lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	218
Symbol	ALDH3A1
Synonymous	ALDH3\|ALDHIII
Full name	aldehyde dehydrogenase 3 family, member A1
Gene description	aldehyde dehydrogenase isozyme 3\|aldehyde dehydrogenase type III\|aldehyde dehydrogenase, dimeric NADP-preferring\|stomach aldehyde dehydrogenase
Cytoband	17p11.2
Gene type	protein-coding
Synonymous	MIM:100660; HGNC:HGNC:405; Ensembl:ENSG00000108602; HPRD:00004; Vega:OTTHUMG00000059469

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.782T>G; p.V261G; 17:19741118-19741118	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.214G>T; p.E72*; 17:19743412-19743412	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.280C>T; p.Q94*; 17:19743346-19743346	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.16G>A; p.E6K; 17:19745114-19745114	urinary_tract; bladder	carcinoma	Substitution - Missense
c.616C>A; p.P206T; 17:19742077-19742077	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.13A>G; p.S5G; 17:19745117-19745117	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.16G>A; p.E6K; 17:19745114-19745114	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.711C>A; p.F237L; 17:19741189-19741189	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.809A>C; p.E270A; 17:19740476-19740476	pancreas	NS	Substitution - Missense
c.394G>T; p.G132W; 17:19743232-19743232	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1333C>T; p.P445S; 17:19738337-19738337	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.759C>T; p.D253D; 17:19741141-19741141	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.163-10G>C; p.?; 17:19743473-19743473	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1032C>T; p.C344C; 17:19739592-19739592	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.817G>A; p.G273R; 17:19740468-19740468	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1110C>T; p.N370N; 17:19739514-19739514	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1110C>T; p.N370N; 17:19739514-19739514	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1313G>A; p.G438D; 17:19738357-19738357	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1008C>A; p.F336L; 17:19739616-19739616	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.440C>T; p.A147V; 17:19742585-19742585	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.543C>T; p.F181F; 17:19742150-19742150	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.655G>A; p.V219M; 17:19742038-19742038	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.318C>T; p.G106G; 17:19743308-19743308	central_nervous_system; brain	glioma	Substitution - coding silent
c.335G>T; p.G112V; 17:19743291-19743291	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.604A>G; p.K202E; 17:19742089-19742089	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.550A>G; p.I184V; 17:19742143-19742143	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.328G>A; p.V110I; 17:19743298-19743298	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.969C>T; p.D323D; 17:19739655-19739655	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.569C>T; p.T190M; 17:19742124-19742124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.339C>T; p.T113T; 17:19743287-19743287	skin	malignant_melanoma	Substitution - coding silent
c.264G>T; p.E88D; 17:19743362-19743362	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.831delG; p.K278fs*17; 17:19740454-19740454	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.741T>A; p.P247P; 17:19741159-19741159	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116+1G>A; p.?; 17:19739507-19739507	skin	malignant_melanoma	Unknown
c.298A>C; p.I100L; 17:19743328-19743328	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.325C>T; p.L109F; 17:19743301-19743301	skin; acral	malignant_melanoma	Substitution - Missense
c.963C>T; p.L321L; 17:19739661-19739661	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.212T>C; p.I71T; 17:19743414-19743414	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.330C>A; p.V110V; 17:19743296-19743296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.950-3C>A; p.?; 17:19739677-19739677	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.189G>A; p.E63E; 17:19743437-19743437	thyroid	other; neoplasm	Substitution - coding silent
c.1317G>A; p.L439L; 17:19738353-19738353	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1258G>A; p.E420K; 17:19738412-19738412	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1258G>A; p.E420K; 17:19738412-19738412	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.924C>T; p.T308T; 17:19740361-19740361	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.288C>T; p.D96D; 17:19743338-19743338	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.288C>T; p.D96D; 17:19743338-19743338	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1297C>G; p.L433V; 17:19738373-19738373	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.985C>A; p.P329T; 17:19739639-19739639	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1168G>A; p.D390N; 17:19739044-19739044	skin	malignant_melanoma	Substitution - Missense
c.416C>T; p.P139L; 17:19742609-19742609	skin	malignant_melanoma	Substitution - Missense
c.1257C>T; p.F419F; 17:19738413-19738413	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1190T>C; p.L397S; 17:19739022-19739022	skin	malignant_melanoma	Substitution - Missense
c.815A>G; p.Y272C; 17:19740470-19740470	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1257C>T; p.F419F; 17:19738413-19738413	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1190T>C; p.L397S; 17:19739022-19739022	skin	malignant_melanoma	Substitution - Missense
c.1330C>T; p.P444S; 17:19738340-19738340	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.289G>A; p.E97K; 17:19743337-19743337	skin	malignant_melanoma	Substitution - Missense
c.697G>A; p.A233T; 17:19741203-19741203	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.697G>A; p.A233T; 17:19741203-19741203	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.392C>T; p.A131V; 17:19743234-19743234	skin	malignant_melanoma	Substitution - Missense
c.813C>A; p.F271L; 17:19740472-19740472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.816C>T; p.Y272Y; 17:19740469-19740469	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.816C>T; p.Y272Y; 17:19740469-19740469	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.531C>G; p.L177L; 17:19742162-19742162	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1347+1G>A; p.?; 17:19738322-19738322	central_nervous_system; brain	glioma	Unknown
c.356A>G; p.N119S; 17:19743270-19743270	skin	malignant_melanoma	Substitution - Missense
c.866G>A; p.R289Q; 17:19740419-19740419	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.623C>T; p.T208M; 17:19742070-19742070	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.935C>T; p.A312V; 17:19740350-19740350	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1334delC; p.P445fs*6; 17:19738336-19738336	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1334delC; p.P445fs*6; 17:19738336-19738336	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.691C>T; p.R231C; 17:19741209-19741209	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.692G>A; p.R231H; 17:19741208-19741208	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.836C>T; p.S279F; 17:19740449-19740449	skin	malignant_melanoma	Substitution - Missense
c.248C>T; p.A83V; 17:19743378-19743378	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.922A>C; p.T308P; 17:19740363-19740363	breast	carcinoma	Substitution - Missense
c.248C>T; p.A83V; 17:19743378-19743378	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.922A>C; p.T308P; 17:19740363-19740363	breast	carcinoma	Substitution - Missense
c.140C>G; p.A47G; 17:19744990-19744990	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.490C>T; p.P164S; 17:19742203-19742203	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.389C>T; p.A130V; 17:19743237-19743237	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.451G>A; p.A151T; 17:19742574-19742574	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1306G>A; p.D436N; 17:19738364-19738364	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1193A>T; p.H398L; 17:19739019-19739019	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1193A>T; p.H398L; 17:19739019-19739019	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.1193A>T; p.H398L; 17:19739019-19739019	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.941G>A; p.R314H; 17:19740344-19740344	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.818G>A; p.G273E; 17:19740467-19740467	skin	malignant_melanoma	Substitution - Missense
c.1009G>A; p.G337R; 17:19739615-19739615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.985C>G; p.P329A; 17:19739639-19739639	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.169T>C; p.W57R; 17:19743457-19743457	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1238A>G; p.Y413C; 17:19738432-19738432	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.97C>A; p.L33M; 17:19745033-19745033	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.681G>A; p.V227V; 17:19742012-19742012	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation