lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	25818
Symbol	KLK5
Synonymous	KLK-L2\|KLKL2\|SCTE
Full name	kallikrein-related peptidase 5
Gene description	kallikrein 5\|kallikrein-5\|kallikrein-like protein 2\|stratum corneum tryptic enzyme
Cytoband	19q13.33
Gene type	protein-coding
Synonymous	MIM:605643; HGNC:HGNC:6366; Ensembl:ENSG00000167754; HPRD:05732; Vega:OTTHUMG00000183097

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.74-9C>T; p.?; 19:50950125-50950125	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Unknown
c.382G>A; p.E128K; 19:50949069-50949069	skin	malignant_melanoma	Substitution - Missense
c.6T>C; p.A2A; 19:50952652-50952652	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.651C>T; p.C217C; 19:50948715-50948715	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.651C>T; p.C217C; 19:50948715-50948715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.490C>T; p.R164C; 19:50948961-50948961	skin	malignant_melanoma	Substitution - Missense
c.600C>T; p.F200F; 19:50948766-50948766	skin	malignant_melanoma	Substitution - coding silent
c.490C>T; p.R164C; 19:50948961-50948961	skin	malignant_melanoma	Substitution - Missense
c.490C>T; p.R164C; 19:50948961-50948961	breast	carcinoma	Substitution - Missense
c.490C>T; p.R164C; 19:50948961-50948961	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.600C>T; p.F200F; 19:50948766-50948766	skin	malignant_melanoma	Substitution - coding silent
c.490C>T; p.R164C; 19:50948961-50948961	skin	malignant_melanoma	Substitution - Missense
c.490C>T; p.R164C; 19:50948961-50948961	skin	malignant_melanoma	Substitution - Missense
c.490C>T; p.R164C; 19:50948961-50948961	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.264C>T; p.P88P; 19:50949926-50949926	skin	malignant_melanoma	Substitution - coding silent
c.665C>T; p.P222L; 19:50948701-50948701	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.176G>A; p.R59Q; 19:50950014-50950014	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.109C>A; p.H37N; 19:50950081-50950081	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.779C>T; p.S260F; 19:50943734-50943734	skin	malignant_melanoma	Substitution - Missense
c.779C>T; p.S260F; 19:50943734-50943734	skin	malignant_melanoma	Substitution - Missense
c.812G>A; p.R271K; 19:50943701-50943701	skin	malignant_melanoma	Substitution - Missense
c.464T>C; p.M155T; 19:50948987-50948987	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.69C>T; p.V23V; 19:50952589-50952589	skin	malignant_melanoma	Substitution - coding silent
c.118A>C; p.N40H; 19:50950072-50950072	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.138C>T; p.S46S; 19:50950052-50950052	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.138C>T; p.S46S; 19:50950052-50950052	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.758G>C; p.G253A; 19:50943755-50943755	pancreas	carcinoma	Substitution - Missense
c.881G>C; p.*294S; 19:50943632-50943632	oesophagus	carcinoma; adenocarcinoma	Nonstop extension
c.420C>T; p.I140I; 19:50949031-50949031	skin	malignant_melanoma	Substitution - coding silent
c.32T>G; p.V11G; 19:50952626-50952626	skin	malignant_melanoma	Substitution - Missense
c.166G>A; p.E56K; 19:50950024-50950024	NS	malignant_melanoma	Substitution - Missense
c.800C>T; p.A267V; 19:50943713-50943713	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>T; p.G243C; 19:50943786-50943786	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.687G>A; p.M229I; 19:50948679-50948679	ovary	other; neoplasm	Substitution - Missense
c.687G>A; p.M229I; 19:50948679-50948679	ovary	other; neoplasm	Substitution - Missense
c.219C>T; p.C73C; 19:50949971-50949971	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.687G>A; p.M229I; 19:50948679-50948679	ovary	other; neoplasm	Substitution - Missense
c.219C>T; p.C73C; 19:50949971-50949971	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.579C>T; p.T193T; 19:50948872-50948872	liver	carcinoma	Substitution - coding silent
c.697G>A; p.G233S; 19:50948669-50948669	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.101C>T; p.S34F; 19:50950089-50950089	skin	malignant_melanoma	Substitution - Missense
c.798T>C; p.C266C; 19:50943715-50943715	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.314C>T; p.T105M; 19:50949876-50949876	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.314C>T; p.T105M; 19:50949876-50949876	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.604A>G; p.K202E; 19:50948762-50948762	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.181G>A; p.D61N; 19:50950009-50950009	NS	malignant_melanoma	Substitution - Missense
c.604A>G; p.K202E; 19:50948762-50948762	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.500A>T; p.K167I; 19:50948951-50948951	skin	malignant_melanoma	Substitution - Missense
c.431G>T; p.G144V; 19:50949020-50949020	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.664C>T; p.P222S; 19:50948702-50948702	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.664C>T; p.P222S; 19:50948702-50948702	skin	malignant_melanoma	Substitution - Missense
c.239G>T; p.W80L; 19:50949951-50949951	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.519C>T; p.N173N; 19:50948932-50948932	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.657T>C; p.D219D; 19:50948709-50948709	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.651C>G; p.C217W; 19:50948715-50948715	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.21C>A; p.P7P; 19:50952637-50952637	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.354C>T; p.L118L; 19:50949097-50949097	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.443C>A; p.P148H; 19:50949008-50949008	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.537C>T; p.P179P; 19:50948914-50948914	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.319G>A; p.A107T; 19:50949871-50949871	urinary_tract; bladder	carcinoma	Substitution - Missense
c.542C>T; p.A181V; 19:50948909-50948909	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.468C>A; p.L156L; 19:50948983-50948983	oesophagus	carcinoma	Substitution - coding silent
c.827C>T; p.T276M; 19:50943686-50943686	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.540T>C; p.S180S; 19:50948911-50948911	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.615G>T; p.Q205H; 19:50948751-50948751	breast	carcinoma	Substitution - Missense
c.120C>A; p.N40K; 19:50950070-50950070	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.191G>A; p.S64N; 19:50949999-50949999	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.769G>A; p.G257R; 19:50943744-50943744	skin	malignant_melanoma	Substitution - Missense
c.435C>A; p.Y145*; 19:50949016-50949016	autonomic_ganglia	neuroblastoma	Substitution - Nonsense
c.613C>T; p.Q205*; 19:50948753-50948753	skin	malignant_melanoma	Substitution - Nonsense
c.595C>T; p.H199Y; 19:50948771-50948771	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.128C>A; p.P43H; 19:50950062-50950062	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.163G>A; p.G55R; 19:50950027-50950027	breast	carcinoma	Substitution - Missense
c.48C>G; p.I16M; 19:50952610-50952610	breast	carcinoma	Substitution - Missense
c.677A>C; p.D226A; 19:50948689-50948689	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.350G>A; p.R117H; 19:50949101-50949101	urinary_tract; bladder	carcinoma	Substitution - Missense
c.610C>A; p.L204I; 19:50948756-50948756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.74A>T; p.E25V; 19:50950116-50950116	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.627C>T; p.I209I; 19:50948739-50948739	skin	malignant_melanoma	Substitution - coding silent
c.582G>A; p.K194K; 19:50948869-50948869	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.491G>A; p.R164H; 19:50948960-50948960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.516C>T; p.I172I; 19:50948935-50948935	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.572G>A; p.G191E; 19:50948879-50948879	skin	malignant_melanoma	Substitution - Missense
c.209G>A; p.G70E; 19:50949981-50949981	skin	malignant_melanoma	Substitution - Missense
c.734C>T; p.S245F; 19:50943779-50943779	skin	malignant_melanoma	Substitution - Missense
c.666G>C; p.P222P; 19:50948700-50948700	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.136A>T; p.S46C; 19:50950054-50950054	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.386C>G; p.S129C; 19:50949065-50949065	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.123C>T; p.T41T; 19:50950067-50950067	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.368T>A; p.L123Q; 19:50949083-50949083	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.450C>T; p.H150H; 19:50949001-50949001	breast	carcinoma	Substitution - coding silent
c.441_442CC>AG; p.H147_P148>QA; 19:50949009-50949010	lung; right_upper_lobe	carcinoma; adenocarcinoma	Complex - compound substitution
c.212C>T; p.S71F; 19:50949978-50949978	skin	malignant_melanoma	Substitution - Missense
c.352C>T; p.L118F; 19:50949099-50949099	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.169G>A; p.D57N; 19:50950021-50950021	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation