lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	25792
Symbol	CIZ1
Synonymous	LSFR1\|NP94\|ZNF356
Full name	CDKN1A interacting zinc finger protein 1
Gene description	cip1-interacting zinc finger protein\|nuclear protein NP94\|zinc finger protein 356
Cytoband	9q34.1
Gene type	protein-coding
Synonymous	MIM:611420; HGNC:HGNC:16744; Ensembl:ENSG00000148337; HPRD:13061; Vega:OTTHUMG00000020735

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.2268C>T; p.I756I; 9:128169079-128169079	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.565T>C; p.S189P; 9:128185570-128185570	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2220C>A; p.F740L; 9:128169127-128169127	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2012G>A; p.R671H; 9:128170039-128170039	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2012G>A; p.R671H; 9:128170039-128170039	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.216G>A; p.Q72Q; 9:128190399-128190399	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.695C>T; p.P232L; 9:128180511-128180511	pancreas	carcinoma	Substitution - Missense
c.1961G>A; p.R654H; 9:128170090-128170090	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2131G>A; p.D711N; 9:128169420-128169420	skin	malignant_melanoma	Substitution - Missense
c.2074C>T; p.R692C; 9:128169477-128169477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2421C>A; p.F807L; 9:128166825-128166825	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.929G>A; p.R310Q; 9:128179278-128179278	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2107C>T; p.H703Y; 9:128169444-128169444	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1407G>T; p.P469P; 9:128178800-128178800	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1512C>A; p.T504T; 9:128178477-128178477	liver	carcinoma	Substitution - coding silent
c.664C>T; p.R222W; 9:128180739-128180739	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.664C>T; p.R222W; 9:128180739-128180739	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1912G>A; p.V638M; 9:128176382-128176382	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.200C>T; p.P67L; 9:128190415-128190415	prostate	carcinoma	Substitution - Missense
c.2218T>C; p.F740L; 9:128169129-128169129	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1411G>A; p.V471M; 9:128178796-128178796	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1497A>G; p.G499G; 9:128178710-128178710	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.832C>T; p.Q278*; 9:128179375-128179375	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1078C>T; p.Q360*; 9:128179129-128179129	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1078C>T; p.Q360*; 9:128179129-128179129	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.535C>T; p.R179W; 9:128185600-128185600	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2337G>A; p.S779S; 9:128167123-128167123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1412T>C; p.V471A; 9:128178795-128178795	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1412T>C; p.V471A; 9:128178795-128178795	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1412T>C; p.V471A; 9:128178795-128178795	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1906_1920del15; p.L636_R640delLPVPR; 9:128176374-128176388	breast	carcinoma	Deletion - In frame
c.1910C>T; p.P637L; 9:128176384-128176384	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1007A>T; p.Q336L; 9:128179200-128179200	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2500G>T; p.A834S; 9:128166394-128166394	breast	carcinoma	Substitution - Missense
c.1270C>T; p.Q424*; 9:128178937-128178937	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1516C>T; p.P506S; 9:128178473-128178473	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1924G>A; p.V642I; 9:128176370-128176370	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.A239T; 9:128180491-128180491	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.497G>T; p.G166V; 9:128185638-128185638	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2617C>T; p.Q873*; 9:128166277-128166277	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1338G>T; p.Q446H; 9:128178869-128178869	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2219T>G; p.F740C; 9:128169128-128169128	liver	carcinoma	Substitution - Missense
c.1133A>G; p.Q378R; 9:128179074-128179074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1911_1923del13; p.V638fs*26; 9:128176371-128176383	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.589G>A; p.D197N; 9:128180814-128180814	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.557G>A; p.R186Q; 9:128185578-128185578	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1586G>C; p.G529A; 9:128178403-128178403	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1498+3A>T; p.?; 9:128178706-128178706	pancreas	carcinoma	Unknown
c.943G>A; p.V315I; 9:128179264-128179264	skin	malignant_melanoma	Substitution - Missense
c.639G>T; p.E213D; 9:128180764-128180764	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2275G>A; p.E759K; 9:128169072-128169072	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2053C>T; p.P685S; 9:128169498-128169498	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.685C>T; p.Q229*; 9:128180521-128180521	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.277C>A; p.Q93K; 9:128190338-128190338	oesophagus	carcinoma	Substitution - Missense
c.235C>T; p.L79F; 9:128190380-128190380	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1918C>T; p.R640W; 9:128176376-128176376	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2220C>T; p.F740F; 9:128169127-128169127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2220C>T; p.F740F; 9:128169127-128169127	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.233C>T; p.S78F; 9:128190382-128190382	skin	malignant_melanoma	Substitution - Missense
c.635C>T; p.P212L; 9:128180768-128180768	skin	malignant_melanoma	Substitution - Missense
c.1818+2T>G; p.?; 9:128177564-128177564	large_intestine; colon	adenoma	Unknown
c.1916C>T; p.P639L; 9:128176378-128176378	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.740C>G; p.P247R; 9:128180466-128180466	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1560T>G; p.N520K; 9:128178429-128178429	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2513G>T; p.S838I; 9:128166381-128166381	thyroid	other; neoplasm	Substitution - Missense
c.941G>C; p.R314P; 9:128179266-128179266	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.859A>T; p.M287L; 9:128179348-128179348	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1594G>C; p.E532Q; 9:128178395-128178395	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.455C>T; p.P152L; 9:128185680-128185680	skin	malignant_melanoma	Substitution - Missense
c.455C>T; p.P152L; 9:128185680-128185680	skin	malignant_melanoma	Substitution - Missense
c.985C>T; p.R329W; 9:128179222-128179222	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2626delA; p.T876fs*5; 9:128166268-128166268	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.35_36insGTT; p.Q12_Q13insL; 9:128190822-128190823	breast	carcinoma	Insertion - In frame
c.1223A>G; p.Q408R; 9:128178984-128178984	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.478C>T; p.L160L; 9:128185657-128185657	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2544C>T; p.C848C; 9:128166350-128166350	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.733C>T; p.P245S; 9:128180473-128180473	skin	malignant_melanoma	Substitution - Missense
c.1913T>C; p.V638A; 9:128176381-128176381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1913T>C; p.V638A; 9:128176381-128176381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2642C>T; p.T881M; 9:128166252-128166252	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1031A>G; p.Q344R; 9:128179176-128179176	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1307A>T; p.H436L; 9:128178900-128178900	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2476G>C; p.E826Q; 9:128166770-128166770	NS	NS	Substitution - Missense
c.1028A>G; p.K343R; 9:128179179-128179179	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1458C>T; p.C486C; 9:128178749-128178749	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1413G>A; p.V471V; 9:128178794-128178794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1413G>A; p.V471V; 9:128178794-128178794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1605G>A; p.A535A; 9:128178384-128178384	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.517C>T; p.Q173*; 9:128185618-128185618	liver	carcinoma	Substitution - Nonsense
c.649G>A; p.E217K; 9:128180754-128180754	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1330C>T; p.Q444*; 9:128178877-128178877	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Nonsense
c.517C>T; p.Q173*; 9:128185618-128185618	liver	carcinoma	Substitution - Nonsense
c.2050C>T; p.R684*; 9:128169501-128169501	breast	carcinoma	Substitution - Nonsense
c.1712G>A; p.R571H; 9:128177672-128177672	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2050C>T; p.R684*; 9:128169501-128169501	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2050C>T; p.R684*; 9:128169501-128169501	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1712G>A; p.R571H; 9:128177672-128177672	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2050C>T; p.R684*; 9:128169501-128169501	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.556C>T; p.R186W; 9:128185579-128185579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.855C>T; p.A285A; 9:128179352-128179352	skin	malignant_melanoma	Substitution - coding silent
c.567_569delCTC; p.S190delS; 9:128185566-128185568	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.217G>A; p.G73S; 9:128190398-128190398	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2404C>T; p.R802C; 9:128166842-128166842	central_nervous_system; brain	glioma; astrocytoma_Grade_III	Substitution - Missense
c.2664A>C; p.P888P; 9:128166230-128166230	ovary	other; neoplasm	Substitution - coding silent
c.401C>T; p.A134V; 9:128185734-128185734	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.176T>C; p.L59P; 9:128190439-128190439	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.530C>T; p.S177L; 9:128185605-128185605	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.176T>C; p.L59P; 9:128190439-128190439	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.765C>T; p.S255S; 9:128180441-128180441	prostate	carcinoma	Substitution - coding silent
c.2653T>C; p.S885P; 9:128166241-128166241	breast	carcinoma	Substitution - Missense
c.176T>C; p.L59P; 9:128190439-128190439	central_nervous_system; brain	glioma	Substitution - Missense
c.1386T>C; p.H462H; 9:128178821-128178821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2510C>T; p.P837L; 9:128166384-128166384	thyroid	other; neoplasm	Substitution - Missense
c.1292C>G; p.T431R; 9:128178915-128178915	ovary	other; neoplasm	Substitution - Missense
c.2065G>A; p.V689I; 9:128169486-128169486	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1726G>A; p.V576I; 9:128177658-128177658	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832	liver	carcinoma	Deletion - In frame
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - In frame
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832	skin; extremity	malignant_melanoma	Deletion - In frame
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832	skin; back	malignant_melanoma	Deletion - In frame
c.2592C>T; p.G864G; 9:128166302-128166302	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1361C>T; p.S454L; 9:128178846-128178846	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.2253G>T; p.E751D; 9:128169094-128169094	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1629C>T; p.G543G; 9:128177755-128177755	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.279G>C; p.Q93H; 9:128190336-128190336	skin	malignant_melanoma	Substitution - Missense
c.955C>T; p.Q319*; 9:128179252-128179252	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.473C>T; p.S158F; 9:128185662-128185662	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation