Cancer metastasis database

Annotation category 5

Gene information

Gene ID 221120
Symbol

ALKBH3

Synonymous

ABH3|DEPC-1|DEPC1|PCA1

Full name

alkB, alkylation repair homolog 3 (E. coli)

Gene description

alkylated DNA repair protein alkB homolog 3|alpha-ketoglutarate-dependent dioxygenase alkB homolog 3|prostate cancer antigen 1|prostate cancer antigen-1

Cytoband

11p11.2

Gene type

protein-coding

Synonymous

MIM:610603; HGNC:HGNC:30141; Ensembl:ENSG00000166199; HPRD:16793; Vega:OTTHUMG00000166417

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.231G>T; p.V77V; 11:43886618-43886618

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.486G>A; p.K162K; 11:43901542-43901542

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.772C>T; p.R258*; 11:43919921-43919921

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.216T>C; p.I72I; 11:43884015-43884015

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.829G>A; p.V277I; 11:43919978-43919978

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.760G>A; p.D254N; 11:43919128-43919128

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.564G>A; p.V188V; 11:43901620-43901620

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.824G>A; p.R275Q; 11:43919973-43919973

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.376A>G; p.T126A; 11:43892046-43892046

 skinmalignant_melanomaSubstitution - Missense

c.732G>C; p.L244F; 11:43919100-43919100

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.800A>T; p.E267V; 11:43919949-43919949

 skinmalignant_melanomaSubstitution - Missense

c.684C>G; p.D228E; 11:43919052-43919052

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.684C>G; p.D228E; 11:43919052-43919052

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.238A>C; p.I80L; 11:43886625-43886625

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.17G>A; p.R6Q; 11:43882669-43882669

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.17G>A; p.R6Q; 11:43882669-43882669

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.511C>A; p.H171N; 11:43901567-43901567

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.296T>C; p.V99A; 11:43889754-43889754

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.503A>C; p.N168T; 11:43901559-43901559

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.46G>A; p.A16T; 11:43882698-43882698

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.191G>A; p.R64H; 11:43883990-43883990

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.52G>A; p.V18I; 11:43882704-43882704

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.769-7C>T; p.?; 11:43919911-43919911

 pancreascarcinomaUnknown

c.334G>C; p.D112H; 11:43889792-43889792

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.637C>T; p.R213C; 11:43901693-43901693

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.404G>A; p.W135*; 11:43892074-43892074

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.778C>T; p.P260S; 11:43919927-43919927

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.552G>C; p.E184D; 11:43901608-43901608

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.552G>C; p.E184D; 11:43901608-43901608

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.552G>C; p.E184D; 11:43901608-43901608

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.552G>C; p.E184D; 11:43901608-43901608

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.669+1G>T; p.?; 11:43901726-43901726

 lungcarcinoma; squamous_cell_carcinomaUnknown

c.804G>A; p.P268P; 11:43919953-43919953

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.856T>C; p.W286R; 11:43920005-43920005

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.544C>T; p.R182C; 11:43901600-43901600

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.718G>A; p.D240N; 11:43919086-43919086

 breastcarcinomaSubstitution - Missense

c.544C>T; p.R182C; 11:43901600-43901600

 NSmalignant_melanomaSubstitution - Missense

c.544C>T; p.R182C; 11:43901600-43901600

 NSmalignant_melanomaSubstitution - Missense

c.718G>T; p.D240Y; 11:43919086-43919086

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.240C>T; p.I80I; 11:43886627-43886627

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.499G>C; p.E167Q; 11:43901555-43901555

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.276G>T; p.L92F; 11:43889734-43889734

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.276G>T; p.L92F; 11:43889734-43889734

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.459C>T; p.H153H; 11:43892129-43892129

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.266+5G>A; p.?; 11:43886658-43886658

 kidneyother; neoplasmUnknown

c.641C>T; p.T214I; 11:43901697-43901697

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.501G>A; p.E167E; 11:43901557-43901557

 ovaryother; neoplasmSubstitution - coding silent

c.491G>A; p.R164H; 11:43901547-43901547

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.490C>A; p.R164S; 11:43901546-43901546

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.12A>C; p.K4N; 11:43882664-43882664

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.561C>T; p.S187S; 11:43901617-43901617

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.222A>G; p.R74R; 11:43886609-43886609

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.190C>T; p.R64C; 11:43883989-43883989

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.750G>A; p.A250A; 11:43919118-43919118

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.750G>A; p.A250A; 11:43919118-43919118

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.750G>A; p.A250A; 11:43919118-43919118

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.605C>T; p.P202L; 11:43901661-43901661

 skinmalignant_melanomaSubstitution - Missense

c.604C>T; p.P202S; 11:43901660-43901660

 skinmalignant_melanomaSubstitution - Missense

c.284G>T; p.G95V; 11:43889742-43889742

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.475C>T; p.R159C; 11:43901531-43901531

 stomachcarcinoma; adenocarcinomaSubstitution - Missense