lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2023
Symbol	ENO1
Synonymous	ENO1L1\|MPB1\|NNE\|PPH
Full name	enolase 1, (alpha)
Gene description	2-phospho-D-glycerate hydro-lyase\|MYC promoter-binding protein 1\|alpha enolase like 1\|alpha-enolase\|enolase-alpha\|non-neural enolase\|phosphopyruvate hydratase\|plasminogen-binding protein\|tau-crystallin
Cytoband	1p36.2
Gene type	protein-coding
Synonymous	MIM:172430; HGNC:HGNC:3350; Ensembl:ENSG00000074800; HPRD:01400; Vega:OTTHUMG00000001773

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.323C>T; p.A108V; 1:8867238-8867238	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1202C>T; p.S401F; 1:8862920-8862920	skin	malignant_melanoma	Substitution - Missense
c.1192C>G; p.P398A; 1:8862930-8862930	skin	malignant_melanoma	Substitution - Missense
c.622G>T; p.G208W; 1:8866324-8866324	thyroid	other; neoplasm	Substitution - Missense
c.726C>T; p.I242I; 1:8865424-8865424	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.534C>T; p.F178F; 1:8866412-8866412	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.547C>T; p.R183C; 1:8866399-8866399	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.735C>T; p.D245D; 1:8865415-8865415	prostate	adenoma	Substitution - coding silent
c.1192C>T; p.P398S; 1:8862930-8862930	skin	malignant_melanoma	Substitution - Missense
c.1305A>G; p.435; 1:8861360-8861360	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.719T>C; p.V240A; 1:8865431-8865431	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.383T>C; p.V128A; 1:8867178-8867178	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1086_1096del11; p.N363fs*11; 1:8863315-8863325	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.972C>T; p.N324N; 1:8863986-8863986	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.402C>T; p.I134I; 1:8867159-8867159	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.155A>G; p.N52S; 1:8871917-8871917	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.285C>T; p.I95I; 1:8868013-8868013	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.285C>T; p.I95I; 1:8868013-8868013	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.7A>G; p.I3V; 1:8874902-8874902	urinary_tract; bladder	carcinoma	Substitution - Missense
c.869T>G; p.V290G; 1:8864089-8864089	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.793G>T; p.D265Y; 1:8865357-8865357	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1007C>T; p.S336F; 1:8863951-8863951	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1273G>A; p.G425S; 1:8861392-8861392	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.241-9C>A; p.?; 1:8868066-8868066	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.548G>A; p.R183H; 1:8866398-8866398	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1177-2A>G; p.?; 1:8862947-8862947	prostate	carcinoma; adenocarcinoma	Unknown
c.221C>T; p.A74V; 1:8870471-8870471	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.387C>A; p.P129P; 1:8867174-8867174	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.363T>A; p.A121A; 1:8867198-8867198	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.927C>T; p.A309A; 1:8864031-8864031	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.308A>C; p.K103T; 1:8867990-8867990	breast	carcinoma	Substitution - Missense
c.1299C>A; p.A433A; 1:8861366-8861366	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.419A>G; p.N140S; 1:8867142-8867142	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.446C>T; p.A149V; 1:8866500-8866500	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>A; p.V240M; 1:8865432-8865432	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.59T>G; p.V20G; 1:8874850-8874850	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.59T>G; p.V20G; 1:8874850-8874850	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.324G>A; p.A108A; 1:8867237-8867237	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1152G>A; p.L384L; 1:8863259-8863259	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.634G>A; p.G212R; 1:8866312-8866312	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.976A>C; p.K326Q; 1:8863982-8863982	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.392A>C; p.Y131S; 1:8867169-8867169	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.768G>T; p.K256N; 1:8865382-8865382	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.652C>A; p.L218M; 1:8866294-8866294	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.998A>G; p.N333S; 1:8863960-8863960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.337G>T; p.G113W; 1:8867224-8867224	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.250G>A; p.V84I; 1:8868048-8868048	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1018C>T; p.L340F; 1:8863940-8863940	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.249C>T; p.N83N; 1:8868049-8868049	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.249C>T; p.N83N; 1:8868049-8868049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.687T>C; p.T229T; 1:8865463-8865463	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.479G>A; p.G160D; 1:8866467-8866467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.315G>A; p.K105K; 1:8867246-8867246	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1197C>T; p.C399C; 1:8862925-8862925	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.854delA; p.K285fs*31; 1:8865296-8865296	skin	malignant_melanoma	Deletion - Frameshift
c.761C>T; p.S254F; 1:8865389-8865389	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.621G>C; p.V207V; 1:8866325-8866325	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.72C>G; p.L24L; 1:8874837-8874837	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.86-1G>C; p.?; 1:8871987-8871987	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Unknown
c.326A>G; p.N109S; 1:8867235-8867235	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.999C>T; p.N333N; 1:8863959-8863959	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.999C>T; p.N333N; 1:8863959-8863959	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.611C>T; p.A204V; 1:8866335-8866335	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.147C>T; p.L49L; 1:8871925-8871925	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1272C>A; p.A424A; 1:8861393-8861393	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011C>T; p.C337C; 1:8863947-8863947	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.148C>T; p.R50W; 1:8871924-8871924	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.572A>G; p.N191S; 1:8866374-8866374	pancreas	carcinoma	Substitution - Missense
c.24C>T; p.A8A; 1:8874885-8874885	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.573_574CC>TT; p.(=); 1:8866372-8866373	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1064A>G; p.Q355R; 1:8863894-8863894	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation