lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	22900
Symbol	CARD8
Synonymous	CARDINAL\|DACAR\|DAKAR\|NDPP\|NDPP1\|TUCAN
Full name	caspase recruitment domain family, member 8
Gene description	CARD inhibitor of NF-kappaB-activating ligands\|apoptotic protein NDPP1\|caspase recruitment domain-containing protein 8\|tumor up-regulated CARD-containing antagonist of CASP9\|tumor up-regulated CARD-containing antagonist of caspase nine
Cytoband	19q13.33
Gene type	protein-coding
Synonymous	MIM:609051; HGNC:HGNC:17057; Ensembl:ENSG00000105483; HPRD:16425

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.526G>T; p.A176S; 19:48230629-48230629	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1144C>T; p.L382L; 19:48211862-48211862	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.728A>G; p.D243G; 19:48221845-48221845	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.902C>T; p.A301V; 19:48218954-48218954	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.619A>G; p.I207V; 19:48230536-48230536	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.160C>T; p.R54C; 19:48231727-48231727	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.160C>T; p.R54C; 19:48231727-48231727	skin	malignant_melanoma	Substitution - Missense
c.160C>T; p.R54C; 19:48231727-48231727	skin; trunk	malignant_melanoma	Substitution - Missense
c.458-10C>G; p.?; 19:48230707-48230707	kidney	other; neoplasm	Unknown
c.453C>G; p.L151L; 19:48230781-48230781	breast	carcinoma	Substitution - coding silent
c.1178A>G; p.N393S; 19:48211828-48211828	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1221C>T; p.A407A; 19:48211785-48211785	skin	malignant_melanoma	Substitution - coding silent
c.22C>T; p.H8Y; 19:48234457-48234457	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.844G>T; p.E282*; 19:48219012-48219012	pancreas	carcinoma	Substitution - Nonsense
c.96G>T; p.E32D; 19:48231791-48231791	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.526G>C; p.A176P; 19:48230629-48230629	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1287G>T; p.Q429H; 19:48211719-48211719	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.161G>A; p.R54H; 19:48231726-48231726	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.33C>T; p.S11S; 19:48234446-48234446	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.662C>A; p.P221H; 19:48230493-48230493	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.206A>G; p.D69G; 19:48231681-48231681	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.740G>A; p.R247H; 19:48221833-48221833	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1225G>A; p.D409N; 19:48211781-48211781	prostate	carcinoma	Substitution - Missense
c.72_73CC>TT; p.P25S; 19:48234406-48234407	skin	malignant_melanoma	Substitution - Missense
c.124A>G; p.K42E; 19:48231763-48231763	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2T>C; p.M1T; 19:48234477-48234477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.920C>T; p.P307L; 19:48218936-48218936	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.127_128insAA; p.V43fs*26; 19:48231759-48231760	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.127_128insAA; p.V43fs*26; 19:48231759-48231760	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.127_128insAA; p.V43fs*26; 19:48231759-48231760	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.1150G>A; p.E384K; 19:48211856-48211856	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1228G>A; p.V410M; 19:48211778-48211778	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.658delC; p.H220fs*18; 19:48230497-48230497	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.141C>T; p.I47I; 19:48231746-48231746	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1283A>C; p.Q428P; 19:48211723-48211723	skin	malignant_melanoma	Substitution - Missense
c.364C>T; p.Q122*; 19:48230870-48230870	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.598G>A; p.A200T; 19:48230557-48230557	liver	carcinoma	Substitution - Missense
c.424G>A; p.E142K; 19:48230810-48230810	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.469G>A; p.V157I; 19:48230686-48230686	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.611G>A; p.R204H; 19:48230544-48230544	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.58C>A; p.L20M; 19:48234421-48234421	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.237C>T; p.F79F; 19:48230997-48230997	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.237C>T; p.F79F; 19:48230997-48230997	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1217T>A; p.L406Q; 19:48211789-48211789	breast	carcinoma	Substitution - Missense
c.205G>T; p.D69Y; 19:48231682-48231682	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.450C>T; p.S150S; 19:48230784-48230784	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.450C>T; p.S150S; 19:48230784-48230784	skin	malignant_melanoma	Substitution - coding silent
c.700G>A; p.D234N; 19:48230455-48230455	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.182G>A; p.G61E; 19:48231705-48231705	urinary_tract; bladder	carcinoma	Substitution - Missense
c.528C>T; p.A176A; 19:48230627-48230627	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.528C>T; p.A176A; 19:48230627-48230627	skin	malignant_melanoma	Substitution - coding silent
c.142G>A; p.E48K; 19:48231745-48231745	skin	malignant_melanoma	Substitution - Missense
c.1149G>T; p.V383V; 19:48211857-48211857	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.596T>C; p.I199T; 19:48230559-48230559	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.30T>A; p.C10*; 19:48234449-48234449	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.30T>A; p.C10*; 19:48234449-48234449	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Nonsense
c.30T>A; p.C10*; 19:48234449-48234449	thyroid	other; neoplasm	Substitution - Nonsense
c.30T>A; p.C10*; 19:48234449-48234449	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Nonsense
c.1031G>T; p.G344V; 19:48211975-48211975	liver	carcinoma	Substitution - Missense
c.667G>T; p.D223Y; 19:48230488-48230488	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1031G>T; p.G344V; 19:48211975-48211975	liver	carcinoma	Substitution - Missense
c.925C>G; p.Q309E; 19:48218931-48218931	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.925C>G; p.Q309E; 19:48218931-48218931	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.409G>C; p.E137Q; 19:48230825-48230825	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.597C>T; p.I199I; 19:48230558-48230558	skin	malignant_melanoma	Substitution - coding silent
c.553C>T; p.L185L; 19:48230602-48230602	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1003G>A; p.A335T; 19:48215367-48215367	haematopoietic_and_lymphoid_tissue; abdomen	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.703G>A; p.A235T; 19:48230452-48230452	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.664G>A; p.E222K; 19:48230491-48230491	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.664G>A; p.E222K; 19:48230491-48230491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.308C>T; p.T103M; 19:48230926-48230926	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.66_67insG; p.T23fs*20; 19:48234412-48234413	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.618C>T; p.S206S; 19:48230537-48230537	skin	malignant_melanoma	Substitution - coding silent
c.113C>T; p.S38F; 19:48231774-48231774	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.860_870del11; p.Y287fs*21; 19:48218986-48218996	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1209A>T; p.K403N; 19:48211797-48211797	breast	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation