5:37815908-37815908	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.379G>A; p.V127I; 5:37815908-37815908	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.487T>G; p.L163V; 5:37815800-37815800	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.487T>G; p.L163V; 5:37815800-37815800	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.487T>G; p.L163V; 5:37815800-37815800	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.225G>A; p.L75L; 5:37816062-37816062	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.97G>A; p.A33T; 5:37834700-37834700	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.605A>C; p.K202T; 5:37815682-37815682	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.335G>A; p.R112K; 5:37815952-37815952	skin	malignant_melanoma	Substitution - Missense
c.364G>C; p.A122P; 5:37815923-37815923	NS	NS	Substitution - Missense
c.468C>T; p.Y156Y; 5:37815819-37815819	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.259C>T; p.P87S; 5:37816028-37816028	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.298C>A; p.P100T; 5:37815989-37815989	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.426T>A; p.F142L; 5:37815861-37815861	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.357C>A; p.V119V; 5:37815930-37815930	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.253G>A; p.V85M; 5:37816034-37816034	skin	malignant_melanoma	Substitution - Missense
c.347_359del13; p.R116fs*6; 5:37815928-37815940	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.593A>G; p.H198R; 5:37815694-37815694	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.406A>G; p.T136A; 5:37815881-37815881	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.522A>G; p.V174V; 5:37815765-37815765	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.412G>A; p.E138K; 5:37815875-37815875	skin	malignant_melanoma	Substitution - Missense
c.190G>T; p.V64F; 5:37816097-37816097	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.137C>T; p.A46V; 5:37834660-37834660	liver	carcinoma	Substitution - Missense
c.137C>T; p.A46V; 5:37834660-37834660	liver	carcinoma	Substitution - Missense
c.176A>C; p.D59A; 5:37816111-37816111	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.478T>C; p.L160L; 5:37815809-37815809	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.466T>C; p.Y156H; 5:37815821-37815821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.128C>T; p.A43V; 5:37834669-37834669	urinary_tract; bladder	carcinoma	Substitution - Missense
c.416A>G; p.E139G; 5:37815871-37815871	large_intestine; colon	carcinoma	Substitution - Missense
c.416A>G; p.E139G; 5:37815871-37815871	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.308C>A; p.S103Y; 5:37815979-37815979	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.250G>T; p.A84S; 5:37816037-37816037	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.616A>G; p.K206E; 5:37815671-37815671	urinary_tract; bladder	carcinoma	Substitution - Missense
c.396G>A; p.L132L; 5:37815891-37815891	skin	malignant_melanoma	Substitution - coding silent
c.354T>A; p.C118*; 5:37815933-37815933	skin; extremity	malignant_melanoma	Substitution - Nonsense
c.431A>C; p.Y144S; 5:37815856-37815856	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.107G>A; p.R36H; 5:37834690-37834690	pancreas	carcinoma	Substitution - Missense
c.455C>T; p.A152V; 5:37815832-37815832	skin	malignant_melanoma	Substitution - Missense
c.249G>A; p.M83I; 5:37816038-37816038	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.491C>T; p.S164F; 5:37815796-37815796	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.459G>T; p.E153D; 5:37815828-37815828	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.439G>A; p.G147S; 5:37815848-37815848	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.350G>A; p.G117D; 5:37815937-37815937	haematopoietic_and_lymphoid_tissue; spleen	lymphoid_neoplasm; marginal_zone_lymphoma	Substitution - Missense
c.425T>G; p.F142C; 5:37815862-37815862	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.199T>G; p.F67V; 5:37816088-37816088	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.398G>T; p.G133V; 5:37815889-37815889	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.457G>A; p.E153K; 5:37815830-37815830	oesophagus	carcinoma	Substitution - Missense
c.63G>A; p.P21P; 5:37834734-37834734	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.126C>G; p.R42R; 5:37834671-37834671	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation