lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2026
Symbol	ENO2
Synonymous	HEL-S-279\|NSE
Full name	enolase 2 (gamma, neuronal)
Gene description	2-phospho-D-glycerate hydro-lyase\|2-phospho-D-glycerate hydrolyase\|epididymis secretory protein Li 279\|gamma-enolase\|neural enolase\|neuron specific gamma enolase\|neuron-specific enolase\|neurone-specific enolase
Cytoband	12p13
Gene type	protein-coding
Synonymous	MIM:131360; HGNC:HGNC:3353; Ensembl:ENSG00000111674; HPRD:00573; Vega:OTTHUMG00000168967

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.544A>C; p.M182L; 12:6918039-6918039	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.263A>T; p.E88V; 12:6917060-6917060	skin	malignant_melanoma	Substitution - Missense
c.384G>T; p.L128L; 12:6917654-6917654	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.979C>A; p.R327S; 12:6921694-6921694	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.913T>C; p.S305P; 12:6921628-6921628	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.997G>A; p.E333K; 12:6921712-6921712	skin	malignant_melanoma	Substitution - Missense
c.668_669CC>TT; p.A223V; 12:6919566-6919567	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.989G>A; p.R330Q; 12:6921704-6921704	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.385C>G; p.P129A; 12:6917655-6917655	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1159G>T; p.G387W; 12:6922147-6922147	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.385C>G; p.P129A; 12:6917655-6917655	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1173C>G; p.G391G; 12:6922161-6922161	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1173C>G; p.G391G; 12:6922161-6922161	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1173C>G; p.G391G; 12:6922161-6922161	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1173C>G; p.G391G; 12:6922161-6922161	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1173C>G; p.G391G; 12:6922161-6922161	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1173C>G; p.G391G; 12:6922161-6922161	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1069T>G; p.C357G; 12:6922057-6922057	breast	carcinoma	Substitution - Missense
c.1179C>G; p.I393M; 12:6922346-6922346	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1179C>G; p.I393M; 12:6922346-6922346	urinary_tract; bladder	carcinoma	Substitution - Missense
c.221C>T; p.A74V; 12:6916710-6916710	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.221C>T; p.A74V; 12:6916710-6916710	skin	malignant_melanoma	Substitution - Missense
c.181G>A; p.G61S; 12:6916512-6916512	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1047G>C; p.S349S; 12:6921762-6921762	thyroid	other; neoplasm	Substitution - coding silent
c.720C>T; p.I240I; 12:6919618-6919618	ovary	other; neoplasm	Substitution - coding silent
c.720C>T; p.I240I; 12:6919618-6919618	ovary	other; neoplasm	Substitution - coding silent
c.1173C>A; p.G391G; 12:6922161-6922161	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.21G>A; p.W7*; 12:6915853-6915853	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.21G>A; p.W7*; 12:6915853-6915853	liver	carcinoma	Substitution - Nonsense
c.21G>A; p.W7*; 12:6915853-6915853	liver	carcinoma	Substitution - Nonsense
c.3G>A; p.M1I; 12:6915835-6915835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.833C>T; p.A278V; 12:6919731-6919731	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1007C>T; p.A336V; 12:6921722-6921722	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1193delC; p.P398fs*14; 12:6922360-6922360	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Deletion - Frameshift
c.1145C>T; p.A382V; 12:6922133-6922133	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.865+1G>A; p.?; 12:6919764-6919764	liver	carcinoma	Unknown
c.865+1G>A; p.?; 12:6919764-6919764	liver	carcinoma	Unknown
c.5C>T; p.S2F; 12:6915837-6915837	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.758G>A; p.R253H; 12:6919656-6919656	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1134C>A; p.D378E; 12:6922122-6922122	thyroid	other; neoplasm	Substitution - Missense
c.547C>T; p.R183*; 12:6918042-6918042	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.129C>T; p.I43I; 12:6916460-6916460	kidney	other; neoplasm	Substitution - coding silent
c.559G>C; p.E187Q; 12:6918054-6918054	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.13A>C; p.K5Q; 12:6915845-6915845	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.692T>C; p.I231T; 12:6919590-6919590	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.692T>C; p.I231T; 12:6919590-6919590	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1161G>A; p.G387G; 12:6922149-6922149	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.236G>A; p.S79N; 12:6916725-6916725	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.841C>T; p.Q281*; 12:6919739-6919739	skin	malignant_melanoma	Substitution - Nonsense
c.95G>A; p.R32Q; 12:6916426-6916426	oesophagus	carcinoma	Substitution - Missense
c.72C>G; p.L24L; 12:6915904-6915904	pancreas	carcinoma	Substitution - coding silent
c.1042G>A; p.G348S; 12:6921757-6921757	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.543C>A; p.A181A; 12:6918038-6918038	thyroid	other; neoplasm	Substitution - coding silent
c.1195T>C; p.C399R; 12:6922362-6922362	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.769T>C; p.Y257H; 12:6919667-6919667	urinary_tract; bladder	carcinoma	Substitution - Missense
c.769T>C; p.Y257H; 12:6919667-6919667	urinary_tract; bladder	carcinoma	Substitution - Missense
c.769T>C; p.Y257H; 12:6919667-6919667	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.333C>T; p.I111I; 12:6917603-6917603	skin	malignant_melanoma	Substitution - coding silent
c.443C>T; p.P148L; 12:6917713-6917713	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.432C>T; p.I144I; 12:6917702-6917702	skin; arm	malignant_melanoma	Substitution - coding silent
c.123G>T; p.T41T; 12:6916454-6916454	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.196G>A; p.V66M; 12:6916685-6916685	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.911G>T; p.W304L; 12:6921626-6921626	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.173T>C; p.L58S; 12:6916504-6916504	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.176G>A; p.G59D; 12:6916507-6916507	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation