lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2011
Symbol	MARK2
Synonymous	EMK-1\|EMK1\|PAR-1\|Par-1b\|Par1b
Full name	MAP/microtubule affinity-regulating kinase 2
Gene description	ELKL motif kinase 1\|PAR1 homolog b\|Ser/Thr protein kinase PAR-1B\|serine/threonine protein kinase EMK\|serine/threonine-protein kinase MARK2
Cytoband	11q13.1
Gene type	protein-coding
Synonymous	MIM:600526; HGNC:HGNC:3332; Ensembl:ENSG00000072518; HPRD:02753

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1730T>A; p.L577*; 11:63904941-63904941	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.217G>C; p.V73L; 11:63898259-63898259	breast	carcinoma	Substitution - Missense
c.883C>T; p.R295W; 11:63900873-63900873	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.285C>A; p.V95V; 11:63898654-63898654	skin	malignant_melanoma	Substitution - coding silent
c.490A>G; p.S164G; 11:63899931-63899931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1991C>G; p.P664R; 11:63908990-63908990	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.548C>A; p.A183D; 11:63899989-63899989	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.826G>A; p.E276K; 11:63900816-63900816	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.826G>A; p.E276K; 11:63900816-63900816	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2014C>T; p.R672C; 11:63909013-63909013	skin	malignant_melanoma	Substitution - Missense
c.881G>A; p.R294Q; 11:63900871-63900871	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.881G>A; p.R294Q; 11:63900871-63900871	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.829G>A; p.D277N; 11:63900819-63900819	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.242A>C; p.K81T; 11:63898611-63898611	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2224G>A; p.E742K; 11:63909223-63909223	skin	malignant_melanoma	Substitution - Missense
c.331C>A; p.H111N; 11:63898789-63898789	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1714C>T; p.R572W; 11:63904925-63904925	central_nervous_system; brain	glioma	Substitution - Missense
c.1714C>T; p.R572W; 11:63904925-63904925	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1305_1306CC>TT; p.P436S; 11:63902773-63902774	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1305_1306CC>TT; p.P436S; 11:63902773-63902774	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.571delA; p.K192fs*12; 11:63900012-63900012	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.37G>A; p.E13K; 11:63895240-63895240	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.714C>A; p.F238L; 11:63900603-63900603	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1354_1355insC; p.L454fs*65; 11:63903100-63903101	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1010G>A; p.G337D; 11:63902205-63902205	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1999A>T; p.M667L; 11:63908998-63908998	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.7C>T; p.R3W; 11:63895210-63895210	skin	malignant_melanoma	Substitution - Missense
c.7C>T; p.R3W; 11:63895210-63895210	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1995C>A; p.N665K; 11:63908994-63908994	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1642C>T; p.P548S; 11:63904853-63904853	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1210G>C; p.E404Q; 11:63902678-63902678	breast	carcinoma	Substitution - Missense
c.390G>A; p.V130V; 11:63899066-63899066	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1A>G; p.M1V; 11:63895204-63895204	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1063G>T; p.A355S; 11:63902258-63902258	skin	malignant_melanoma	Substitution - Missense
c.574A>G; p.K192E; 11:63900015-63900015	liver	carcinoma	Substitution - Missense
c.1820A>G; p.K607R; 11:63905031-63905031	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.924G>T; p.E308D; 11:63900991-63900991	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.890-1G>A; p.?; 11:63900956-63900956	urinary_tract; bladder	carcinoma	Unknown
c.437delA; p.N147fs*8; 11:63899878-63899878	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1519A>T; p.N507Y; 11:63904092-63904092	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.346G>C; p.E116Q; 11:63898804-63898804	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.346G>C; p.E116Q; 11:63898804-63898804	urinary_tract; bladder	carcinoma	Substitution - Missense
c.75C>A; p.T25T; 11:63895278-63895278	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.423A>C; p.R141S; 11:63899099-63899099	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1994A>G; p.N665S; 11:63908993-63908993	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1537delC; p.T515fs*67; 11:63904110-63904110	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2142G>A; p.R714R; 11:63909141-63909141	liver	carcinoma	Substitution - coding silent
c.2142G>A; p.R714R; 11:63909141-63909141	liver	carcinoma	Substitution - coding silent
c.1431C>G; p.S477S; 11:63904004-63904004	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1121G>A; p.R374H; 11:63902316-63902316	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.677G>T; p.R226L; 11:63900566-63900566	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1205G>A; p.R402Q; 11:63902673-63902673	breast	carcinoma	Substitution - Missense
c.1535T>G; p.L512R; 11:63904108-63904108	skin	malignant_melanoma	Substitution - Missense
c.690G>A; p.L230L; 11:63900579-63900579	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.645G>C; p.L215L; 11:63900086-63900086	skin; leg	malignant_melanoma; nodular	Substitution - coding silent
c.1192G>A; p.A398T; 11:63902660-63902660	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1847C>A; p.P616H; 11:63908274-63908274	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.982C>A; p.L328M; 11:63901049-63901049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.982C>A; p.L328M; 11:63901049-63901049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2107G>A; p.V703M; 11:63909106-63909106	stomach	adenocarcinoma	Substitution - Missense
c.1427G>T; p.G476V; 11:63904000-63904000	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.501C>T; p.F167F; 11:63899942-63899942	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2107G>A; p.V703M; 11:63909106-63909106	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2107G>A; p.V703M; 11:63909106-63909106	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1028A>C; p.K343T; 11:63902223-63902223	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.677G>C; p.R226P; 11:63900566-63900566	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.789+1G>T; p.?; 11:63900679-63900679	lung	carcinoma; small_cell_carcinoma	Unknown
c.1087C>T; p.Q363*; 11:63902282-63902282	breast	carcinoma	Substitution - Nonsense
c.395A>G; p.Y132C; 11:63899071-63899071	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2015G>A; p.R672H; 11:63909014-63909014	prostate	carcinoma	Substitution - Missense
c.290A>T; p.E97V; 11:63898659-63898659	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2147C>T; p.S716F; 11:63909146-63909146	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.805C>T; p.R269*; 11:63900795-63900795	pancreas	carcinoma; acinar_carcinoma	Substitution - Nonsense
c.805C>T; p.R269*; 11:63900795-63900795	skin	malignant_melanoma	Substitution - Nonsense
c.432G>T; p.K144N; 11:63899108-63899108	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.432+1G>C; p.?; 11:63899109-63899109	pancreas	carcinoma	Unknown
c.189+2T>A; p.?; 11:63895635-63895635	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.884G>A; p.R295Q; 11:63900874-63900874	thyroid	carcinoma	Substitution - Missense
c.456T>C; p.A152A; 11:63899897-63899897	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.222G>A; p.L74L; 11:63898264-63898264	prostate	adenoma	Substitution - coding silent
c.990C>G; p.Y330*; 11:63901057-63901057	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.990C>G; p.Y330*; 11:63901057-63901057	pancreas	carcinoma	Substitution - Nonsense
c.2094C>T; p.G698G; 11:63909093-63909093	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1425A>T; p.P475P; 11:63903998-63903998	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1233G>T; p.R411R; 11:63902701-63902701	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2001G>A; p.M667I; 11:63909000-63909000	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2151C>T; p.L717L; 11:63909150-63909150	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.359G>A; p.R120Q; 11:63898817-63898817	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2151C>T; p.L717L; 11:63909150-63909150	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1678C>T; p.R560*; 11:63904889-63904889	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1268C>T; p.P423L; 11:63902736-63902736	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.356C>T; p.A119V; 11:63898814-63898814	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.670G>C; p.E224Q; 11:63900559-63900559	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1469C>T; p.A490V; 11:63904042-63904042	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.670G>C; p.E224Q; 11:63900559-63900559	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1439C>A; p.S480Y; 11:63904012-63904012	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.700T>C; p.Y234H; 11:63900589-63900589	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2000T>G; p.M667R; 11:63908999-63908999	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.289G>A; p.E97K; 11:63898658-63898658	urinary_tract; bladder	carcinoma	Substitution - Missense
c.197G>A; p.R66H; 11:63898239-63898239	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1545G>T; p.T515T; 11:63904118-63904118	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2129G>A; p.C710Y; 11:63909128-63909128	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.303_304insG; p.E103fs*4; 11:63898672-63898673	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Insertion - Frameshift
c.1757C>T; p.P586L; 11:63904968-63904968	skin	malignant_melanoma	Substitution - Missense
c.171C>A; p.N57K; 11:63895615-63895615	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.770G>A; p.S257N; 11:63900659-63900659	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.171C>A; p.N57K; 11:63895615-63895615	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.491G>A; p.S164N; 11:63899932-63899932	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.491G>A; p.S164N; 11:63899932-63899932	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.412A>G; p.I138V; 11:63899088-63899088	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1943G>A; p.R648H; 11:63908942-63908942	liver	carcinoma	Substitution - Missense
c.1943G>A; p.R648H; 11:63908942-63908942	liver	carcinoma	Substitution - Missense
c.289G>T; p.E97*; 11:63898658-63898658	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.51T>A; p.I17I; 11:63895254-63895254	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1689C>T; p.F563F; 11:63904900-63904900	skin	malignant_melanoma	Substitution - coding silent
c.1997A>G; p.E666G; 11:63908996-63908996	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.725C>T; p.T242M; 11:63900614-63900614	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.975T>C; p.Y325Y; 11:63901042-63901042	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1357C>T; p.P453S; 11:63903103-63903103	skin	malignant_melanoma	Substitution - Missense
c.435A>G; p.A145A; 11:63899876-63899876	central_nervous_system; brain	glioma	Substitution - coding silent
c.85G>A; p.G29S; 11:63895288-63895288	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.593T>G; p.V198G; 11:63900034-63900034	breast	carcinoma	Substitution - Missense
c.2177C>T; p.S726L; 11:63909176-63909176	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1063G>A; p.A355T; 11:63902258-63902258	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.637G>A; p.G213R; 11:63900078-63900078	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1992C>G; p.P664P; 11:63908991-63908991	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.878C>T; p.P293L; 11:63900868-63900868	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2102A>G; p.D701G; 11:63909101-63909101	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.518T>C; p.L173P; 11:63899959-63899959	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>A; p.D199N; 11:63900036-63900036	skin	malignant_melanoma	Substitution - Missense
c.2091G>A; p.P697P; 11:63909090-63909090	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1612G>A; p.A538T; 11:63904823-63904823	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1587G>A; p.Q529Q; 11:63904798-63904798	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.902C>T; p.S301F; 11:63900969-63900969	NS	malignant_melanoma	Substitution - Missense
c.1661C>T; p.P554L; 11:63904872-63904872	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.902C>T; p.S301F; 11:63900969-63900969	pancreas	carcinoma	Substitution - Missense
c.1993A>G; p.N665D; 11:63908992-63908992	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.736A>T; p.N246Y; 11:63900625-63900625	liver	carcinoma	Substitution - Missense
c.736A>T; p.N246Y; 11:63900625-63900625	liver	carcinoma	Substitution - Missense
c.370C>T; p.R124C; 11:63898828-63898828	skin	malignant_melanoma	Substitution - Missense
c.1181_1182delAG; p.S395fs*1; 11:63902649-63902650	breast	carcinoma	Deletion - Frameshift
c.211A>G; p.M71V; 11:63898253-63898253	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.109G>A; p.A37T; 11:63895312-63895312	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1606C>A; p.P536T; 11:63904817-63904817	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.538C>T; p.P180S; 11:63899979-63899979	pancreas	carcinoma	Substitution - Missense
c.2002A>G; p.M668V; 11:63909001-63909001	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.539C>T; p.P180L; 11:63899980-63899980	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1921G>A; p.E641K; 11:63908920-63908920	oesophagus	carcinoma	Substitution - Missense
c.480C>A; p.D160E; 11:63899921-63899921	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.480C>A; p.D160E; 11:63899921-63899921	pancreas	carcinoma	Substitution - Missense
c.1369C>T; p.R457W; 11:63903115-63903115	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1091G>A; p.R364H; 11:63902286-63902286	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1679G>A; p.R560Q; 11:63904890-63904890	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1921G>C; p.E641Q; 11:63908920-63908920	breast	carcinoma	Substitution - Missense
c.922G>T; p.E308*; 11:63900989-63900989	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1861C>T; p.R621*; 11:63908288-63908288	skin	malignant_melanoma	Substitution - Nonsense
c.238G>T; p.V80F; 11:63898280-63898280	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1594C>T; p.P532S; 11:63904805-63904805	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1605C>T; p.S535S; 11:63904816-63904816	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.844delC; p.P282fs*17; 11:63900834-63900834	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1217A>G; p.D406G; 11:63902685-63902685	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1217A>G; p.D406G; 11:63902685-63902685	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.150C>T; p.I50I; 11:63895594-63895594	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1740T>C; p.G580G; 11:63904951-63904951	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1737C>T; p.Y579Y; 11:63904948-63904948	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2046C>T; p.S682S; 11:63909045-63909045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.502A>C; p.T168P; 11:63899943-63899943	breast	carcinoma	Substitution - Missense
c.1101G>A; p.S367S; 11:63902296-63902296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.703C>T; p.R235C; 11:63900592-63900592	central_nervous_system; brain	glioma	Substitution - Missense
c.569G>A; p.G190D; 11:63900010-63900010	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.679G>T; p.E227*; 11:63900568-63900568	pancreas	carcinoma	Substitution - Nonsense
c.1568G>A; p.R523Q; 11:63904141-63904141	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation