lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1978
Symbol	EIF4EBP1
Synonymous	4E-BP1\|4EBP1\|BP-1\|PHAS-I
Full name	eukaryotic translation initiation factor 4E binding protein 1
Gene description	eIF4E-binding protein 1\|eukaryotic translation initiation factor 4E-binding protein 1\|phosphorylated heat- and acid-stable protein regulated by insulin 1
Cytoband	8p12
Gene type	protein-coding
Synonymous	MIM:602223; HGNC:HGNC:3288; Ensembl:ENSG00000187840; HPRD:03746; Vega:OTTHUMG00000164012

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.156C>T; p.I52I; 8:38057091-38057091	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.321G>T; p.A107A; 8:38057256-38057256	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.176T>A; p.L59Q; 8:38057111-38057111	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.319G>A; p.A107T; 8:38057254-38057254	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.219G>A; p.R73R; 8:38057154-38057154	skin	malignant_melanoma	Substitution - coding silent
c.187C>T; p.R63W; 8:38057122-38057122	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.257G>A; p.S86N; 8:38057192-38057192	urinary_tract; bladder	carcinoma	Substitution - Missense
c.320C>T; p.A107V; 8:38057255-38057255	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.320C>T; p.A107V; 8:38057255-38057255	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.166C>T; p.R56W; 8:38057101-38057101	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.291C>A; p.H97Q; 8:38057226-38057226	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.48C>T; p.P16P; 8:38030621-38030621	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.322G>T; p.G108C; 8:38057257-38057257	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.180G>T; p.M60I; 8:38057115-38057115	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.201G>T; p.V67V; 8:38057136-38057136	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.167G>A; p.R56Q; 8:38057102-38057102	skin	malignant_melanoma	Substitution - Missense