Cancer metastasis database

Annotation category 5

Gene information

Gene ID 2356
Symbol

FPGS

Synonymous

-

Full name

folylpolyglutamate synthase

Gene description

folylpoly-gamma-glutamate synthetase|folylpolyglutamate synthase, mitochondrial|tetrahydrofolate synthase|tetrahydrofolylpolyglutamate synthase

Cytoband

9q34.1

Gene type

protein-coding

Synonymous

MIM:136510; HGNC:HGNC:3824; Ensembl:ENSG00000136877; HPRD:00642; Vega:OTTHUMG00000020716

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.133T>G; p.Y45D; 9:127803057-127803057

 pancreascarcinoid-endocrine_tumourSubstitution - Missense

c.428A>G; p.N143S; 9:127807014-127807014

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Missense

c.428A>G; p.N143S; 9:127807014-127807014

 central_nervous_system; braingliomaSubstitution - Missense

c.228G>T; p.L76F; 9:127804374-127804374

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.416G>A; p.R139Q; 9:127807002-127807002

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.1219G>A; p.E407K; 9:127810038-127810038

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.145G>A; p.V49M; 9:127804291-127804291

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1618C>T; p.P540S; 9:127813458-127813458

 breastcarcinomaSubstitution - Missense

c.842C>T; p.P281L; 9:127808577-127808577

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1328C>A; p.T443K; 9:127810985-127810985

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.567C>T; p.F189F; 9:127807274-127807274

 skinmalignant_melanomaSubstitution - coding silent

c.855C>G; p.A285A; 9:127808590-127808590

 central_nervous_system; braingliomaSubstitution - coding silent

c.311C>T; p.T104M; 9:127804542-127804542

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.259G>T; p.G87W; 9:127804405-127804405

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.311C>T; p.T104M; 9:127804542-127804542

 livercarcinomaSubstitution - Missense

c.311C>T; p.T104M; 9:127804542-127804542

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.204G>A; p.Q68Q; 9:127804350-127804350

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.207G>T; p.R69R; 9:127804353-127804353

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.201C>T; p.R67R; 9:127804347-127804347

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.200G>T; p.R67L; 9:127804346-127804346

 pancreascarcinomaSubstitution - Missense

c.916G>A; p.A306T; 9:127808651-127808651

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.1434C>G; p.D478E; 9:127813274-127813274

 skinmalignant_melanomaSubstitution - Missense

c.1158G>C; p.Q386H; 9:127809781-127809781

 thyroidother; neoplasmSubstitution - Missense

c.210T>G; p.G70G; 9:127804356-127804356

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.876G>A; p.P292P; 9:127808611-127808611

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.297C>T; p.I99I; 9:127804528-127804528

 skinmalignant_melanomaSubstitution - coding silent

c.1529G>A; p.C510Y; 9:127813369-127813369

 breastcarcinomaSubstitution - Missense

c.64A>G; p.I22V; 9:127802988-127802988

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.64A>G; p.I22V; 9:127802988-127802988

 thyroidother; neoplasmSubstitution - Missense

c.64A>G; p.I22V; 9:127802988-127802988

 thyroidother; neoplasmSubstitution - Missense

c.64A>G; p.I22V; 9:127802988-127802988

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - Missense

c.203A>G; p.Q68R; 9:127804349-127804349

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1483G>A; p.G495S; 9:127813323-127813323

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1656T>C; p.S552S; 9:127813496-127813496

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.670C>T; p.L224F; 9:127807614-127807614

 skinmalignant_melanomaSubstitution - Missense

c.487C>A; p.L163M; 9:127807073-127807073

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1393C>T; p.L465F; 9:127813233-127813233

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.882C>T; p.T294T; 9:127808617-127808617

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1552A>G; p.S518G; 9:127813392-127813392

 central_nervous_system; braingliomaSubstitution - Missense

c.1639C>G; p.H547D; 9:127813479-127813479

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1639C>G; p.H547D; 9:127813479-127813479

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.143C>T; p.A48V; 9:127804289-127804289

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1225C>G; p.R409G; 9:127810044-127810044

 pancreascarcinomaSubstitution - Missense

c.1553G>A; p.S518N; 9:127813393-127813393

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.472C>T; p.R158C; 9:127807058-127807058

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.611G>A; p.G204D; 9:127807452-127807452

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.473G>A; p.R158H; 9:127807059-127807059

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1491C>T; p.S497S; 9:127813331-127813331

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.679G>A; p.D227N; 9:127807623-127807623

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.191A>G; p.Q64R; 9:127804337-127804337

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.199C>A; p.R67S; 9:127804345-127804345

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.152T>C; p.M51T; 9:127804298-127804298

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.422G>A; p.R141H; 9:127807008-127807008

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.1425C>G; p.N475K; 9:127813265-127813265

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.206G>A; p.R69Q; 9:127804352-127804352

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.365G>A; p.G122D; 9:127804679-127804679

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.612C>T; p.G204G; 9:127807453-127807453

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.479A>G; p.Y160C; 9:127807065-127807065

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.205C>G; p.R69G; 9:127804351-127804351

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1750G>T; p.A584S; 9:127813590-127813590

 oesophaguscarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1249G>A; p.G417R; 9:127810068-127810068

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1351G>A; p.A451T; 9:127811008-127811008

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.284G>A; p.R95Q; 9:127804515-127804515

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.166C>T; p.Q56*; 9:127804312-127804312

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.544A>G; p.T182A; 9:127807251-127807251

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1517C>A; p.P506Q; 9:127813357-127813357

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1666A>G; p.I556V; 9:127813506-127813506

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1666A>G; p.I556V; 9:127813506-127813506

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.700G>A; p.D234N; 9:127807644-127807644

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.700G>A; p.D234N; 9:127807644-127807644

 skinmalignant_melanomaSubstitution - Missense

c.147G>A; p.V49V; 9:127804293-127804293

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.147G>A; p.V49V; 9:127804293-127804293

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.1553G>T; p.S518I; 9:127813393-127813393

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1671_1672CC>TT; p.R558C; 9:127813511-127813512

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.963C>T; p.D321D; 9:127808698-127808698

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.202C>A; p.Q68K; 9:127804348-127804348

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1688T>G; p.I563S; 9:127813528-127813528

 breastcarcinomaSubstitution - Missense

c.1005C>T; p.L335L; 9:127808834-127808834

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.243G>A; p.L81L; 9:127804389-127804389

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.523C>T; p.P175S; 9:127807230-127807230

 skinmalignant_melanomaSubstitution - Missense

c.321+2T>G; p.?; 9:127804554-127804554

 breastcarcinomaUnknown

c.356G>A; p.R119Q; 9:127804670-127804670

 pancreascarcinomaSubstitution - Missense

c.1591C>T; p.R531*; 9:127813431-127813431

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense