lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2222
Symbol	FDFT1
Synonymous	DGPT\|ERG9\|SQS\|SS
Full name	farnesyl-diphosphate farnesyltransferase 1
Gene description	FPP:FPP farnesyltransferase\|presqualene-di-diphosphate synthase\|squalene synthase\|squalene synthetase
Cytoband	8p23.1-p22
Gene type	protein-coding
Synonymous	MIM:184420; HGNC:HGNC:3629; Ensembl:ENSG00000079459; HPRD:01694; Vega:OTTHUMG00000090801

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.381+1G>A; p.?; 8:11809851-11809851	stomach	carcinoma; adenocarcinoma	Unknown
c.1136G>A; p.R379Q; 8:11838491-11838491	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.994C>A; p.P332T; 8:11831632-11831632	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.282delC; p.P95fs*48; 8:11809751-11809751	skin; scalp	malignant_melanoma	Deletion - Frameshift
c.11T>C; p.V4A; 8:11802843-11802843	breast	carcinoma	Substitution - Missense
c.708G>T; p.W236C; 8:11830249-11830249	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.949C>T; p.R317W; 8:11831587-11831587	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.430G>A; p.A144T; 8:11821798-11821798	pancreas	carcinoma	Substitution - Missense
c.430G>A; p.A144T; 8:11821798-11821798	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1035T>G; p.I345M; 8:11838390-11838390	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1035T>G; p.I345M; 8:11838390-11838390	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.735delT; p.F246fs*14; 8:11830276-11830276	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.746C>G; p.P249R; 8:11830287-11830287	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.337G>A; p.E113K; 8:11809806-11809806	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.203C>T; p.A68V; 8:11809672-11809672	breast	carcinoma	Substitution - Missense
c.134A>G; p.K45R; 8:11808828-11808828	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.278A>G; p.K93R; 8:11809747-11809747	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.227T>C; p.L76P; 8:11809696-11809696	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1067C>G; p.S356C; 8:11838422-11838422	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.270G>A; p.V90V; 8:11809739-11809739	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.433G>A; p.D145N; 8:11821801-11821801	breast	carcinoma	Substitution - Missense
c.174C>G; p.I58M; 8:11808868-11808868	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.386C>A; p.S129Y; 8:11821754-11821754	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.386C>A; p.S129Y; 8:11821754-11821754	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1253G>A; p.418; 8:11838608-11838608	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.554G>A; p.R185H; 8:11826067-11826067	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.145C>G; p.Q49E; 8:11808839-11808839	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.145C>G; p.Q49E; 8:11808839-11808839	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.792C>G; p.T264T; 8:11830333-11830333	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.426G>C; p.V142V; 8:11821794-11821794	breast	carcinoma	Substitution - coding silent
c.1163C>T; p.S388L; 8:11838518-11838518	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.348G>A; p.E116E; 8:11809817-11809817	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.156C>T; p.R52R; 8:11808850-11808850	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.577G>A; p.E193K; 8:11826090-11826090	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.577G>A; p.E193K; 8:11826090-11826090	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.521A>G; p.Y174C; 8:11826034-11826034	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.85C>G; p.P29A; 8:11802917-11802917	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.934G>T; p.G312W; 8:11831572-11831572	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1103C>T; p.T368M; 8:11838458-11838458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.669C>T; p.D223D; 8:11826182-11826182	skin	malignant_melanoma	Substitution - coding silent
c.1055C>T; p.S352L; 8:11838410-11838410	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.840C>G; p.L280L; 8:11830381-11830381	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.975G>A; p.M325I; 8:11831613-11831613	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.129C>T; p.C43C; 8:11808823-11808823	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1251C>G; p.H417Q; 8:11838606-11838606	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.283C>T; p.P95S; 8:11809752-11809752	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.690C>A; p.F230L; 8:11826203-11826203	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.446G>T; p.R149I; 8:11821814-11821814	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1076C>T; p.T359I; 8:11838431-11838431	liver	carcinoma	Substitution - Missense
c.328C>T; p.R110W; 8:11809797-11809797	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.972G>C; p.L324L; 8:11831610-11831610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1210C>G; p.L404V; 8:11838565-11838565	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.644A>G; p.N215S; 8:11826157-11826157	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.614A>G; p.N205S; 8:11826127-11826127	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.201C>T; p.N67N; 8:11809670-11809670	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.201C>T; p.N67N; 8:11809670-11809670	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.201C>T; p.N67N; 8:11809670-11809670	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.534G>A; p.L178L; 8:11826047-11826047	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation