lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1856
Symbol	DVL2
Synonymous	-
Full name	dishevelled segment polarity protein 2
Gene description	dishevelled 2 (homologous to Drosophila dsh)\|dishevelled, dsh homolog 2\|segment polarity protein dishevelled homolog DVL-2
Cytoband	17p13.1
Gene type	protein-coding
Synonymous	MIM:602151; HGNC:HGNC:3086; Ensembl:ENSG00000004975; HPRD:03690; Vega:OTTHUMG00000102155

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1886delG; p.G629fs*52; 17:7226190-7226190	autonomic_ganglia	neuroblastoma	Deletion - Frameshift
c.2103C>T; p.A701A; 17:7225973-7225973	breast	carcinoma	Substitution - coding silent
c.405C>T; p.S135S; 17:7230290-7230290	thyroid	other; neoplasm	Substitution - coding silent
c.422C>A; p.S141Y; 17:7230144-7230144	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2013T>G; p.P671P; 17:7226063-7226063	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.321G>C; p.R107R; 17:7230374-7230374	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1243C>T; p.R415W; 17:7227524-7227524	bone; rib	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1761G>T; p.E587D; 17:7226422-7226422	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1190C>T; p.S397F; 17:7227696-7227696	urinary_tract; bladder	carcinoma	Substitution - Missense
c.789C>T; p.L263L; 17:7229406-7229406	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.108G>A; p.E36E; 17:7234155-7234155	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.789C>T; p.L263L; 17:7229406-7229406	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.1724C>A; p.T575N; 17:7226459-7226459	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.401C>T; p.P134L; 17:7230294-7230294	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.226G>A; p.A76T; 17:7230766-7230766	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.735C>T; p.P245P; 17:7229600-7229600	skin	malignant_melanoma	Substitution - coding silent
c.1338G>T; p.K446N; 17:7227429-7227429	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1338G>T; p.K446N; 17:7227429-7227429	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.110G>T; p.R37L; 17:7234153-7234153	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1656C>T; p.S552S; 17:7226527-7226527	liver	carcinoma	Substitution - coding silent
c.937C>T; p.P313S; 17:7229155-7229155	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1656C>T; p.S552S; 17:7226527-7226527	liver	carcinoma	Substitution - coding silent
c.2174T>C; p.M725T; 17:7225902-7225902	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1253_1254CC>TT; p.S418F; 17:7227513-7227514	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1360C>T; p.L454L; 17:7227407-7227407	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.324A>G; p.A108A; 17:7230371-7230371	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.23delG; p.G8fs*9; 17:7234240-7234240	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1076C>A; p.P359H; 17:7228003-7228003	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1522C>A; p.L508I; 17:7227111-7227111	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.641A>G; p.E214G; 17:7229823-7229823	skin	malignant_melanoma	Substitution - Missense
c.1849G>A; p.G617S; 17:7226227-7226227	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.87G>A; p.V29V; 17:7234176-7234176	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.795C>T; p.I265I; 17:7229400-7229400	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.935A>G; p.E312G; 17:7229157-7229157	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.229C>T; p.R77C; 17:7230763-7230763	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.229C>T; p.R77C; 17:7230763-7230763	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.464C>T; p.S155L; 17:7230102-7230102	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1000G>A; p.V334M; 17:7229003-7229003	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.807G>A; p.T269T; 17:7229388-7229388	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1510G>A; p.V504I; 17:7227123-7227123	central_nervous_system; brain	glioma	Substitution - Missense
c.865C>T; p.R289W; 17:7229227-7229227	skin	malignant_melanoma	Substitution - Missense
c.1324C>T; p.R442C; 17:7227443-7227443	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1632C>A; p.P544P; 17:7226551-7226551	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.660C>T; p.F220F; 17:7229675-7229675	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.35G>A; p.G12E; 17:7234228-7234228	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.207A>C; p.E69D; 17:7230785-7230785	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1701C>A; p.P567P; 17:7226482-7226482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1359T>A; p.F453L; 17:7227408-7227408	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.181G>A; p.D61N; 17:7234082-7234082	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.809T>G; p.L270R; 17:7229386-7229386	thyroid	other; neoplasm	Substitution - Missense
c.343C>T; p.P115S; 17:7230352-7230352	skin	malignant_melanoma	Substitution - Missense
c.1308A>G; p.G436G; 17:7227459-7227459	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1688C>T; p.P563L; 17:7226495-7226495	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1519G>A; p.D507N; 17:7227114-7227114	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.766G>A; p.V256I; 17:7229429-7229429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.737G>A; p.R246H; 17:7229598-7229598	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.737G>A; p.R246H; 17:7229598-7229598	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.737G>A; p.R246H; 17:7229598-7229598	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.698T>G; p.L233R; 17:7229637-7229637	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1685G>A; p.S562N; 17:7226498-7226498	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1894C>T; p.R632W; 17:7226182-7226182	urinary_tract; bladder	carcinoma	Substitution - Missense
c.929G>A; p.R310H; 17:7229163-7229163	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1092T>A; p.T364T; 17:7227987-7227987	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.197T>G; p.V66G; 17:7230795-7230795	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.197T>G; p.V66G; 17:7230795-7230795	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.210A>C; p.E70D; 17:7230782-7230782	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.819G>T; p.E273D; 17:7229273-7229273	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1873T>C; p.S625P; 17:7226203-7226203	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.845T>C; p.I282T; 17:7229247-7229247	kidney	carcinoma	Substitution - Missense
c.1409C>T; p.P470L; 17:7227224-7227224	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1474G>A; p.V492I; 17:7227159-7227159	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1474G>A; p.V492I; 17:7227159-7227159	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1474G>A; p.V492I; 17:7227159-7227159	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1474G>A; p.V492I; 17:7227159-7227159	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1465C>A; p.R489R; 17:7227168-7227168	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.514C>G; p.H172D; 17:7230052-7230052	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1408C>G; p.P470A; 17:7227225-7227225	skin	malignant_melanoma	Substitution - Missense
c.2143A>C; p.T715P; 17:7225933-7225933	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.570C>T; p.A190A; 17:7229894-7229894	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.723G>A; p.K241K; 17:7229612-7229612	skin	malignant_melanoma	Substitution - coding silent
c.1801delG; p.A601fs*80; 17:7226275-7226275	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1801delG; p.A601fs*80; 17:7226275-7226275	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1801delG; p.A601fs*80; 17:7226275-7226275	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1689G>A; p.P563P; 17:7226494-7226494	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2185A>T; p.S729C; 17:7225891-7225891	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1444C>T; p.L482L; 17:7227189-7227189	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1003C>T; p.R335W; 17:7229000-7229000	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1003C>T; p.R335W; 17:7229000-7229000	skin	malignant_melanoma	Substitution - Missense
c.983T>C; p.M328T; 17:7229020-7229020	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.710G>A; p.R237Q; 17:7229625-7229625	urinary_tract; bladder	carcinoma	Substitution - Missense
c.653G>T; p.S218I; 17:7229811-7229811	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1325G>A; p.R442H; 17:7227442-7227442	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2163C>T; p.F721F; 17:7225913-7225913	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.801A>G; p.T267T; 17:7229394-7229394	central_nervous_system; brain	glioma	Substitution - coding silent
c.236C>T; p.P79L; 17:7230756-7230756	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1613C>T; p.P538L; 17:7226570-7226570	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation