lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2018
Symbol	EMX2
Synonymous	-
Full name	empty spiracles homeobox 2
Gene description	empty spiracles homolog 2\|empty spiracles-like protein 2\|homeobox protein EMX2
Cytoband	10q26.1
Gene type	protein-coding
Synonymous	MIM:600035; HGNC:HGNC:3341; Ensembl:ENSG00000170370; HPRD:02495; Vega:OTTHUMG00000019123

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.504G>A; p.R168R; 10:117545729-117545729	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.583G>A; p.E195K; 10:117545808-117545808	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.213C>A; p.F71L; 10:117543480-117543480	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.570_571CC>AA; p.S190_L191>RI; 10:117545795-117545796	lung	carcinoma; adenocarcinoma	Complex - compound substitution
c.617G>A; p.R206K; 10:117548090-117548090	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.239A>C; p.N80T; 10:117543506-117543506	thyroid	other; neoplasm	Substitution - Missense
c.239A>C; p.N80T; 10:117543506-117543506	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.444_445delCG; p.L150fs*24; 10:117545669-117545670	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.352A>C; p.T118P; 10:117543619-117543619	prostate	carcinoma	Substitution - Missense
c.478G>A; p.A160T; 10:117545703-117545703	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.478G>A; p.A160T; 10:117545703-117545703	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.270G>A; p.P90P; 10:117543537-117543537	ovary	other; neoplasm	Substitution - coding silent
c.160_162delGCC; p.A59delA; 10:117543427-117543429	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.160_162delGCC; p.A59delA; 10:117543427-117543429	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - In frame
c.467G>A; p.R156Q; 10:117545692-117545692	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.76C>T; p.R26C; 10:117543343-117543343	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.176C>T; p.A59V; 10:117543443-117543443	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.623A>C; p.K208T; 10:117548096-117548096	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.332C>A; p.S111*; 10:117543599-117543599	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.508G>A; p.E170K; 10:117545733-117545733	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.743T>C; p.V248A; 10:117548216-117548216	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.473G>A; p.R158Q; 10:117545698-117545698	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.426G>T; p.E142D; 10:117545651-117545651	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.663G>A; p.S221S; 10:117548136-117548136	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.663G>A; p.S221S; 10:117548136-117548136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.332C>T; p.S111L; 10:117543599-117543599	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.332C>T; p.S111L; 10:117543599-117543599	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.332C>T; p.S111L; 10:117543599-117543599	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.366G>A; p.W122*; 10:117543633-117543633	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.6C>T; p.F2F; 10:117543273-117543273	pancreas	carcinoma	Substitution - coding silent
c.707T>A; p.I236N; 10:117548180-117548180	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.694A>C; p.N232H; 10:117548167-117548167	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.87C>T; p.D29D; 10:117543354-117543354	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.644A>G; p.E215G; 10:117548117-117548117	breast	carcinoma	Substitution - Missense
c.547G>A; p.E183K; 10:117545772-117545772	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.684G>A; p.T228T; 10:117548157-117548157	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.371T>A; p.I124N; 10:117543638-117543638	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.371T>A; p.I124N; 10:117543638-117543638	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.652G>C; p.G218R; 10:117548125-117548125	skin	malignant_melanoma	Substitution - Missense
c.302C>T; p.S101F; 10:117543569-117543569	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.302C>T; p.S101F; 10:117543569-117543569	urinary_tract; bladder	carcinoma	Substitution - Missense
c.446C>A; p.A149E; 10:117545671-117545671	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.647A>G; p.E216G; 10:117548120-117548120	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.273G>A; p.P91P; 10:117543540-117543540	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.698G>A; p.R233Q; 10:117548171-117548171	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.722C>T; p.A241V; 10:117548195-117548195	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.202G>T; p.D68Y; 10:117543469-117543469	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.143T>G; p.L48R; 10:117543410-117543410	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.592G>T; p.V198L; 10:117548065-117548065	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.228G>A; p.S76S; 10:117543495-117543495	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.228G>A; p.S76S; 10:117543495-117543495	pancreas	carcinoma	Substitution - coding silent
c.683C>T; p.T228M; 10:117548156-117548156	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.727C>T; p.P243S; 10:117548200-117548200	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.312G>A; p.S104S; 10:117543579-117543579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.455G>A; p.R152Q; 10:117545680-117545680	prostate	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation