lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1857
Symbol	DVL3
Synonymous	-
Full name	dishevelled segment polarity protein 3
Gene description	DSH homolog 3\|dishevelled 3 (homologous to Drosophila dsh)\|dishevelled, dsh homolog 3\|dishevelled-3\|segment polarity protein dishevelled homolog DVL-3
Cytoband	3q27
Gene type	protein-coding
Synonymous	MIM:601368; HGNC:HGNC:3087; Ensembl:ENSG00000161202; HPRD:03222; Vega:OTTHUMG00000156841

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1581G>A; p.P527P; 3:184170088-184170088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1591C>T; p.P531S; 3:184170098-184170098	skin	malignant_melanoma	Substitution - Missense
c.647G>C; p.R216T; 3:184165160-184165160	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.653A>G; p.K218R; 3:184165166-184165166	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.443G>A; p.R148Q; 3:184164581-184164581	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.817G>T; p.D273Y; 3:184166179-184166179	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1154C>A; p.T385N; 3:184166931-184166931	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.625A>T; p.S209C; 3:184165138-184165138	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1280A>G; p.E427G; 3:184167661-184167661	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.991C>A; p.L331M; 3:184166616-184166616	oesophagus	carcinoma	Substitution - Missense
c.988A>G; p.T330A; 3:184166613-184166613	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.232-7C>A; p.?; 3:184164260-184164260	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.281A>T; p.D94V; 3:184164316-184164316	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1385_1386GG>TT; p.R462I; 3:184167952-184167953	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.369G>T; p.G123G; 3:184164507-184164507	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1555G>A; p.D519N; 3:184170062-184170062	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1744G>A; p.G582S; 3:184170348-184170348	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1555G>A; p.D519N; 3:184170062-184170062	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1617G>T; p.Q539H; 3:184170124-184170124	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.476A>G; p.N159S; 3:184164808-184164808	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1127G>A; p.G376D; 3:184166904-184166904	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1482C>T; p.F494F; 3:184168049-184168049	endometrium	carcinoma; serous_carcinoma	Substitution - coding silent
c.1771C>T; p.P591S; 3:184170375-184170375	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.900A>G; p.L300L; 3:184166262-184166262	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.658C>T; p.R220W; 3:184165171-184165171	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1203A>T; p.L401L; 3:184167584-184167584	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1580C>T; p.P527L; 3:184170087-184170087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1603G>A; p.A535T; 3:184170110-184170110	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.634C>T; p.R212C; 3:184165147-184165147	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.954A>G; p.V318V; 3:184166496-184166496	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1258G>A; p.A420T; 3:184167639-184167639	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.496C>T; p.R166W; 3:184164828-184164828	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1804G>A; p.G602S; 3:184170408-184170408	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1804G>A; p.G602S; 3:184170408-184170408	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.722C>T; p.S241F; 3:184165450-184165450	breast	carcinoma	Substitution - Missense
c.1661C>T; p.P554L; 3:184170168-184170168	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1198+1G>T; p.?; 3:184166976-184166976	lung	carcinoma; adenocarcinoma	Unknown
c.1299G>T; p.W433C; 3:184167680-184167680	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.845T>C; p.M282T; 3:184166207-184166207	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1960G>A; p.G654S; 3:184170564-184170564	large_intestine; colon	NS	Substitution - Missense
c.646A>G; p.R216G; 3:184165159-184165159	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.562A>G; p.S188G; 3:184164894-184164894	liver	carcinoma	Substitution - Missense
c.646A>G; p.R216G; 3:184165159-184165159	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.182C>T; p.S61L; 3:184163677-184163677	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1317T>C; p.P439P; 3:184167698-184167698	bone; rib	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.305C>A; p.P102H; 3:184164340-184164340	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.570T>A; p.F190L; 3:184164902-184164902	breast	carcinoma	Substitution - Missense
c.1377G>A; p.T459T; 3:184167944-184167944	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.569T>C; p.F190S; 3:184164901-184164901	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.569T>C; p.F190S; 3:184164901-184164901	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.569T>C; p.F190S; 3:184164901-184164901	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.183G>T; p.S61S; 3:184163678-184163678	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1088C>T; p.S363F; 3:184166865-184166865	skin	malignant_melanoma	Substitution - Missense
c.1545C>T; p.A515A; 3:184170052-184170052	skin	malignant_melanoma	Substitution - coding silent
c.1611G>A; p.P537P; 3:184170118-184170118	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.183G>A; p.S61S; 3:184163678-184163678	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.673A>C; p.K225Q; 3:184165186-184165186	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.745A>G; p.T249A; 3:184165473-184165473	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1726A>G; p.S576G; 3:184170330-184170330	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.819C>T; p.D273D; 3:184166181-184166181	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.920T>C; p.F307S; 3:184166462-184166462	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.440G>A; p.R147H; 3:184164578-184164578	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.849G>T; p.K283N; 3:184166211-184166211	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1202T>C; p.L401P; 3:184167583-184167583	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.514G>A; p.G172S; 3:184164846-184164846	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1690A>G; p.S564G; 3:184170197-184170197	urinary_tract; bladder	carcinoma	Substitution - Missense
c.822C>T; p.G274G; 3:184166184-184166184	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1848G>A; p.P616P; 3:184170452-184170452	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.567C>A; p.F189L; 3:184164899-184164899	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2103C>T; p.F701F; 3:184170707-184170707	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1486G>C; p.D496H; 3:184168053-184168053	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1242C>T; p.A414A; 3:184167623-184167623	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1510C>T; p.L504L; 3:184170017-184170017	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1730G>T; p.G577V; 3:184170334-184170334	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1505C>T; p.A502V; 3:184170012-184170012	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.411T>C; p.S137S; 3:184164549-184164549	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.411T>C; p.S137S; 3:184164549-184164549	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1899C>T; p.S633S; 3:184170503-184170503	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1050C>T; p.S350S; 3:184166827-184166827	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1917C>T; p.S639S; 3:184170521-184170521	skin	malignant_melanoma	Substitution - coding silent
c.1584G>A; p.G528G; 3:184170091-184170091	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1989delC; p.M666fs*2; 3:184170593-184170593	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1989delC; p.M666fs*2; 3:184170593-184170593	pancreas	carcinoma; acinar_carcinoma	Deletion - Frameshift
c.504A>G; p.R168R; 3:184164836-184164836	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1881G>A; p.P627P; 3:184170485-184170485	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1989delC; p.M666fs*2; 3:184170593-184170593	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.504A>G; p.R168R; 3:184164836-184164836	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.980G>T; p.G327V; 3:184166522-184166522	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2018C>T; p.P673L; 3:184170622-184170622	skin	malignant_melanoma	Substitution - Missense
c.2018C>T; p.P673L; 3:184170622-184170622	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1166C>T; p.S389F; 3:184166943-184166943	pancreas	carcinoma	Substitution - Missense
c.1166C>T; p.S389F; 3:184166943-184166943	skin	malignant_melanoma	Substitution - Missense
c.1545C>A; p.A515A; 3:184170052-184170052	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1871G>A; p.R624H; 3:184170475-184170475	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.388G>T; p.D130Y; 3:184164526-184164526	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.388G>T; p.D130Y; 3:184164526-184164526	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.423C>A; p.A141A; 3:184164561-184164561	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.423C>A; p.A141A; 3:184164561-184164561	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1394G>A; p.R465H; 3:184167961-184167961	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1286G>A; p.R429H; 3:184167667-184167667	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1464G>T; p.E488D; 3:184168031-184168031	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.596G>A; p.S199N; 3:184164928-184164928	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1414C>T; p.L472L; 3:184167981-184167981	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2012C>T; p.P671L; 3:184170616-184170616	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1991C>T; p.P664L; 3:184170595-184170595	skin	malignant_melanoma	Substitution - Missense
c.1187C>A; p.P396H; 3:184166964-184166964	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.404C>G; p.T135R; 3:184164542-184164542	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.978G>A; p.P326P; 3:184166520-184166520	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1206C>T; p.D402D; 3:184167587-184167587	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2123C>T; p.P708L; 3:184170727-184170727	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.503G>A; p.R168Q; 3:184164835-184164835	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1152C>G; p.I384M; 3:184166929-184166929	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.202C>T; p.P68S; 3:184163697-184163697	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1453A>T; p.T485S; 3:184168020-184168020	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.425A>T; p.Q142L; 3:184164563-184164563	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.692G>A; p.R231Q; 3:184165205-184165205	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.714C>T; p.I238I; 3:184165442-184165442	skin	malignant_melanoma	Substitution - coding silent
c.2094A>G; p.R698R; 3:184170698-184170698	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1461C>T; p.S487S; 3:184168028-184168028	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1692C>T; p.S564S; 3:184170199-184170199	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2043C>T; p.A681A; 3:184170647-184170647	skin	malignant_melanoma	Substitution - coding silent
c.594C>T; p.T198T; 3:184164926-184164926	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.125A>G; p.Y42C; 3:184155760-184155760	prostate	carcinoma	Substitution - Missense
c.1591C>A; p.P531T; 3:184170098-184170098	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2052C>T; p.G684G; 3:184170656-184170656	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.958C>T; p.R320W; 3:184166500-184166500	oesophagus	carcinoma	Substitution - Missense
c.876_878delCAT; p.I293delI; 3:184166238-184166240	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1754G>A; p.R585Q; 3:184170358-184170358	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.675G>A; p.K225K; 3:184165188-184165188	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1330G>A; p.G444S; 3:184167711-184167711	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.392A>G; p.N131S; 3:184164530-184164530	liver	carcinoma	Substitution - Missense
c.949C>T; p.R317W; 3:184166491-184166491	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.343C>A; p.P115T; 3:184164378-184164378	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1527C>T; p.H509H; 3:184170034-184170034	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.587A>G; p.D196G; 3:184164919-184164919	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062G>T; p.R354R; 3:184166839-184166839	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1833C>T; p.S611S; 3:184170437-184170437	breast	carcinoma	Substitution - coding silent
c.1747A>G; p.S583G; 3:184170351-184170351	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2120A>C; p.N707T; 3:184170724-184170724	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2120A>C; p.N707T; 3:184170724-184170724	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation