lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2524
Symbol	FUT2
Synonymous	B12QTL1\|SE\|SEC2\|Se2\|sej
Full name	fucosyltransferase 2 (secretor status included)
Gene description	GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2\|alpha (1,2) fucosyltransferase\|alpha(1,2)FT 2\|alpha(1,2)FT2\|galactoside 2-alpha-L-fucosyltransferase 2\|secretor blood group alpha-2-fucosyltransferase\|secretor factor
Cytoband	19q13.3
Gene type	protein-coding
Synonymous	MIM:182100; HGNC:HGNC:4013; Ensembl:ENSG00000176920; HPRD:01629; Vega:OTTHUMG00000164427

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.772G>A; p.G258S; 19:48703728-48703728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.478C>A; p.L160I; 19:48703434-48703434	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.662G>T; p.R221L; 19:48703618-48703618	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.870G>A; p.T290T; 19:48703826-48703826	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.249C>T; p.Y83Y; 19:48703205-48703205	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.249C>T; p.Y83Y; 19:48703205-48703205	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.64G>A; p.V22I; 19:48703020-48703020	skin	malignant_melanoma	Substitution - Missense
c.418A>T; p.I140F; 19:48703374-48703374	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.577G>A; p.G193S; 19:48703533-48703533	skin	malignant_melanoma	Substitution - Missense
c.279C>T; p.A93A; 19:48703235-48703235	skin	malignant_melanoma	Substitution - coding silent
c.62C>T; p.T21M; 19:48703018-48703018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.444C>G; p.T148T; 19:48703400-48703400	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.194C>T; p.T65M; 19:48703150-48703150	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.423G>A; p.P141P; 19:48703379-48703379	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.525G>C; p.R175R; 19:48703481-48703481	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.896C>T; p.T299M; 19:48703852-48703852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.597T>C; p.H199H; 19:48703553-48703553	breast	carcinoma	Substitution - coding silent
c.270G>A; p.G90G; 19:48703226-48703226	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.981G>T; p.L327L; 19:48703937-48703937	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2T>C; p.M1T; 19:48702958-48702958	liver	carcinoma	Substitution - Missense
c.2T>C; p.M1T; 19:48702958-48702958	liver	carcinoma	Substitution - Missense
c.749G>A; p.R250Q; 19:48703705-48703705	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.89A>T; p.Q30L; 19:48703045-48703045	skin	malignant_melanoma	Substitution - Missense
c.658C>T; p.R220W; 19:48703614-48703614	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.894C>T; p.L298L; 19:48703850-48703850	liver	carcinoma	Substitution - coding silent
c.985G>C; p.E329Q; 19:48703941-48703941	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.894C>T; p.L298L; 19:48703850-48703850	liver	carcinoma	Substitution - coding silent
c.409delT; p.Y137fs*51; 19:48703365-48703365	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.288G>A; p.P96P; 19:48703244-48703244	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.433G>A; p.V145I; 19:48703389-48703389	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.461G>A; p.W154*; 19:48703417-48703417	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.461G>A; p.W154*; 19:48703417-48703417	breast	carcinoma	Substitution - Nonsense
c.461G>A; p.W154*; 19:48703417-48703417	breast	carcinoma	Substitution - Nonsense
c.243A>G; p.T81T; 19:48703199-48703199	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.461G>A; p.W154*; 19:48703417-48703417	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.461G>A; p.W154*; 19:48703417-48703417	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.46A>T; p.I16F; 19:48703002-48703002	thyroid	other; neoplasm	Substitution - Missense
c.660G>A; p.R220R; 19:48703616-48703616	breast	carcinoma	Substitution - coding silent
c.523C>T; p.R175W; 19:48703479-48703479	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.423delG; p.E143fs*45; 19:48703379-48703379	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.167G>A; p.G56E; 19:48703123-48703123	skin	malignant_melanoma	Substitution - Missense
c.575C>T; p.P192L; 19:48703531-48703531	liver	carcinoma	Substitution - Missense
c.61A>C; p.T21P; 19:48703017-48703017	skin	malignant_melanoma	Substitution - Missense
c.231C>T; p.G77G; 19:48703187-48703187	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.10G>A; p.V4I; 19:48702966-48702966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.238G>A; p.A80T; 19:48703194-48703194	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.654C>T; p.A218A; 19:48703610-48703610	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.203C>T; p.A68V; 19:48703159-48703159	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.40C>A; p.H14N; 19:48702996-48702996	urinary_tract; bladder	carcinoma	Substitution - Missense
c.363G>A; p.R121R; 19:48703319-48703319	skin	malignant_melanoma	Substitution - coding silent
c.182G>A; p.R61K; 19:48703138-48703138	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.531G>A; p.E177E; 19:48703487-48703487	skin	malignant_melanoma	Substitution - coding silent
c.349G>A; p.A117T; 19:48703305-48703305	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.344A>C; p.H115P; 19:48703300-48703300	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.342G>A; p.L114L; 19:48703298-48703298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.570C>T; p.S190S; 19:48703526-48703526	skin	malignant_melanoma	Substitution - coding silent
c.570C>T; p.S190S; 19:48703526-48703526	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.873C>T; p.F291F; 19:48703829-48703829	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.239C>A; p.A80D; 19:48703195-48703195	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.993A>G; p.T331T; 19:48703949-48703949	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.413G>C; p.R138P; 19:48703369-48703369	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.916C>T; p.L306L; 19:48703872-48703872	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.642delG; p.V216fs*71; 19:48703598-48703598	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.353C>T; p.T118M; 19:48703309-48703309	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.204A>G; p.A68A; 19:48703160-48703160	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.175C>T; p.Q59*; 19:48703131-48703131	pancreas	carcinoma	Substitution - Nonsense
c.886G>A; p.A296T; 19:48703842-48703842	skin	malignant_melanoma	Substitution - Missense
c.886G>A; p.A296T; 19:48703842-48703842	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.212G>A; p.R71H; 19:48703168-48703168	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1003G>A; p.A335T; 19:48703959-48703959	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.948C>T; p.F316F; 19:48703904-48703904	skin	malignant_melanoma	Substitution - coding silent
c.661C>T; p.R221*; 19:48703617-48703617	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.390C>T; p.N130N; 19:48703346-48703346	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.425G>A; p.G142E; 19:48703381-48703381	skin	malignant_melanoma	Substitution - Missense
c.390C>T; p.N130N; 19:48703346-48703346	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.967G>A; p.E323K; 19:48703923-48703923	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.670C>A; p.Q224K; 19:48703626-48703626	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation