lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1855
Symbol	DVL1
Synonymous	DRS2\|DVL\|DVL1L1\|DVL1P1
Full name	dishevelled segment polarity protein 1
Gene description	DSH homolog 1\|dishevelled 1 (homologous to Drosophila dsh)\|dishevelled, dsh homolog 1\|dishevelled-1\|segment polarity protein dishevelled homolog DVL-1
Cytoband	1p36
Gene type	protein-coding
Synonymous	MIM:601365; HGNC:HGNC:3084; Ensembl:ENSG00000107404; HPRD:03220; Vega:OTTHUMG00000003069

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1395C>T; p.S465S; 1:1338306-1338306	skin	malignant_melanoma	Substitution - coding silent
c.823G>C; p.D275H; 1:1340124-1340124	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1275G>C; p.V425V; 1:1338426-1338426	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1273G>A; p.V425M; 1:1338428-1338428	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.685C>T; p.R229W; 1:1340424-1340424	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.723C>T; p.T241T; 1:1340293-1340293	skin	malignant_melanoma	Substitution - coding silent
c.972C>T; p.I324I; 1:1339750-1339750	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.972C>T; p.I324I; 1:1339750-1339750	skin	malignant_melanoma	Substitution - coding silent
c.1236C>G; p.L412L; 1:1338550-1338550	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1508C>A; p.P503Q; 1:1338108-1338108	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.331G>T; p.G111C; 1:1342394-1342394	liver	carcinoma	Substitution - Missense
c.1226G>A; p.R409H; 1:1338560-1338560	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1785G>A; p.P595P; 1:1336370-1336370	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.410C>T; p.T137M; 1:1342109-1342109	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.448C>T; p.R150C; 1:1342071-1342071	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1177G>A; p.V393I; 1:1338609-1338609	pancreas	carcinoma	Substitution - Missense
c.1710G>A; p.A570A; 1:1336445-1336445	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.130G>T; p.A44S; 1:1348936-1348936	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1149G>A; p.P383P; 1:1338637-1338637	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1550A>T; p.Y517F; 1:1338066-1338066	breast	carcinoma	Substitution - Missense
c.1760T>G; p.V587G; 1:1336395-1336395	urinary_tract; bladder	carcinoma	Substitution - Missense
c.686G>T; p.R229L; 1:1340423-1340423	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.366A>G; p.P122P; 1:1342153-1342153	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1334A>T; p.Y445F; 1:1338367-1338367	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.852G>A; p.M284I; 1:1340095-1340095	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1174G>A; p.A392T; 1:1338612-1338612	pancreas	carcinoma	Substitution - Missense
c.1184G>T; p.R395L; 1:1338602-1338602	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1998C>T; p.F666F; 1:1336157-1336157	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.741C>G; p.L247L; 1:1340275-1340275	kidney	other; neoplasm	Substitution - coding silent
c.857G>A; p.G286D; 1:1340090-1340090	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.759G>A; p.T253T; 1:1340257-1340257	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.978C>T; p.S326S; 1:1339744-1339744	skin	malignant_melanoma	Substitution - coding silent
c.1062G>A; p.P354P; 1:1339432-1339432	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.288G>A; p.T96T; 1:1342437-1342437	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.432G>A; p.R144R; 1:1342087-1342087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.679C>T; p.R227C; 1:1340430-1340430	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.870C>T; p.A290A; 1:1340077-1340077	skin	malignant_melanoma	Substitution - coding silent
c.1741C>T; p.H581Y; 1:1336414-1336414	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.965G>A; p.R322Q; 1:1339757-1339757	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1574C>T; p.P525L; 1:1338042-1338042	liver	carcinoma	Substitution - Missense
c.1574C>T; p.P525L; 1:1338042-1338042	liver	carcinoma	Substitution - Missense
c.850A>G; p.M284V; 1:1340097-1340097	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.850A>G; p.M284V; 1:1340097-1340097	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1899C>T; p.P633P; 1:1336256-1336256	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.747C>T; p.I249I; 1:1340269-1340269	skin	malignant_melanoma	Substitution - coding silent
c.458G>A; p.R153H; 1:1342061-1342061	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1330A>G; p.K444E; 1:1338371-1338371	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.960G>T; p.V320V; 1:1339762-1339762	breast	carcinoma	Substitution - coding silent
c.1497G>A; p.P499P; 1:1338119-1338119	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.195T>C; p.D65D; 1:1342734-1342734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.452G>A; p.R151Q; 1:1342067-1342067	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.223G>A; p.G75S; 1:1342706-1342706	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1461C>T; p.G487G; 1:1338155-1338155	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.858C>T; p.G286G; 1:1340089-1340089	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1319G>A; p.R440Q; 1:1338382-1338382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.435G>T; p.R145R; 1:1342084-1342084	kidney	other; neoplasm	Substitution - coding silent
c.717C>T; p.S239S; 1:1340299-1340299	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.621G>T; p.T207T; 1:1340488-1340488	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1134G>T; p.E378D; 1:1338652-1338652	fallopian_tube	carcinoma; serous_carcinoma	Substitution - Missense
c.1367G>A; p.R456Q; 1:1338334-1338334	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.440G>T; p.R147L; 1:1342079-1342079	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.798C>T; p.I266I; 1:1340149-1340149	skin	malignant_melanoma	Substitution - coding silent
c.1217T>C; p.I406T; 1:1338569-1338569	kidney	other; neoplasm	Substitution - Missense
c.1399C>T; p.Q467*; 1:1338302-1338302	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1146G>A; p.A382A; 1:1338640-1338640	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.951C>T; p.A317A; 1:1339771-1339771	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1785G>T; p.P595P; 1:1336370-1336370	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.809G>T; p.S270I; 1:1340138-1340138	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1706C>T; p.A569V; 1:1336449-1336449	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.941A>G; p.N314S; 1:1339781-1339781	pancreas	carcinoma	Substitution - Missense
c.900G>T; p.M300I; 1:1340047-1340047	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1050A>G; p.P350P; 1:1339586-1339586	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1084G>A; p.A362T; 1:1339410-1339410	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.504G>A; p.R168R; 1:1341768-1341768	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1989C>T; p.C663C; 1:1336166-1336166	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.818G>A; p.R273H; 1:1340129-1340129	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>A; p.S177R; 1:1341741-1341741	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.227G>A; p.R76H; 1:1342702-1342702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.817C>T; p.R273C; 1:1340130-1340130	breast	carcinoma	Substitution - Missense
c.680G>A; p.R227H; 1:1340429-1340429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.818G>T; p.R273L; 1:1340129-1340129	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1061C>T; p.P354L; 1:1339433-1339433	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1272C>T; p.D424D; 1:1338429-1338429	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1854G>A; p.P618P; 1:1336301-1336301	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.141C>A; p.F47L; 1:1348925-1348925	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.824A>G; p.D275G; 1:1340123-1340123	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1830G>A; p.S610S; 1:1336325-1336325	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1830G>A; p.S610S; 1:1336325-1336325	skin	malignant_melanoma	Substitution - coding silent
c.311C>T; p.P104L; 1:1342414-1342414	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.409A>T; p.T137S; 1:1342110-1342110	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1687C>T; p.R563C; 1:1336468-1336468	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1687C>T; p.R563C; 1:1336468-1336468	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1628A>T; p.Q543L; 1:1337988-1337988	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1257C>T; p.A419A; 1:1338529-1338529	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation