lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	23452
Symbol	ANGPTL2
Synonymous	ARP2\|HARP
Full name	angiopoietin-like 2
Gene description	angiopoietin-like protein 2\|angiopoietin-related protein 2
Cytoband	9q34
Gene type	protein-coding
Synonymous	MIM:605001; HGNC:HGNC:490; Ensembl:ENSG00000136859; HPRD:05415; Vega:OTTHUMG00000020695

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1447A>G; p.M483V; 9:127088974-127088974	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1336T>A; p.S446T; 9:127089085-127089085	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.661C>T; p.P221S; 9:127108071-127108071	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.371G>A; p.R124H; 9:127108361-127108361	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1447A>G; p.M483V; 9:127088974-127088974	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1204G>A; p.G402S; 9:127091748-127091748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.430G>A; p.E144K; 9:127108302-127108302	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1368C>G; p.G456G; 9:127089053-127089053	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.669G>A; p.R223R; 9:127108063-127108063	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.378G>A; p.E126E; 9:127108354-127108354	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.680C>T; p.P227L; 9:127108052-127108052	skin	malignant_melanoma	Substitution - Missense
c.136C>T; p.R46W; 9:127108596-127108596	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1414C>T; p.R472*; 9:127089007-127089007	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1414C>T; p.R472*; 9:127089007-127089007	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1154G>A; p.R385H; 9:127091798-127091798	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1119C>T; p.S373S; 9:127091833-127091833	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.148T>C; p.S50P; 9:127108584-127108584	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1121G>A; p.G374D; 9:127091831-127091831	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1028T>C; p.I343T; 9:127091924-127091924	large_intestine; colon	adenoma	Substitution - Missense
c.1098G>C; p.L366L; 9:127091854-127091854	central_nervous_system; brain	glioma	Substitution - coding silent
c.964C>T; p.R322C; 9:127093780-127093780	pancreas	carcinoma	Substitution - Missense
c.626C>T; p.S209L; 9:127108106-127108106	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1362C>T; p.R454R; 9:127089059-127089059	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.810G>A; p.K270K; 9:127107922-127107922	breast	carcinoma; ductal_carcinoma	Substitution - coding silent
c.355G>A; p.E119K; 9:127108377-127108377	breast	carcinoma	Substitution - Missense
c.816G>C; p.S272S; 9:127107916-127107916	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.453C>T; p.N151N; 9:127108279-127108279	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1238G>A; p.G413D; 9:127091714-127091714	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.767C>G; p.P256R; 9:127107965-127107965	bone; pelvis	chondrosarcoma	Substitution - Missense
c.990C>T; p.F330F; 9:127093754-127093754	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.990C>T; p.F330F; 9:127093754-127093754	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.247C>T; p.R83*; 9:127108485-127108485	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.593C>T; p.A198V; 9:127108139-127108139	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1004C>T; p.T335M; 9:127093740-127093740	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.537G>T; p.L179L; 9:127108195-127108195	breast	carcinoma	Substitution - coding silent
c.672C>T; p.V224V; 9:127108060-127108060	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.720C>T; p.N240N; 9:127108012-127108012	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.576C>A; p.N192K; 9:127108156-127108156	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.595C>T; p.Q199*; 9:127108137-127108137	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.569_570CC>TT; p.A190V; 9:127108162-127108163	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.109G>T; p.E37*; 9:127108623-127108623	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.109G>T; p.E37*; 9:127108623-127108623	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.91G>A; p.E31K; 9:127108641-127108641	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1078C>A; p.Q360K; 9:127091874-127091874	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.987C>T; p.F329F; 9:127093757-127093757	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.863C>T; p.T288I; 9:127093881-127093881	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.81delT; p.F27fs*15; 9:127108651-127108651	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.859G>A; p.D287N; 9:127093885-127093885	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.190C>T; p.R64W; 9:127108542-127108542	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.404C>T; p.T135M; 9:127108328-127108328	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.404C>T; p.T135M; 9:127108328-127108328	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.429C>T; p.H143H; 9:127108303-127108303	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1262G>A; p.R421K; 9:127091690-127091690	skin	malignant_melanoma	Substitution - Missense
c.957C>T; p.I319I; 9:127093787-127093787	bone; humerus	chondrosarcoma	Substitution - coding silent
c.416T>A; p.M139K; 9:127108316-127108316	thyroid	carcinoma	Substitution - Missense
c.975C>A; p.G325G; 9:127093769-127093769	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1235A>G; p.N412S; 9:127091717-127091717	central_nervous_system; brain	glioma	Substitution - Missense
c.354C>T; p.S118S; 9:127108378-127108378	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1392C>T; p.D464D; 9:127089029-127089029	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1392C>T; p.D464D; 9:127089029-127089029	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1236C>T; p.N412N; 9:127091716-127091716	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1264G>T; p.D422Y; 9:127091688-127091688	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.165C>T; p.T55T; 9:127108567-127108567	skin	malignant_melanoma	Substitution - coding silent
c.15C>T; p.C5C; 9:127108717-127108717	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.383G>C; p.R128P; 9:127108349-127108349	liver	carcinoma	Substitution - Missense
c.383G>C; p.R128P; 9:127108349-127108349	liver	carcinoma	Substitution - Missense
c.383G>A; p.R128H; 9:127108349-127108349	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.383G>A; p.R128H; 9:127108349-127108349	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.383G>A; p.R128H; 9:127108349-127108349	large_intestine; colon	carcinoma	Substitution - Missense
c.383G>A; p.R128H; 9:127108349-127108349	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.455C>T; p.A152V; 9:127108277-127108277	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.97G>A; p.G33S; 9:127108635-127108635	skin	malignant_melanoma	Substitution - Missense
c.965G>A; p.R322H; 9:127093779-127093779	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1073C>T; p.T358M; 9:127091879-127091879	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1434C>G; p.L478L; 9:127088987-127088987	breast	carcinoma	Substitution - coding silent
c.674_675insGGA; p.Y225>*; 9:127108057-127108058	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1230G>A; p.W410*; 9:127091722-127091722	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.405G>A; p.T135T; 9:127108327-127108327	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1195C>G; p.R399G; 9:127091757-127091757	breast	carcinoma	Substitution - Missense
c.671T>G; p.V224G; 9:127108061-127108061	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.648A>C; p.P216P; 9:127108084-127108084	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1351_1352insG; p.V451fs*20; 9:127089069-127089070	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Insertion - Frameshift
c.382C>T; p.R128C; 9:127108350-127108350	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.695G>A; p.R232H; 9:127108037-127108037	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.695G>A; p.R232H; 9:127108037-127108037	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.646C>T; p.P216S; 9:127108086-127108086	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.101C>T; p.S34L; 9:127108631-127108631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1347C>T; p.N449N; 9:127089074-127089074	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1347C>T; p.N449N; 9:127089074-127089074	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.888G>C; p.P296P; 9:127093856-127093856	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.8C>G; p.P3R; 9:127108724-127108724	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1032C>T; p.D344D; 9:127091920-127091920	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1032C>T; p.D344D; 9:127091920-127091920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1032C>T; p.D344D; 9:127091920-127091920	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1413C>T; p.F471F; 9:127089008-127089008	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation