lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	23221
Symbol	RHOBTB2
Synonymous	DBC2
Full name	Rho-related BTB domain containing 2
Gene description	deleted in breast cancer 2 gene protein\|p83\|rho-related BTB domain-containing protein 2
Cytoband	8p21.3
Gene type	protein-coding
Synonymous	MIM:607352; HGNC:HGNC:18756; Ensembl:ENSG00000008853; HPRD:06300; Vega:OTTHUMG00000097827

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.464C>T; p.A155V; 8:23006127-23006127	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.802G>A; p.V268I; 8:23007047-23007047	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.970G>T; p.D324Y; 8:23007215-23007215	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1125A>C; p.G375G; 8:23007370-23007370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.568G>T; p.V190L; 8:23006813-23006813	bone; pelvis	chondrosarcoma	Substitution - Missense
c.537G>A; p.K179K; 8:23006782-23006782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.186C>T; p.C62C; 8:23004620-23004620	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1789G>T; p.G597W; 8:23014707-23014707	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.723G>A; p.P241P; 8:23006968-23006968	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.606C>T; p.N202N; 8:23006851-23006851	pancreas	carcinoma	Substitution - coding silent
c.820G>A; p.E274K; 8:23007065-23007065	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1039G>A; p.V347M; 8:23007284-23007284	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.606C>T; p.N202N; 8:23006851-23006851	pancreas	carcinoma	Substitution - coding silent
c.34G>A; p.V12I; 8:23004468-23004468	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.368A>C; p.Y123S; 8:23006031-23006031	breast	carcinoma	Substitution - Missense
c.1594C>G; p.P532A; 8:23008085-23008085	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.899T>C; p.L300P; 8:23007144-23007144	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.209G>T; p.R70L; 8:23005388-23005388	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.830G>A; p.R277H; 8:23007075-23007075	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.830G>A; p.R277H; 8:23007075-23007075	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1381C>T; p.R461C; 8:23007626-23007626	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1692C>T; p.T564T; 8:23010609-23010609	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.434G>A; p.R145H; 8:23006097-23006097	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1536C>T; p.S512S; 8:23008027-23008027	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.278G>A; p.R93H; 8:23005457-23005457	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.397G>T; p.A133S; 8:23006060-23006060	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.668A>G; p.N223S; 8:23006913-23006913	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.69C>T; p.N23N; 8:23004503-23004503	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.523C>T; p.R175W; 8:23006768-23006768	skin	malignant_melanoma	Substitution - Missense
c.276C>T; p.D92D; 8:23005455-23005455	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.832A>G; p.I278V; 8:23007077-23007077	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.277C>T; p.R93C; 8:23005456-23005456	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.918G>T; p.G306G; 8:23007163-23007163	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.610A>G; p.I204V; 8:23006855-23006855	breast	carcinoma	Substitution - Missense
c.1659C>T; p.A553A; 8:23010576-23010576	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.71C>T; p.A24V; 8:23004505-23004505	skin	malignant_melanoma	Substitution - Missense
c.71C>T; p.A24V; 8:23004505-23004505	skin	malignant_melanoma	Substitution - Missense
c.71C>T; p.A24V; 8:23004505-23004505	skin	malignant_melanoma	Substitution - Missense
c.1413G>T; p.E471D; 8:23007658-23007658	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1559C>T; p.S520F; 8:23008050-23008050	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1559C>T; p.S520F; 8:23008050-23008050	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2098C>T; p.R700C; 8:23017383-23017383	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2053C>T; p.R685C; 8:23017338-23017338	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1050C>T; p.S350S; 8:23007295-23007295	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.838_839insC; p.H281fs*14; 8:23007083-23007084	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.845A>C; p.K282T; 8:23007090-23007090	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.470G>T; p.R157L; 8:23006133-23006133	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.325A>G; p.I109V; 8:23005988-23005988	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1993C>T; p.R665W; 8:23017278-23017278	prostate	carcinoma	Substitution - Missense
c.1886A>G; p.D629G; 8:23015663-23015663	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.232G>A; p.V78I; 8:23005411-23005411	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.594C>T; p.D198D; 8:23006839-23006839	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1966G>A; p.E656K; 8:23015743-23015743	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1068C>T; p.G356G; 8:23007313-23007313	skin	malignant_melanoma	Substitution - coding silent
c.582C>T; p.F194F; 8:23006827-23006827	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.209G>A; p.R70Q; 8:23005388-23005388	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.15G>A; p.M5I; 8:23004449-23004449	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.169G>A; p.D57N; 8:23004603-23004603	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.169G>A; p.D57N; 8:23004603-23004603	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.876C>A; p.F292L; 8:23007121-23007121	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.392C>G; p.P131R; 8:23006055-23006055	prostate	adenoma	Substitution - Missense
c.1072G>T; p.G358C; 8:23007317-23007317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.393C>A; p.P131P; 8:23006056-23006056	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1616G>A; p.R539Q; 8:23008107-23008107	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1616G>A; p.R539Q; 8:23008107-23008107	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.996C>T; p.H332H; 8:23007241-23007241	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.532G>A; p.A178T; 8:23006777-23006777	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1007G>A; p.R336Q; 8:23007252-23007252	skin	malignant_melanoma	Substitution - Missense
c.1184G>A; p.S395N; 8:23007429-23007429	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.717G>A; p.P239P; 8:23006962-23006962	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1304C>T; p.T435M; 8:23007549-23007549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1410T>C; p.N470N; 8:23007655-23007655	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1975_1977delGAG; p.E659delE; 8:23017260-23017262	ovary	carcinoma; adenocarcinoma	Deletion - In frame
c.982C>T; p.H328Y; 8:23007227-23007227	breast	carcinoma	Substitution - Missense
c.52G>A; p.V18I; 8:23004486-23004486	oesophagus	carcinoma	Substitution - Missense
c.267C>G; p.H89Q; 8:23005446-23005446	central_nervous_system; brain	glioma; oligoastrocytoma	Substitution - Missense
c.1054G>A; p.D352N; 8:23007299-23007299	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.567C>T; p.S189S; 8:23006812-23006812	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1450G>A; p.V484I; 8:23007695-23007695	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1640G>A; p.S547N; 8:23010557-23010557	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.117C>T; p.T39T; 8:23004551-23004551	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.849C>T; p.I283I; 8:23007094-23007094	skin	malignant_melanoma	Substitution - coding silent
c.1305delG; p.E437fs*2; 8:23007550-23007550	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.849C>T; p.I283I; 8:23007094-23007094	skin	malignant_melanoma	Substitution - coding silent
c.217G>A; p.V73I; 8:23005396-23005396	pancreas	carcinoma	Substitution - Missense
c.1780A>G; p.T594A; 8:23014698-23014698	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.486C>T; p.P162P; 8:23006731-23006731	skin	malignant_melanoma	Substitution - coding silent
c.433C>T; p.R145C; 8:23006096-23006096	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.93C>A; p.I31I; 8:23004527-23004527	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1466G>A; p.R489Q; 8:23007711-23007711	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1045G>A; p.E349K; 8:23007290-23007290	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1045G>A; p.E349K; 8:23007290-23007290	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1620+5G>T; p.?; 8:23008116-23008116	skin	malignant_melanoma	Unknown
c.1749G>A; p.L583L; 8:23010666-23010666	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1097C>T; p.T366I; 8:23007342-23007342	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1962C>A; p.S654S; 8:23015739-23015739	kidney	other; neoplasm	Substitution - coding silent
c.915delG; p.G307fs*88; 8:23007160-23007160	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1534A>G; p.S512G; 8:23008025-23008025	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1154T>C; p.V385A; 8:23007399-23007399	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1139C>T; p.P380L; 8:23007384-23007384	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1114C>T; p.R372W; 8:23007359-23007359	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1375G>C; p.D459H; 8:23007620-23007620	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1114C>T; p.R372W; 8:23007359-23007359	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.214G>A; p.V72M; 8:23005393-23005393	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.703delC; p.K237fs*64; 8:23006948-23006948	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1575G>A; p.M525I; 8:23008066-23008066	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.213C>T; p.D71D; 8:23005392-23005392	breast	carcinoma	Substitution - coding silent
c.1937_1938insC; p.R648fs*39; 8:23015714-23015715	oesophagus	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1622T>G; p.V541G; 8:23010539-23010539	breast	carcinoma	Substitution - Missense
c.1509C>T; p.T503T; 8:23008000-23008000	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1104C>T; p.D368D; 8:23007349-23007349	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1327C>T; p.R443C; 8:23007572-23007572	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1540C>A; p.H514N; 8:23008031-23008031	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1738C>T; p.R580C; 8:23010655-23010655	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1738C>T; p.R580C; 8:23010655-23010655	skin	malignant_melanoma	Substitution - Missense
c.829C>T; p.R277C; 8:23007074-23007074	prostate	carcinoma	Substitution - Missense
c.8C>T; p.S3F; 8:23004442-23004442	breast	carcinoma	Substitution - Missense
c.281G>A; p.R94H; 8:23005460-23005460	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2096G>A; p.R699Q; 8:23017381-23017381	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2096G>A; p.R699Q; 8:23017381-23017381	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1400T>C; p.I467T; 8:23007645-23007645	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.859A>G; p.T287A; 8:23007104-23007104	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.857C>G; p.S286C; 8:23007102-23007102	urinary_tract; bladder	carcinoma	Substitution - Missense
c.801C>T; p.D267D; 8:23007046-23007046	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.241C>T; p.R81C; 8:23005420-23005420	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1654C>T; p.R552W; 8:23010571-23010571	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1689C>T; p.F563F; 8:23010606-23010606	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1318G>T; p.E440*; 8:23007563-23007563	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.632G>A; p.R211H; 8:23006877-23006877	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1366G>A; p.E456K; 8:23007611-23007611	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1324G>A; p.E442K; 8:23007569-23007569	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.1324G>A; p.E442K; 8:23007569-23007569	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.1324G>A; p.E442K; 8:23007569-23007569	breast	carcinoma	Substitution - Missense
c.442G>T; p.D148Y; 8:23006105-23006105	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1771G>T; p.E591*; 8:23010688-23010688	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2169C>A; p.S723S; 8:23017454-23017454	thyroid	other; neoplasm	Substitution - coding silent
c.1174G>A; p.A392T; 8:23007419-23007419	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1087C>T; p.R363C; 8:23007332-23007332	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2172G>A; p.S724S; 8:23017457-23017457	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.927G>A; p.S309S; 8:23007172-23007172	skin	malignant_melanoma	Substitution - coding silent
c.420C>A; p.C140*; 8:23006083-23006083	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation