lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	214
Symbol	ALCAM
Synonymous	CD166\|MEMD
Full name	activated leukocyte cell adhesion molecule
Gene description	CD166 antigen
Cytoband	3q13.1
Gene type	protein-coding
Synonymous	MIM:601662; HGNC:HGNC:400; Ensembl:ENSG00000170017; HPRD:03389; Vega:OTTHUMG00000159192

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1362C>T; p.S454S; 3:105547511-105547511	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1362C>T; p.S454S; 3:105547511-105547511	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1567A>G; p.N523D; 3:105552488-105552488	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1236A>T; p.V412V; 3:105547280-105547280	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1610T>C; p.L537P; 3:105552531-105552531	skin	malignant_melanoma	Substitution - Missense
c.438C>A; p.L146L; 3:105532045-105532045	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.438C>A; p.L146L; 3:105532045-105532045	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1080G>A; p.R360R; 3:105545311-105545311	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.181C>T; p.P61S; 3:105524295-105524295	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.244G>A; p.D82N; 3:105524358-105524358	skin	malignant_melanoma	Substitution - Missense
c.1616C>T; p.A539V; 3:105552537-105552537	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1282G>A; p.G428R; 3:105547431-105547431	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.988C>A; p.H330N; 3:105541762-105541762	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.174T>G; p.Y58*; 3:105520167-105520167	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.952delA; p.S320fs*2; 3:105541726-105541726	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.952delA; p.S320fs*2; 3:105541726-105541726	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.952delA; p.S320fs*2; 3:105541726-105541726	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.952delA; p.S320fs*2; 3:105541726-105541726	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1038T>G; p.I346M; 3:105545269-105545269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.497G>A; p.G166D; 3:105533640-105533640	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.497G>A; p.G166D; 3:105533640-105533640	large_intestine; colon	carcinoma	Substitution - Missense
c.826C>T; p.P276S; 3:105540070-105540070	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.470G>A; p.C157Y; 3:105533613-105533613	thyroid	carcinoma	Substitution - Missense
c.1426T>G; p.S476A; 3:105550178-105550178	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1040G>T; p.G347V; 3:105545271-105545271	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.388G>T; p.V130L; 3:105524502-105524502	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1537G>C; p.E513Q; 3:105552173-105552173	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1209G>C; p.K403N; 3:105547253-105547253	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.536C>A; p.P179H; 3:105533679-105533679	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.941C>T; p.S314F; 3:105541715-105541715	skin	malignant_melanoma	Substitution - Missense
c.1241-1_1241GG>TT; p.?; 3:105547389-105547390	lung	carcinoma; adenocarcinoma	Unknown
c.1177G>A; p.E393K; 3:105547221-105547221	oesophagus	carcinoma	Substitution - Missense
c.1730A>G; p.N577S; 3:105571917-105571917	stomach	adenocarcinoma	Substitution - Missense
c.107G>A; p.G36E; 3:105520100-105520100	breast	carcinoma	Substitution - Missense
c.1260G>T; p.M420I; 3:105547409-105547409	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1602T>C; p.V534V; 3:105552523-105552523	breast	carcinoma; ductal_carcinoma	Substitution - coding silent
c.671A>G; p.Y224C; 3:105534786-105534786	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1602T>C; p.V534V; 3:105552523-105552523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.671A>G; p.Y224C; 3:105534786-105534786	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.671A>G; p.Y224C; 3:105534786-105534786	large_intestine; colon	carcinoma	Substitution - Missense
c.671A>G; p.Y224C; 3:105534786-105534786	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1211_1214delAAAG; p.R405fs*3; 3:105547255-105547258	breast	carcinoma	Deletion - Frameshift
c.992-1G>A; p.?; 3:105545222-105545222	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.488A>C; p.Y163S; 3:105533631-105533631	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.39C>A; p.F13L; 3:105367447-105367447	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1158T>C; p.D386D; 3:105547202-105547202	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1019G>T; p.G340V; 3:105545250-105545250	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.654C>T; p.F218F; 3:105534769-105534769	breast	carcinoma	Substitution - coding silent
c.130C>T; p.R44*; 3:105520123-105520123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.533A>G; p.H178R; 3:105533676-105533676	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1120C>T; p.R374*; 3:105547164-105547164	skin	malignant_melanoma	Substitution - Nonsense
c.1213_1214delAG; p.E406fs*19; 3:105547257-105547258	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.202A>G; p.I68V; 3:105524316-105524316	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1533A>C; p.A511A; 3:105552169-105552169	liver	carcinoma	Substitution - coding silent
c.1533A>C; p.A511A; 3:105552169-105552169	liver	carcinoma	Substitution - coding silent
c.959G>A; p.S320N; 3:105541733-105541733	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.438C>T; p.L146L; 3:105532045-105532045	skin	malignant_melanoma	Substitution - coding silent
c.81A>T; p.G27G; 3:105520074-105520074	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.81A>T; p.G27G; 3:105520074-105520074	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1379A>G; p.E460G; 3:105550131-105550131	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1379A>G; p.E460G; 3:105550131-105550131	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1323A>G; p.P441P; 3:105547472-105547472	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1379A>G; p.E460G; 3:105550131-105550131	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1379A>G; p.E460G; 3:105550131-105550131	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1705G>A; p.E569K; 3:105571892-105571892	skin	malignant_melanoma	Substitution - Missense
c.1281T>C; p.S427S; 3:105547430-105547430	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1150T>A; p.Y384N; 3:105547194-105547194	skin	malignant_melanoma	Substitution - Missense
c.1474G>A; p.E492K; 3:105550226-105550226	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.773A>G; p.N258S; 3:105540017-105540017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.712G>A; p.A238T; 3:105534827-105534827	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1090G>A; p.V364M; 3:105545321-105545321	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.550G>T; p.V184L; 3:105534665-105534665	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1528G>A; p.E510K; 3:105552164-105552164	breast	carcinoma	Substitution - Missense
c.649C>A; p.P217T; 3:105534764-105534764	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1056G>A; p.V352V; 3:105545287-105545287	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1728A>C; p.E576D; 3:105571915-105571915	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.453delA; p.K153fs*34; 3:105532060-105532060	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.322G>T; p.E108*; 3:105524436-105524436	breast	carcinoma	Substitution - Nonsense
c.453delA; p.K153fs*34; 3:105532060-105532060	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1216G>A; p.E406K; 3:105547260-105547260	skin	malignant_melanoma	Substitution - Missense
c.1314A>C; p.E438D; 3:105547463-105547463	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1462G>A; p.E488K; 3:105550214-105550214	urinary_tract; bladder	carcinoma	Substitution - Missense
c.902C>T; p.T301M; 3:105541676-105541676	thyroid	other; neoplasm	Substitution - Missense
c.1348A>G; p.T450A; 3:105547497-105547497	pancreas	carcinoma	Substitution - Missense
c.131G>A; p.R44Q; 3:105520124-105520124	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1659G>A; p.K553K; 3:105552580-105552580	skin	malignant_melanoma	Substitution - coding silent
c.535C>T; p.P179S; 3:105533678-105533678	skin	malignant_melanoma	Substitution - Missense
c.1378G>C; p.E460Q; 3:105550130-105550130	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1370A>G; p.N457S; 3:105547519-105547519	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.838G>A; p.E280K; 3:105540082-105540082	skin; extremity	malignant_melanoma	Substitution - Missense
c.453A>G; p.L151L; 3:105532060-105532060	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.129C>T; p.C43C; 3:105520122-105520122	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1100T>C; p.M367T; 3:105545331-105545331	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.900G>A; p.L300L; 3:105541674-105541674	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.16G>C; p.A6P; 3:105367424-105367424	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.498C>T; p.G166G; 3:105533641-105533641	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.530T>A; p.L177Q; 3:105533673-105533673	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.959G>C; p.S320T; 3:105541733-105541733	breast	carcinoma	Substitution - Missense
c.459G>T; p.K153N; 3:105532066-105532066	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1193A>G; p.E398G; 3:105547237-105547237	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1378G>T; p.E460*; 3:105550130-105550130	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1387C>T; p.P463S; 3:105550139-105550139	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.212G>C; p.R71T; 3:105524326-105524326	pancreas	carcinoma	Substitution - Missense
c.463G>T; p.G155C; 3:105533606-105533606	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1035G>C; p.Q345H; 3:105545266-105545266	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1395T>G; p.I465M; 3:105550147-105550147	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1035G>C; p.Q345H; 3:105545266-105545266	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.534T>G; p.H178Q; 3:105533677-105533677	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.829delC; p.P278fs*15; 3:105540073-105540073	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.367G>A; p.E123K; 3:105524481-105524481	urinary_tract; bladder	carcinoma	Substitution - Missense
c.205G>A; p.A69T; 3:105524319-105524319	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.115A>G; p.I39V; 3:105520108-105520108	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.329G>A; p.R110K; 3:105524443-105524443	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1409A>G; p.Y470C; 3:105550161-105550161	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.837G>A; p.E279E; 3:105540081-105540081	skin	malignant_melanoma	Substitution - coding silent
c.1299A>G; p.I433M; 3:105547448-105547448	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.327G>C; p.K109N; 3:105524441-105524441	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1601T>C; p.V534A; 3:105552522-105552522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.673T>C; p.Y225H; 3:105534788-105534788	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.536C>T; p.P179L; 3:105533679-105533679	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1661C>T; p.S554L; 3:105552582-105552582	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.458A>T; p.K153M; 3:105532065-105532065	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1281T>G; p.S427R; 3:105547430-105547430	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.531A>G; p.L177L; 3:105533674-105533674	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.790G>C; p.D264H; 3:105540034-105540034	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1600_1601insT; p.G535fs*33; 3:105552521-105552522	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.903G>A; p.T301T; 3:105541677-105541677	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.909G>A; p.V303V; 3:105541683-105541683	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.998A>T; p.D333V; 3:105545229-105545229	skin	malignant_melanoma	Substitution - Missense
c.409_410CC>TT; p.P137F; 3:105532016-105532017	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.633G>T; p.K211N; 3:105534748-105534748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.609C>A; p.S203S; 3:105534724-105534724	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1746A>G; p.E582E; 3:105571933-105571933	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.768delA; p.N258fs*14; 3:105540012-105540012	pancreas	carcinoma; acinar_carcinoma	Deletion - Frameshift
c.1723G>C; p.E575Q; 3:105571910-105571910	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.323A>C; p.E108A; 3:105524437-105524437	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation