lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	226
Symbol	ALDOA
Synonymous	ALDA\|GSD12\|HEL-S-87p
Full name	aldolase A, fructose-bisphosphate
Gene description	epididymis secretory sperm binding protein Li 87p\|fructose-1,6-bisphosphate triosephosphate-lyase\|fructose-bisphosphate aldolase A\|lung cancer antigen NY-LU-1\|muscle-type aldolase
Cytoband	16p11.2
Gene type	protein-coding
Synonymous	MIM:103850; HGNC:HGNC:414; Ensembl:ENSG00000149925; HPRD:00070; Vega:OTTHUMG00000132107

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.864C>T; p.N288N; 16:30069894-30069894	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.970G>T; p.A324S; 16:30070000-30070000	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.186G>A; p.L62L; 16:30067523-30067523	prostate	carcinoma	Substitution - coding silent
c.1075G>A; p.V359I; 16:30070192-30070192	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.652A>T; p.S218C; 16:30069526-30069526	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.652A>T; p.S218C; 16:30069526-30069526	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.732T>G; p.F244L; 16:30069606-30069606	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.574C>T; p.L192F; 16:30069339-30069339	skin	malignant_melanoma	Substitution - Missense
c.241C>T; p.H81Y; 16:30067578-30067578	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.601C>T; p.R201C; 16:30069366-30069366	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.587A>G; p.D196G; 16:30069352-30069352	large_intestine; colon	carcinoma	Substitution - Missense
c.380-1G>A; p.?; 16:30068817-30068817	lung	carcinoma; adenocarcinoma	Unknown
c.328G>C; p.D110H; 16:30068649-30068649	breast	carcinoma	Substitution - Missense
c.246G>A; p.E82E; 16:30067583-30067583	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - coding silent
c.1033C>T; p.P345S; 16:30070150-30070150	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.202G>A; p.D68N; 16:30067539-30067539	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.767C>T; p.A256V; 16:30069641-30069641	breast	carcinoma	Substitution - Missense
c.363C>T; p.G121G; 16:30068684-30068684	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.385G>C; p.D129H; 16:30068823-30068823	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.789C>T; p.P263P; 16:30069663-30069663	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.417G>A; p.K139K; 16:30068855-30068855	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.884C>A; p.P295H; 16:30069914-30069914	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.955G>T; p.E319*; 16:30069985-30069985	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.423C>T; p.D141D; 16:30068861-30068861	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.226G>T; p.G76C; 16:30067563-30067563	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.436G>A; p.A146T; 16:30068874-30068874	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.776G>A; p.R259H; 16:30069650-30069650	prostate	carcinoma	Substitution - Missense
c.577C>T; p.P193S; 16:30069342-30069342	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.302A>T; p.K101M; 16:30067639-30067639	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.805A>G; p.T269A; 16:30069835-30069835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.510T>C; p.V170V; 16:30068948-30068948	ovary	other; neoplasm	Substitution - coding silent
c.1022G>A; p.G341E; 16:30070139-30070139	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.783_784insC; p.A264fs*14; 16:30069657-30069658	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.580G>A; p.D194N; 16:30069345-30069345	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1039G>T; p.G347C; 16:30070156-30070156	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.568G>A; p.E190K; 16:30069333-30069333	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.825G>C; p.Q275H; 16:30069855-30069855	breast	carcinoma	Substitution - Missense
c.568G>A; p.E190K; 16:30069333-30069333	urinary_tract; bladder	carcinoma	Substitution - Missense
c.61C>T; p.H21Y; 16:30067315-30067315	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.655G>A; p.D219N; 16:30069529-30069529	breast	carcinoma	Substitution - Missense
c.1061G>T; p.S354I; 16:30070178-30070178	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.539A>G; p.Q180R; 16:30068977-30068977	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.157G>A; p.E53K; 16:30067494-30067494	urinary_tract; bladder	carcinoma	Substitution - Missense
c.157G>A; p.E53K; 16:30067494-30067494	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.64C>T; p.R22C; 16:30067318-30067318	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.64C>T; p.R22C; 16:30067318-30067318	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.736C>T; p.H246Y; 16:30069610-30069610	breast	carcinoma	Substitution - Missense
c.755C>T; p.A252V; 16:30069629-30069629	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.957G>A; p.E319E; 16:30069987-30069987	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.598A>T; p.K200*; 16:30069363-30069363	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1069C>T; p.L357F; 16:30070186-30070186	skin	malignant_melanoma	Substitution - Missense
c.586G>A; p.D196N; 16:30069351-30069351	pancreas	carcinoma	Substitution - Missense
c.586G>A; p.D196N; 16:30069351-30069351	pancreas	carcinoma	Substitution - Missense
c.738T>G; p.H246Q; 16:30069612-30069612	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1008C>T; p.S336S; 16:30070125-30070125	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.479C>T; p.S160L; 16:30068917-30068917	breast	carcinoma	Substitution - Missense
c.278C>T; p.P93L; 16:30067615-30067615	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.780A>G; p.T260T; 16:30069654-30069654	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.952A>G; p.K318E; 16:30069982-30069982	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.445C>T; p.R149C; 16:30068883-30068883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.790G>A; p.A264T; 16:30069664-30069664	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.252C>G; p.L84L; 16:30067589-30067589	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.374C>T; p.T125I; 16:30068695-30068695	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.374C>T; p.T125I; 16:30068695-30068695	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.374C>T; p.T125I; 16:30068695-30068695	large_intestine; colon	carcinoma	Substitution - Missense
c.374C>T; p.T125I; 16:30068695-30068695	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>T; p.A324V; 16:30070001-30070001	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation