lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2547
Symbol	XRCC6
Synonymous	CTC75\|CTCBF\|G22P1\|KU70\|ML8\|TLAA
Full name	X-ray repair complementing defective repair in Chinese hamster cells 6
Gene description	5'-dRP lyase Ku70\|5'-deoxyribose-5-phosphate lyase Ku70\|70 kDa subunit of Ku antigen\|ATP-dependent DNA helicase 2 subunit 1\|ATP-dependent DNA helicase II 70 kDa subunit\|ATP-dependent DNA helicase II, 70 kDa subunit\|CTC box binding factor 75 kDa subunit\|CT
Cytoband	22q13.2
Gene type	protein-coding
Synonymous	MIM:152690; HGNC:HGNC:4055; Ensembl:ENSG00000196419; HPRD:01071; Vega:OTTHUMG00000151190

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.287C>T; p.S96L; 22:41636204-41636204	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.589+1G>T; p.?; 22:41636771-41636771	lung	carcinoma; adenocarcinoma	Unknown
c.466G>A; p.D156N; 22:41636647-41636647	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.667A>G; p.I223V; 22:41637685-41637685	liver	carcinoma	Substitution - Missense
c.667A>G; p.I223V; 22:41637685-41637685	liver	carcinoma	Substitution - Missense
c.160G>A; p.E54K; 22:41628195-41628195	breast	carcinoma	Substitution - Missense
c.667A>G; p.I223V; 22:41637685-41637685	liver	carcinoma	Substitution - Missense
c.667A>G; p.I223V; 22:41637685-41637685	liver	carcinoma	Substitution - Missense
c.905C>T; p.T302I; 22:41647027-41647027	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1443C>T; p.P481P; 22:41658273-41658273	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1443C>T; p.P481P; 22:41658273-41658273	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1254A>G; p.E418E; 22:41653653-41653653	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1254A>G; p.E418E; 22:41653653-41653653	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.31G>C; p.E11Q; 22:41622035-41622035	breast	carcinoma	Substitution - Missense
c.1255G>A; p.E419K; 22:41653654-41653654	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1637-1G>T; p.?; 22:41663621-41663621	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.589G>C; p.G197R; 22:41636770-41636770	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.781C>T; p.L261L; 22:41646903-41646903	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1159A>C; p.I387L; 22:41653558-41653558	lung	carcinoma; undifferentiated_carcinoma	Substitution - Missense
c.60A>G; p.Q20Q; 22:41622064-41622064	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1118C>T; p.S373L; 22:41650880-41650880	skin	malignant_melanoma	Substitution - Missense
c.280A>G; p.K94E; 22:41636197-41636197	skin	malignant_melanoma	Substitution - Missense
c.590-2A>C; p.?; 22:41637606-41637606	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1493T>G; p.M498R; 22:41658323-41658323	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.91A>G; p.K31E; 22:41628126-41628126	liver	carcinoma	Substitution - Missense
c.1177G>T; p.E393*; 22:41653576-41653576	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1591C>T; p.P531S; 22:41661399-41661399	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.452C>T; p.A151V; 22:41636633-41636633	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1292-1G>T; p.?; 22:41656902-41656902	stomach	carcinoma; adenocarcinoma	Unknown
c.1703T>C; p.I568T; 22:41663688-41663688	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1715C>T; p.T572M; 22:41663700-41663700	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.535G>C; p.D179H; 22:41636716-41636716	breast	carcinoma	Substitution - Missense
c.1797G>A; p.L599L; 22:41663782-41663782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1330A>G; p.R444G; 22:41656941-41656941	thyroid	carcinoma	Substitution - Missense
c.1795C>A; p.L599M; 22:41663780-41663780	pancreas	carcinoma	Substitution - Missense
c.973C>T; p.R325C; 22:41650735-41650735	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.193C>A; p.Q65K; 22:41628228-41628228	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.799A>G; p.I267V; 22:41646921-41646921	liver	carcinoma	Substitution - Missense
c.343C>T; p.R115*; 22:41636524-41636524	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.1359_1378del20; p.A454fs*7; 22:41656970-41656989	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1359_1378del20; p.A454fs*7; 22:41656970-41656989	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.347T>G; p.I116S; 22:41636528-41636528	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1636+1G>A; p.?; 22:41661445-41661445	skin	malignant_melanoma	Unknown
c.1636+1G>A; p.?; 22:41661445-41661445	skin	malignant_melanoma	Unknown
c.838G>T; p.A280S; 22:41646960-41646960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1055C>T; p.P352L; 22:41650817-41650817	ovary	other; neoplasm	Substitution - Missense
c.641C>T; p.S214F; 22:41637659-41637659	urinary_tract; bladder	carcinoma	Substitution - Missense
c.83G>A; p.G28E; 22:41628118-41628118	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.960+10G>A; p.?; 22:41647092-41647092	pancreas	carcinoma; adenocarcinoma	Unknown
c.1636+1G>A; p.?; 22:41661445-41661445	skin	malignant_melanoma	Unknown
c.1636+1G>A; p.?; 22:41661445-41661445	skin	malignant_melanoma	Unknown
c.1635C>T; p.H545H; 22:41661443-41661443	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1279G>A; p.V427M; 22:41653678-41653678	eye; uveal_tract	malignant_melanoma; spindle	Substitution - Missense
c.1637-6C>T; p.?; 22:41663616-41663616	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1660A>T; p.R554W; 22:41663645-41663645	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.670G>A; p.A224T; 22:41637688-41637688	oesophagus	carcinoma	Substitution - Missense
c.2T>C; p.M1T; 22:41622006-41622006	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.642C>T; p.S214S; 22:41637660-41637660	skin	malignant_melanoma	Substitution - coding silent
c.717A>T; p.L239L; 22:41637735-41637735	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1084C>A; p.L362M; 22:41650846-41650846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1254A>C; p.E418D; 22:41653653-41653653	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1223C>T; p.P408L; 22:41653622-41653622	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1409G>A; p.R470H; 22:41657020-41657020	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1499C>T; p.P500L; 22:41658329-41658329	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.457C>T; p.L153F; 22:41636638-41636638	skin	malignant_melanoma	Substitution - Missense
c.1288C>G; p.P430A; 22:41653687-41653687	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1297C>T; p.Q433*; 22:41656908-41656908	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.796G>T; p.D266Y; 22:41646918-41646918	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.500T>A; p.M167K; 22:41636681-41636681	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.500T>A; p.M167K; 22:41636681-41636681	stomach	adenocarcinoma	Substitution - Missense
c.993A>C; p.K331N; 22:41650755-41650755	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.993A>C; p.K331N; 22:41650755-41650755	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.492G>C; p.K164N; 22:41636673-41636673	breast	carcinoma	Substitution - Missense
c.1060G>C; p.V354L; 22:41650822-41650822	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.283A>C; p.N95H; 22:41636200-41636200	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1016G>A; p.R339Q; 22:41650778-41650778	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1312C>T; p.P438S; 22:41656923-41656923	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.772A>T; p.R258W; 22:41637790-41637790	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1101C>T; p.F367F; 22:41650863-41650863	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.594C>T; p.I198I; 22:41637612-41637612	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.144G>A; p.M48I; 22:41628179-41628179	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.583G>C; p.D195H; 22:41636764-41636764	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.289G>A; p.V97M; 22:41636206-41636206	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1779G>T; p.G593G; 22:41663764-41663764	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1779G>T; p.G593G; 22:41663764-41663764	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.707C>T; p.S236F; 22:41637725-41637725	skin	malignant_melanoma	Substitution - Missense
c.1383G>A; p.K461K; 22:41656994-41656994	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1296C>T; p.F432F; 22:41656907-41656907	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1020T>A; p.F340L; 22:41650782-41650782	skin	malignant_melanoma	Substitution - Missense
c.342A>G; p.K114K; 22:41636523-41636523	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.982A>G; p.I328V; 22:41650744-41650744	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.947C>T; p.T316I; 22:41647069-41647069	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1435G>C; p.E479Q; 22:41658265-41658265	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.783G>A; p.L261L; 22:41646905-41646905	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.800T>C; p.I267T; 22:41646922-41646922	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.583G>T; p.D195Y; 22:41636764-41636764	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.846G>T; p.K282N; 22:41646968-41646968	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.142A>G; p.M48V; 22:41628177-41628177	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1253A>G; p.E418G; 22:41653652-41653652	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1253A>G; p.E418G; 22:41653652-41653652	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.855A>C; p.P285P; 22:41646977-41646977	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1444G>A; p.V482M; 22:41658274-41658274	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.850C>T; p.P284S; 22:41646972-41646972	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1242G>A; p.V414V; 22:41653641-41653641	breast	carcinoma	Substitution - coding silent
c.809C>G; p.S270C; 22:41646931-41646931	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1525C>T; p.P509S; 22:41661333-41661333	prostate	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation