lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2241
Symbol	FER
Synonymous	PPP1R74\|TYK3\|p94-Fer
Full name	fer (fps/fes related) tyrosine kinase
Gene description	feline encephalitis virus-related kinase FER\|fujinami poultry sarcoma/Feline sarcoma-related protein Fer\|phosphoprotein NCP94\|protein phosphatase 1, regulatory subunit 74\|proto-oncogene c-Fer\|tyrosine kinase 3\|tyrosine-protein kinase Fer
Cytoband	5q21
Gene type	protein-coding
Synonymous	MIM:176942; HGNC:HGNC:3655; Ensembl:ENSG00000151422; HPRD:01491

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1482T>C; p.L494L; 5:108954881-108954881	breast	carcinoma	Substitution - coding silent
c.1701A>G; p.E567E; 5:109037466-109037466	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.673A>G; p.I225V; 5:108871372-108871372	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.673A>G; p.I225V; 5:108871372-108871372	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.456G>A; p.E152E; 5:108835782-108835782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.456G>A; p.E152E; 5:108835782-108835782	thyroid	other; neoplasm	Substitution - coding silent
c.616C>T; p.L206L; 5:108867901-108867901	liver	carcinoma	Substitution - coding silent
c.1819C>A; p.Q607K; 5:109044785-109044785	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2001C>T; p.D667D; 5:109100472-109100472	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.292C>A; p.H98N; 5:108832854-108832854	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.464A>C; p.K155T; 5:108835790-108835790	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1742C>T; p.T581I; 5:109044708-109044708	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.770G>A; p.S257N; 5:108871469-108871469	ovary	other; neoplasm	Substitution - Missense
c.1476T>C; p.Y492Y; 5:108954875-108954875	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2188G>A; p.E730K; 5:109180886-109180886	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2390G>C; p.W797S; 5:109187496-109187496	ovary	other; neoplasm	Substitution - Missense
c.1396C>T; p.P466S; 5:108954795-108954795	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.973A>T; p.N325Y; 5:108883445-108883445	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.281C>G; p.S94C; 5:108832843-108832843	breast	carcinoma	Substitution - Missense
c.498G>T; p.K166N; 5:108867783-108867783	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1293delA; p.I432fs*16; 5:108946186-108946186	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2379G>A; p.M793I; 5:109187485-109187485	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.482G>T; p.G161V; 5:108867767-108867767	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.198C>T; p.N66N; 5:108798380-108798380	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1037A>C; p.K346T; 5:108883509-108883509	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.556G>A; p.V186I; 5:108867841-108867841	breast	carcinoma	Substitution - Missense
c.578A>T; p.Q193L; 5:108867863-108867863	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1193C>T; p.P398L; 5:108897805-108897805	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.578A>T; p.Q193L; 5:108867863-108867863	urinary_tract; bladder	carcinoma	Substitution - Missense
c.169A>G; p.S57G; 5:108798351-108798351	stomach	carcinoma	Substitution - Missense
c.679G>A; p.D227N; 5:108871378-108871378	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2120G>A; p.R707H; 5:109180818-109180818	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2111G>A; p.G704E; 5:109180809-109180809	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.333G>T; p.K111N; 5:108832895-108832895	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.137T>A; p.L46*; 5:108798319-108798319	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.436G>T; p.E146*; 5:108835762-108835762	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.436G>T; p.E146*; 5:108835762-108835762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.436G>T; p.E146*; 5:108835762-108835762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.990T>G; p.V330V; 5:108883462-108883462	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1421_1422insA; p.Q477fs*15; 5:108954820-108954821	oesophagus	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1421_1422insA; p.Q477fs*15; 5:108954820-108954821	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.807A>T; p.T269T; 5:108872096-108872096	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2204-8T>C; p.?; 5:109186192-109186192	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.649G>T; p.E217*; 5:108867934-108867934	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1361C>T; p.P454L; 5:108954760-108954760	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1178G>A; p.G393E; 5:108897790-108897790	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.165G>A; p.K55K; 5:108798347-108798347	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.118A>T; p.K40*; 5:108798300-108798300	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1614C>G; p.I538M; 5:108959305-108959305	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1047T>C; p.D349D; 5:108897659-108897659	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.719T>C; p.I240T; 5:108871418-108871418	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.719T>C; p.I240T; 5:108871418-108871418	large_intestine; colon	carcinoma	Substitution - Missense
c.719T>C; p.I240T; 5:108871418-108871418	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1658A>G; p.D553G; 5:109037423-109037423	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.995A>T; p.E332V; 5:108883467-108883467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1349T>G; p.I450S; 5:108954748-108954748	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1813T>C; p.F605L; 5:109044779-109044779	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2102G>A; p.S701N; 5:109180800-109180800	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2102G>A; p.S701N; 5:109180800-109180800	pancreas	carcinoma	Substitution - Missense
c.586C>T; p.Q196*; 5:108867871-108867871	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.55G>T; p.D19Y; 5:108798237-108798237	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1212A>G; p.E404E; 5:108897824-108897824	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1212A>G; p.E404E; 5:108897824-108897824	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1212A>G; p.E404E; 5:108897824-108897824	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2184A>G; p.A728A; 5:109180882-109180882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2184A>G; p.A728A; 5:109180882-109180882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1801T>C; p.L601L; 5:109044767-109044767	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2184A>G; p.A728A; 5:109180882-109180882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1548C>T; p.F516F; 5:108959239-108959239	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2241C>A; p.G747G; 5:109186237-109186237	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.1533+1G>A; p.?; 5:108954933-108954933	urinary_tract; bladder	carcinoma	Unknown
c.2027A>G; p.E676G; 5:109100498-109100498	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1006A>G; p.R336G; 5:108883478-108883478	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.682G>A; p.E228K; 5:108871381-108871381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1739G>A; p.G580D; 5:109044705-109044705	skin; upper_back	malignant_melanoma	Substitution - Missense
c.1289G>C; p.G430A; 5:108946182-108946182	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1245G>T; p.K415N; 5:108946138-108946138	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.508C>T; p.R170*; 5:108867793-108867793	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Nonsense
c.508C>T; p.R170*; 5:108867793-108867793	large_intestine; rectum	NS	Substitution - Nonsense
c.1274G>A; p.R425H; 5:108946167-108946167	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2400A>G; p.K800K; 5:109187506-109187506	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2383A>G; p.K795E; 5:109187489-109187489	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.845C>T; p.S282F; 5:108872134-108872134	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>T; p.V243F; 5:108871426-108871426	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2182G>T; p.A728S; 5:109180880-109180880	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.87G>T; p.K29N; 5:108798269-108798269	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.87G>T; p.K29N; 5:108798269-108798269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2183C>T; p.A728V; 5:109180881-109180881	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.788T>C; p.F263S; 5:108871487-108871487	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1613T>C; p.I538T; 5:108959304-108959304	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1878T>C; p.V626V; 5:109047152-109047152	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1854C>T; p.P618P; 5:109047128-109047128	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1598C>A; p.T533K; 5:108959289-108959289	breast	carcinoma	Substitution - Missense
c.265G>A; p.A89T; 5:108832827-108832827	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1379G>A; p.W460*; 5:108954778-108954778	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1960G>C; p.D654H; 5:109100431-109100431	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1594T>C; p.Y532H; 5:108959285-108959285	skin; shoulder	malignant_melanoma	Substitution - Missense
c.572G>A; p.G191E; 5:108867857-108867857	skin	malignant_melanoma	Substitution - Missense
c.2226C>T; p.D742D; 5:109186222-109186222	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2252G>C; p.W751S; 5:109186248-109186248	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.582C>T; p.L194L; 5:108867867-108867867	NS	NS	Substitution - coding silent
c.2354G>T; p.C785F; 5:109187460-109187460	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1844A>G; p.Y615C; 5:109047118-109047118	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2252G>C; p.W751S; 5:109186248-109186248	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1237-1G>T; p.?; 5:108946129-108946129	kidney	other; neoplasm	Unknown
c.1380G>C; p.W460C; 5:108954779-108954779	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.869T>A; p.L290H; 5:108872158-108872158	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1796A>G; p.Q599R; 5:109044762-109044762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.382G>C; p.V128L; 5:108835708-108835708	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2277T>C; p.C759C; 5:109186273-109186273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1436A>G; p.D479G; 5:108954835-108954835	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2426A>G; p.E809G; 5:109187532-109187532	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2217A>G; p.S739S; 5:109186213-109186213	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1422delA; p.K476fs*53; 5:108954821-108954821	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1422delA; p.K476fs*53; 5:108954821-108954821	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1422delA; p.K476fs*53; 5:108954821-108954821	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1422delA; p.K476fs*53; 5:108954821-108954821	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1422delA; p.K476fs*53; 5:108954821-108954821	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2207G>A; p.R736K; 5:109186203-109186203	breast	carcinoma	Substitution - Missense
c.1422delA; p.K476fs*53; 5:108954821-108954821	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1422delA; p.K476fs*53; 5:108954821-108954821	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.598T>G; p.Y200D; 5:108867883-108867883	ovary	other; neoplasm	Substitution - Missense
c.598T>G; p.Y200D; 5:108867883-108867883	ovary	other; neoplasm	Substitution - Missense
c.1690A>G; p.I564V; 5:109037455-109037455	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2272G>T; p.V758F; 5:109186268-109186268	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1002G>T; p.E334D; 5:108883474-108883474	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1002G>T; p.E334D; 5:108883474-108883474	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2046C>G; p.H682Q; 5:109100517-109100517	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1256C>G; p.S419C; 5:108946149-108946149	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2126A>G; p.E709G; 5:109180824-109180824	breast	carcinoma	Substitution - Missense
c.2182G>A; p.A728T; 5:109180880-109180880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.701G>A; p.S234N; 5:108871400-108871400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2288G>A; p.G763E; 5:109186284-109186284	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.961C>T; p.Q321*; 5:108883433-108883433	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1625C>A; p.S542*; 5:108959316-108959316	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1408G>T; p.A470S; 5:108954807-108954807	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1170A>C; p.E390D; 5:108897782-108897782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1553G>A; p.G518D; 5:108959244-108959244	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.642G>T; p.M214I; 5:108867927-108867927	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.131C>G; p.S44C; 5:108798313-108798313	NS	NS	Substitution - Missense
c.84A>G; p.V28V; 5:108798266-108798266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.943G>T; p.E315*; 5:108883415-108883415	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.943G>T; p.E315*; 5:108883415-108883415	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1826C>T; p.A609V; 5:109044792-109044792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1380G>A; p.W460*; 5:108954779-108954779	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.528G>T; p.M176I; 5:108867813-108867813	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.767C>A; p.P256H; 5:108871466-108871466	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.923T>G; p.M308R; 5:108872212-108872212	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.24G>T; p.K8N; 5:108798206-108798206	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.278A>T; p.N93I; 5:108832840-108832840	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1480C>T; p.L494F; 5:108954879-108954879	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1576C>T; p.Q526*; 5:108959267-108959267	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1543C>T; p.R515*; 5:108959234-108959234	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1543C>T; p.R515*; 5:108959234-108959234	skin	malignant_melanoma	Substitution - Nonsense
c.1380G>T; p.W460C; 5:108954779-108954779	lung	carcinoma	Substitution - Missense
c.1380G>T; p.W460C; 5:108954779-108954779	lung	carcinoma	Substitution - Missense
c.355C>T; p.Q119*; 5:108832917-108832917	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1157delA; p.V388fs*12; 5:108897769-108897769	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1751_1752AT>GC; p.D584G; 5:109044717-109044718	skin	malignant_melanoma	Substitution - Missense
c.1210G>C; p.E404Q; 5:108897822-108897822	ovary	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1210G>C; p.E404Q; 5:108897822-108897822	ovary	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.924-3T>A; p.?; 5:108883393-108883393	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Unknown
c.2410C>T; p.R804C; 5:109187516-109187516	skin	malignant_melanoma	Substitution - Missense
c.2410C>T; p.R804C; 5:109187516-109187516	skin	malignant_melanoma	Substitution - Missense
c.2410C>T; p.R804C; 5:109187516-109187516	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.447T>G; p.S149S; 5:108835773-108835773	stomach	adenocarcinoma	Substitution - coding silent
c.2160G>A; p.K720K; 5:109180858-109180858	skin	malignant_melanoma	Substitution - coding silent
c.763G>C; p.D255H; 5:108871462-108871462	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation