lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1808
Symbol	DPYSL2
Synonymous	CRMP-2\|CRMP2\|DHPRP2\|DRP-2\|DRP2\|N2A3\|ULIP-2\|ULIP2
Full name	dihydropyrimidinase-like 2
Gene description	collapsin response mediator protein hCRMP-2\|dihydropyrimidinase-related protein 2\|unc-33-like phosphoprotein 2
Cytoband	8p22-p21
Gene type	protein-coding
Synonymous	MIM:602463; HGNC:HGNC:3014; Ensembl:ENSG00000092964; HPRD:03914; Vega:OTTHUMG00000099439

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1543C>T; p.P515S; 8:26653313-26653313	skin	malignant_melanoma	Substitution - Missense
c.506C>A; p.A169D; 8:26626644-26626644	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1221C>T; p.A407A; 8:26647740-26647740	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1082G>A; p.R361Q; 8:26644063-26644063	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1526C>T; p.T509M; 8:26653296-26653296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1110+9C>T; p.?; 8:26644100-26644100	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.223C>T; p.R75C; 8:26583893-26583893	skin	malignant_melanoma	Substitution - Missense
c.1441C>T; p.R481C; 8:26652416-26652416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.712C>T; p.R238C; 8:26634801-26634801	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1343G>A; p.S448N; 8:26652318-26652318	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.885G>T; p.W295C; 8:26643512-26643512	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.987G>A; p.T329T; 8:26643968-26643968	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1683C>A; p.P561P; 8:26655670-26655670	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.556A>T; p.S186C; 8:26627230-26627230	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1682C>T; p.P561L; 8:26655669-26655669	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1472T>A; p.L491Q; 8:26653242-26653242	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1015G>T; p.A339S; 8:26643996-26643996	stomach	adenocarcinoma	Substitution - Missense
c.1378C>G; p.H460D; 8:26652353-26652353	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1628G>A; p.G543D; 8:26655615-26655615	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1628G>A; p.G543D; 8:26655615-26655615	large_intestine; colon	carcinoma	Substitution - Missense
c.1628G>A; p.G543D; 8:26655615-26655615	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>A; p.A199T; 8:26627269-26627269	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.577G>A; p.A193T; 8:26627251-26627251	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1595G>A; p.R532Q; 8:26653365-26653365	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.577G>A; p.A193T; 8:26627251-26627251	breast	carcinoma	Substitution - Missense
c.1055C>T; p.P352L; 8:26644036-26644036	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1681_1682CC>TT; p.P561F; 8:26655668-26655669	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1644C>T; p.D548D; 8:26655631-26655631	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1306G>T; p.G436C; 8:26652281-26652281	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.272A>G; p.Q91R; 8:26583942-26583942	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1527G>A; p.T509T; 8:26653297-26653297	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1527G>A; p.T509T; 8:26653297-26653297	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.18G>A; p.K6K; 8:26578272-26578272	skin	malignant_melanoma	Substitution - coding silent
c.15G>A; p.G5G; 8:26578269-26578269	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.956C>T; p.S319F; 8:26643583-26643583	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.541A>G; p.I181V; 8:26627215-26627215	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.198C>G; p.I66M; 8:26583868-26583868	breast	carcinoma	Substitution - Missense
c.224G>A; p.R75H; 8:26583894-26583894	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1243G>A; p.D415N; 8:26647762-26647762	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1092C>T; p.V364V; 8:26644073-26644073	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1462-7T>G; p.?; 8:26653225-26653225	oesophagus	carcinoma; adenocarcinoma	Unknown
c.1443T>C; p.R481R; 8:26652418-26652418	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1443T>C; p.R481R; 8:26652418-26652418	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.175G>A; p.E59K; 8:26583845-26583845	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.547G>A; p.E183K; 8:26627221-26627221	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1386C>T; p.T462T; 8:26652361-26652361	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1056G>A; p.P352P; 8:26644037-26644037	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.398G>T; p.C133F; 8:26624227-26624227	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1466C>T; p.A489V; 8:26653236-26653236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1110+10G>A; p.?; 8:26644101-26644101	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.726C>T; p.I242I; 8:26634815-26634815	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1537G>A; p.V513I; 8:26653307-26653307	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.802C>T; p.R268W; 8:26634891-26634891	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1249G>A; p.V417I; 8:26647768-26647768	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>A; p.A267T; 8:26634888-26634888	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.792C>T; p.I264I; 8:26634881-26634881	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1681delC; p.G563fs*>10; 8:26655668-26655668	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1215C>T; p.S405S; 8:26647734-26647734	skin	malignant_melanoma	Substitution - coding silent
c.70A>C; p.I24L; 8:26581999-26581999	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1669C>T; p.R557C; 8:26655656-26655656	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.660C>T; p.P220P; 8:26627910-26627910	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.830A>G; p.E277G; 8:26643457-26643457	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.918C>T; p.P306P; 8:26643545-26643545	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.540+1G>T; p.?; 8:26626679-26626679	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.803G>A; p.R268Q; 8:26634892-26634892	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.727G>A; p.A243T; 8:26634816-26634816	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1089C>T; p.S363S; 8:26644070-26644070	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1479G>A; p.G493G; 8:26653249-26653249	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.447G>T; p.Q149H; 8:26624276-26624276	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1714G>T; p.G572C; 8:26655701-26655701	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.859G>A; p.G287S; 8:26643486-26643486	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.859G>A; p.G287S; 8:26643486-26643486	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.284C>T; p.A95V; 8:26583954-26583954	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.414T>C; p.H138H; 8:26624243-26624243	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.496G>A; p.V166M; 8:26626634-26626634	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.415G>A; p.V139M; 8:26624244-26624244	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1548C>T; p.A516A; 8:26653318-26653318	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1212A>T; p.G404G; 8:26647731-26647731	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.47G>A; p.R16H; 8:26581976-26581976	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1399C>T; p.R467C; 8:26652374-26652374	urinary_tract; bladder	carcinoma	Substitution - Missense
c.702A>T; p.E234D; 8:26634791-26634791	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.900C>T; p.A300A; 8:26643527-26643527	skin	malignant_melanoma	Substitution - coding silent
c.1230C>T; p.V410V; 8:26647749-26647749	kidney	other; neoplasm	Substitution - coding silent
c.1230C>T; p.V410V; 8:26647749-26647749	skin	malignant_melanoma	Substitution - coding silent
c.1216G>A; p.D406N; 8:26647735-26647735	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.771C>T; p.S257S; 8:26634860-26634860	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.795C>A; p.A265A; 8:26634884-26634884	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.380C>T; p.A127V; 8:26624209-26624209	skin	malignant_melanoma	Substitution - Missense
c.607G>A; p.D203N; 8:26627281-26627281	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1500C>T; p.D500D; 8:26653270-26653270	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.606C>T; p.G202G; 8:26627280-26627280	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.537C>T; p.C179C; 8:26626675-26626675	central_nervous_system; brain	glioma	Substitution - coding silent
c.606C>T; p.G202G; 8:26627280-26627280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.442A>G; p.I148V; 8:26624271-26624271	liver	carcinoma	Substitution - Missense
c.442A>G; p.I148V; 8:26624271-26624271	liver	carcinoma	Substitution - Missense
c.536G>A; p.C179Y; 8:26626674-26626674	breast	carcinoma	Substitution - Missense
c.517C>T; p.R173C; 8:26626655-26626655	skin	malignant_melanoma	Substitution - Missense
c.1099G>A; p.D367N; 8:26644080-26644080	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.957C>T; p.S319S; 8:26643584-26643584	skin	malignant_melanoma	Substitution - coding silent
c.352G>A; p.A118T; 8:26624181-26624181	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1090G>A; p.V364I; 8:26644071-26644071	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.287C>T; p.A96V; 8:26583957-26583957	pancreas	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation