lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	22974
Symbol	TPX2
Synonymous	C20orf1\|C20orf2\|DIL-2\|DIL2\|FLS353\|GD:C20orf1\|HCA519\|HCTP4\|REPP86\|p100
Full name	TPX2, microtubule-associated
Gene description	TPX2, microtubule-associated protein homolog\|TPX2, microtubule-associated, homolog\|differentially expressed in cancerous and non-cancerous lung cells 2\|differentially expressed in lung cells\|hepatocellular carcinoma-associated antigen 519\|hepatocellular c
Cytoband	20q11.2
Gene type	protein-coding
Synonymous	MIM:605917; HGNC:HGNC:1249; Ensembl:ENSG00000088325; HPRD:05802; Vega:OTTHUMG00000032190

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.594T>C; p.C198C; 20:31771668-31771668	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1372C>G; p.H458D; 20:31783880-31783880	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1636G>T; p.E546*; 20:31793974-31793974	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Nonsense
c.1927G>C; p.E643Q; 20:31797497-31797497	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1774C>T; p.P592S; 20:31794489-31794489	prostate	carcinoma	Substitution - Missense
c.161T>C; p.L54P; 20:31760111-31760111	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1076C>T; p.S359F; 20:31782270-31782270	breast	carcinoma	Substitution - Missense
c.1920C>A; p.P640P; 20:31797490-31797490	skin	malignant_melanoma	Substitution - coding silent
c.839A>C; p.E280A; 20:31777595-31777595	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1531A>C; p.I511L; 20:31793869-31793869	urinary_tract; bladder	carcinoma	Substitution - Missense
c.799C>T; p.R267*; 20:31777555-31777555	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2168G>A; p.G723D; 20:31801004-31801004	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.417A>C; p.K139N; 20:31770403-31770403	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.902G>A; p.C301Y; 20:31778832-31778832	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.343G>A; p.A115T; 20:31766669-31766669	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.863G>A; p.R288Q; 20:31777619-31777619	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1903C>G; p.Q635E; 20:31797473-31797473	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.631G>A; p.E211K; 20:31775889-31775889	breast	carcinoma	Substitution - Missense
c.1677G>T; p.Q559H; 20:31794015-31794015	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1260G>T; p.K420N; 20:31783768-31783768	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.546G>T; p.K182N; 20:31771620-31771620	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1372C>T; p.H458Y; 20:31783880-31783880	skin	malignant_melanoma	Substitution - Missense
c.1372C>T; p.H458Y; 20:31783880-31783880	skin	malignant_melanoma	Substitution - Missense
c.1372C>T; p.H458Y; 20:31783880-31783880	skin	malignant_melanoma	Substitution - Missense
c.670G>T; p.E224*; 20:31775928-31775928	central_nervous_system; brain	glioma	Substitution - Nonsense
c.670G>T; p.E224*; 20:31775928-31775928	lung	carcinoma; large_cell_carcinoma	Substitution - Nonsense
c.761T>G; p.V254G; 20:31777517-31777517	skin	malignant_melanoma	Substitution - Missense
c.612G>T; p.Q204H; 20:31775870-31775870	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.939G>T; p.K313N; 20:31778869-31778869	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.939G>T; p.K313N; 20:31778869-31778869	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1138G>A; p.A380T; 20:31782332-31782332	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1391C>A; p.T464N; 20:31783899-31783899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1010G>A; p.R337Q; 20:31778940-31778940	skin	malignant_melanoma	Substitution - Missense
c.268C>G; p.L90V; 20:31766594-31766594	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1260G>A; p.K420K; 20:31783768-31783768	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.849T>A; p.F283L; 20:31777605-31777605	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.872C>T; p.P291L; 20:31777628-31777628	skin	malignant_melanoma	Substitution - Missense
c.800G>A; p.R267Q; 20:31777556-31777556	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.899G>T; p.G300V; 20:31778829-31778829	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1009C>T; p.R337*; 20:31778939-31778939	pancreas	carcinoma	Substitution - Nonsense
c.2230C>T; p.R744*; 20:31801066-31801066	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.637C>T; p.Q213*; 20:31775895-31775895	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.967A>G; p.T323A; 20:31778897-31778897	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1632C>G; p.D544E; 20:31793970-31793970	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.78A>T; p.G26G; 20:31757554-31757554	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.890T>C; p.V297A; 20:31778820-31778820	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1306G>A; p.E436K; 20:31783814-31783814	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1519G>A; p.E507K; 20:31793857-31793857	skin	malignant_melanoma	Substitution - Missense
c.214A>G; p.T72A; 20:31760164-31760164	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1883G>A; p.R628H; 20:31797453-31797453	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1883G>A; p.R628H; 20:31797453-31797453	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.158G>T; p.G53V; 20:31760108-31760108	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1376C>T; p.S459F; 20:31783884-31783884	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2061G>A; p.Q687Q; 20:31798480-31798480	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1314G>T; p.E438D; 20:31783822-31783822	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.174A>T; p.K58N; 20:31760124-31760124	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1341G>T; p.K447N; 20:31783849-31783849	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1882C>A; p.R628S; 20:31797452-31797452	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.179C>T; p.P60L; 20:31760129-31760129	skin	malignant_melanoma	Substitution - Missense
c.229+1G>A; p.?; 20:31760180-31760180	liver	carcinoma	Unknown
c.1109C>A; p.P370H; 20:31782303-31782303	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1109C>A; p.P370H; 20:31782303-31782303	large_intestine; colon	carcinoma	Substitution - Missense
c.1109C>A; p.P370H; 20:31782303-31782303	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1230A>G; p.R410R; 20:31783738-31783738	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.229+1G>A; p.?; 20:31760180-31760180	liver	carcinoma	Unknown
c.71A>G; p.D24G; 20:31757547-31757547	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.113A>G; p.K38R; 20:31760063-31760063	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1447G>A; p.V483I; 20:31792768-31792768	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1516G>T; p.D506Y; 20:31793854-31793854	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.262G>T; p.E88*; 20:31766588-31766588	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.4T>C; p.S2P; 20:31757480-31757480	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2134-1G>C; p.?; 20:31800969-31800969	central_nervous_system; brain	glioma	Unknown
c.452T>C; p.I151T; 20:31770438-31770438	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.107-1G>T; p.?; 20:31760056-31760056	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1669G>T; p.E557*; 20:31794007-31794007	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1669G>T; p.E557*; 20:31794007-31794007	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1627C>T; p.R543*; 20:31793965-31793965	skin	malignant_melanoma	Substitution - Nonsense
c.2138A>G; p.H713R; 20:31800974-31800974	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.597G>A; p.M199I; 20:31771671-31771671	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1504G>T; p.D502Y; 20:31792825-31792825	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1294G>A; p.G432S; 20:31783802-31783802	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1735C>T; p.L579L; 20:31794450-31794450	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1207A>T; p.K403*; 20:31783715-31783715	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.1137G>T; p.R379R; 20:31782331-31782331	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1569T>C; p.F523F; 20:31793907-31793907	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1617G>C; p.S539S; 20:31793955-31793955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1910_1911CC>TT; p.P637L; 20:31797480-31797481	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.299G>T; p.C100F; 20:31766625-31766625	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1969C>T; p.Q657*; 20:31798388-31798388	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1969C>T; p.Q657*; 20:31798388-31798388	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1411G>T; p.V471L; 20:31783919-31783919	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1843G>A; p.E615K; 20:31797413-31797413	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1673T>C; p.L558P; 20:31794011-31794011	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.609G>A; p.K203K; 20:31775867-31775867	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1132G>A; p.A378T; 20:31782326-31782326	liver	carcinoma	Substitution - Missense
c.508G>C; p.E170Q; 20:31771582-31771582	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2231G>A; p.R744Q; 20:31801067-31801067	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.880C>T; p.P294S; 20:31777636-31777636	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1022G>T; p.R341I; 20:31778952-31778952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1196+1G>A; p.?; 20:31782391-31782391	stomach	carcinoma; adenocarcinoma	Unknown
c.1392T>A; p.T464T; 20:31783900-31783900	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1945G>A; p.E649K; 20:31797515-31797515	urinary_tract; bladder	carcinoma	Substitution - Missense
c.631G>T; p.E211*; 20:31775889-31775889	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.405G>A; p.K135K; 20:31770391-31770391	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.826G>A; p.E276K; 20:31777582-31777582	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1209A>G; p.K403K; 20:31783717-31783717	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1209A>G; p.K403K; 20:31783717-31783717	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1268C>A; p.P423H; 20:31783776-31783776	skin	malignant_melanoma	Substitution - Missense
c.1581C>T; p.I527I; 20:31793919-31793919	skin	malignant_melanoma	Substitution - coding silent
c.1581C>T; p.I527I; 20:31793919-31793919	skin	malignant_melanoma	Substitution - coding silent
c.1486C>T; p.R496*; 20:31792807-31792807	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1486C>T; p.R496*; 20:31792807-31792807	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.48C>T; p.F16F; 20:31757524-31757524	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1486C>T; p.R496*; 20:31792807-31792807	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1486C>T; p.R496*; 20:31792807-31792807	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1405G>T; p.D469Y; 20:31783913-31783913	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.59C>T; p.S20L; 20:31757535-31757535	skin	malignant_melanoma	Substitution - Missense
c.1405G>T; p.D469Y; 20:31783913-31783913	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1518C>T; p.D506D; 20:31793856-31793856	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1518C>T; p.D506D; 20:31793856-31793856	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.21T>G; p.S7S; 20:31757497-31757497	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1580T>A; p.I527N; 20:31793918-31793918	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.739G>T; p.V247L; 20:31777495-31777495	lung	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation