lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1803
Symbol	DPP4
Synonymous	ADABP\|ADCP2\|CD26\|DPPIV\|TP103
Full name	dipeptidyl-peptidase 4
Gene description	ADCP-2\|DPP IV\|T-cell activation antigen CD26\|adenosine deaminase complexing protein 2\|dipeptidyl peptidase 4\|dipeptidyl peptidase IV\|dipeptidylpeptidase 4\|dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Cytoband	2q24.3
Gene type	protein-coding
Synonymous	MIM:102720; HGNC:HGNC:3009; Ensembl:ENSG00000197635; HPRD:02187; Vega:OTTHUMG00000132056

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.349G>T; p.E117*; 2:162045549-162045549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.555C>A; p.I185I; 2:162038360-162038360	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.555C>A; p.I185I; 2:162038360-162038360	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1859A>G; p.D620G; 2:162009269-162009269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.663T>C; p.T221T; 2:162035275-162035275	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1023+3G>A; p.?; 2:162024801-162024801	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.365A>C; p.K122T; 2:162045533-162045533	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.916G>A; p.A306T; 2:162024911-162024911	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1469-1_1469GG>AA; p.?; 2:162016866-162016867	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.360C>T; p.Y120Y; 2:162045538-162045538	pancreas	carcinoma	Substitution - coding silent
c.360C>T; p.Y120Y; 2:162045538-162045538	pancreas	carcinoma	Substitution - coding silent
c.1780A>G; p.I594V; 2:162011845-162011845	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.67G>A; p.V23M; 2:162073426-162073426	breast	carcinoma	Substitution - Missense
c.1061T>G; p.V354G; 2:162022762-162022762	thyroid	other; neoplasm	Substitution - Missense
c.2113G>A; p.G705R; 2:161995312-161995312	skin	malignant_melanoma	Substitution - Missense
c.1868G>A; p.R623Q; 2:162009260-162009260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1868G>A; p.R623Q; 2:162009260-162009260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1868G>A; p.R623Q; 2:162009260-162009260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1868G>A; p.R623Q; 2:162009260-162009260	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1394C>T; p.A465V; 2:162018755-162018755	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1731C>A; p.S577R; 2:162011894-162011894	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1394C>T; p.A465V; 2:162018755-162018755	breast	carcinoma	Substitution - Missense
c.1926G>A; p.S642S; 2:162008623-162008623	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1215C>T; p.I405I; 2:162020258-162020258	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.688G>A; p.D230N; 2:162035250-162035250	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1360T>A; p.C454S; 2:162018789-162018789	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.319A>G; p.I107V; 2:162045579-162045579	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.27G>T; p.L9L; 2:162073466-162073466	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2269C>T; p.H757Y; 2:161993315-161993315	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.875C>T; p.S292F; 2:162033553-162033553	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1994T>C; p.V665A; 2:162005803-162005803	liver	carcinoma	Substitution - Missense
c.2053-1G>T; p.?; 2:161995373-161995373	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1863C>T; p.N621N; 2:162009265-162009265	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.658G>A; p.G220S; 2:162035280-162035280	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.G220S; 2:162035280-162035280	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1456G>A; p.V486M; 2:162017120-162017120	breast	carcinoma	Substitution - Missense
c.1610C>T; p.S537F; 2:162014423-162014423	skin	malignant_melanoma	Substitution - Missense
c.1333C>T; p.L445F; 2:162018816-162018816	skin	malignant_melanoma	Substitution - Missense
c.2239G>T; p.A747S; 2:161993345-161993345	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.917C>T; p.A306V; 2:162024910-162024910	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1395G>A; p.A465A; 2:162018754-162018754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1395G>A; p.A465A; 2:162018754-162018754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1947T>C; p.C649C; 2:162008602-162008602	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1395G>A; p.A465A; 2:162018754-162018754	skin	malignant_melanoma	Substitution - coding silent
c.1395G>A; p.A465A; 2:162018754-162018754	pancreas	carcinoma	Substitution - coding silent
c.1395G>A; p.A465A; 2:162018754-162018754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1459A>C; p.N487H; 2:162017117-162017117	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1299-1G>T; p.?; 2:162018851-162018851	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1468+1G>A; p.?; 2:162017107-162017107	skin	malignant_melanoma	Unknown
c.878T>C; p.M293T; 2:162033550-162033550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.878T>C; p.M293T; 2:162033550-162033550	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.250G>A; p.G84R; 2:162046950-162046950	skin	malignant_melanoma	Substitution - Missense
c.2221G>A; p.G741R; 2:161993363-161993363	skin	malignant_melanoma	Substitution - Missense
c.1377_1378delGT; p.S460fs*3; 2:162018771-162018772	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1498T>C; p.L500L; 2:162016837-162016837	skin	malignant_melanoma	Substitution - coding silent
c.2298T>G; p.P766P; 2:161993286-161993286	skin	malignant_melanoma	Substitution - coding silent
c.564G>A; p.T188T; 2:162038351-162038351	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1189A>G; p.I397V; 2:162020284-162020284	liver	carcinoma	Substitution - Missense
c.867T>C; p.A289A; 2:162033561-162033561	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2097G>A; p.E699E; 2:161995328-161995328	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.980T>C; p.I327T; 2:162024847-162024847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.165G>T; p.L55L; 2:162047431-162047431	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1067G>A; p.R356K; 2:162022756-162022756	breast	carcinoma	Substitution - Missense
c.868C>T; p.P290S; 2:162033560-162033560	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.286-1G>A; p.?; 2:162045613-162045613	lung	carcinoma; adenocarcinoma	Unknown
c.1050T>C; p.T350T; 2:162022773-162022773	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.940C>T; p.Q314*; 2:162024887-162024887	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Nonsense
c.1770C>T; p.I590I; 2:162011855-162011855	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1717A>G; p.I573V; 2:162011908-162011908	liver	carcinoma	Substitution - Missense
c.1271G>A; p.G424E; 2:162019250-162019250	skin	malignant_melanoma	Substitution - Missense
c.1717A>G; p.I573V; 2:162011908-162011908	liver	carcinoma	Substitution - Missense
c.889G>A; p.D297N; 2:162024938-162024938	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2002G>A; p.E668K; 2:162005795-162005795	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.632A>G; p.Y211C; 2:162035306-162035306	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1903G>A; p.V635I; 2:162008646-162008646	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.888G>A; p.G296G; 2:162024939-162024939	skin	malignant_melanoma	Substitution - coding silent
c.361G>A; p.V121M; 2:162045537-162045537	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.193+5G>T; p.?; 2:162047398-162047398	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.929G>T; p.R310I; 2:162024898-162024898	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.517T>C; p.Y173H; 2:162038398-162038398	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.699C>T; p.V233V; 2:162035239-162035239	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1633G>T; p.D545Y; 2:162014400-162014400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.342T>G; p.I114M; 2:162045556-162045556	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1046G>A; p.S349N; 2:162022777-162022777	liver	carcinoma	Substitution - Missense
c.194-1G>T; p.?; 2:162047007-162047007	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1046G>A; p.S349N; 2:162022777-162022777	liver	carcinoma	Substitution - Missense
c.1630T>G; p.L544V; 2:162014403-162014403	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.869C>T; p.P290L; 2:162033559-162033559	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.943T>G; p.W315G; 2:162024884-162024884	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.217G>T; p.E73*; 2:162046983-162046983	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.288T>C; p.D96D; 2:162045610-162045610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2072G>T; p.R691I; 2:161995353-161995353	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1462G>A; p.D488N; 2:162017114-162017114	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.360C>A; p.Y120*; 2:162045538-162045538	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.896A>T; p.Y299F; 2:162024931-162024931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458A>T; p.Q153L; 2:162038983-162038983	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.926A>G; p.E309G; 2:162024901-162024901	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.542C>T; p.P181L; 2:162038373-162038373	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1745G>A; p.G582E; 2:162011880-162011880	skin	malignant_melanoma	Substitution - Missense
c.1014C>A; p.N338K; 2:162024813-162024813	ovary	other; neoplasm	Substitution - Missense
c.536A>G; p.N179S; 2:162038379-162038379	skin	malignant_melanoma	Substitution - Missense
c.1014C>A; p.N338K; 2:162024813-162024813	ovary	other; neoplasm	Substitution - Missense
c.1753T>C; p.Y585H; 2:162011872-162011872	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.16A>G; p.K6E; 2:162073477-162073477	skin	malignant_melanoma	Substitution - Missense
c.687C>T; p.N229N; 2:162035251-162035251	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1180T>A; p.C394S; 2:162020293-162020293	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1730G>C; p.S577T; 2:162011895-162011895	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1078T>C; p.S360P; 2:162020679-162020679	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1458G>A; p.V486V; 2:162017118-162017118	skin	malignant_melanoma	Substitution - coding silent
c.1617A>C; p.K539N; 2:162014416-162014416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1947T>A; p.C649*; 2:162008602-162008602	pancreas	carcinoma	Substitution - Nonsense
c.1947T>A; p.C649*; 2:162008602-162008602	pancreas	carcinoma	Substitution - Nonsense
c.535A>G; p.N179D; 2:162038380-162038380	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.935C>A; p.S312Y; 2:162024892-162024892	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.935C>A; p.S312Y; 2:162024892-162024892	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.935C>A; p.S312Y; 2:162024892-162024892	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1567+3A>G; p.?; 2:162016765-162016765	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.2092G>T; p.V698F; 2:161995333-161995333	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.515T>G; p.I172S; 2:162038400-162038400	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1928G>A; p.G643E; 2:162008621-162008621	skin	malignant_melanoma	Substitution - Missense
c.1245-5C>T; p.?; 2:162019281-162019281	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.24T>C; p.L8L; 2:162073469-162073469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2176G>A; p.V726I; 2:161994984-161994984	central_nervous_system; brain	glioma	Substitution - Missense
c.888G>T; p.G296G; 2:162024939-162024939	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2222G>A; p.G741E; 2:161993362-161993362	breast	carcinoma	Substitution - Missense
c.1029G>A; p.R343R; 2:162022794-162022794	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1366T>C; p.Y456H; 2:162018783-162018783	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1023+10A>G; p.?; 2:162024794-162024794	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1084C>T; p.P362S; 2:162020673-162020673	skin; subungual	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.1084C>T; p.P362S; 2:162020673-162020673	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1309_1322del14; p.Y439fs*5; 2:162018827-162018840	prostate	carcinoma	Deletion - Frameshift
c.237C>T; p.F79F; 2:162046963-162046963	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1869A>G; p.R623R; 2:162009259-162009259	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.46G>T; p.A16S; 2:162073447-162073447	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1059G>A; p.W353*; 2:162022764-162022764	NS	malignant_melanoma	Substitution - Nonsense
c.1059G>A; p.W353*; 2:162022764-162022764	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Nonsense
c.1059G>A; p.W353*; 2:162022764-162022764	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Nonsense
c.2173G>A; p.D725N; 2:161994987-161994987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2073A>G; p.R691R; 2:161995352-161995352	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2199+1G>A; p.?; 2:161994960-161994960	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1921G>A; p.G641R; 2:162008628-162008628	skin	malignant_melanoma	Substitution - Missense
c.481G>T; p.G161C; 2:162038960-162038960	central_nervous_system; brain	glioma	Substitution - Missense
c.1760G>A; p.G587E; 2:162011865-162011865	skin	malignant_melanoma	Substitution - Missense
c.1475G>C; p.R492T; 2:162016860-162016860	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.960G>C; p.Q320H; 2:162024867-162024867	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1961C>T; p.A654V; 2:162008588-162008588	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2278A>C; p.K760Q; 2:161993306-161993306	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1351C>T; p.P451S; 2:162018798-162018798	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1940T>C; p.F647S; 2:162008609-162008609	urinary_tract; bladder	carcinoma	Substitution - Missense
c.326C>T; p.P109L; 2:162045572-162045572	skin	malignant_melanoma	Substitution - Missense
c.119G>A; p.R40H; 2:162047477-162047477	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.779G>C; p.G260A; 2:162033649-162033649	breast	carcinoma	Substitution - Missense
c.1051A>G; p.T351A; 2:162022772-162022772	breast	carcinoma	Substitution - Missense
c.2199G>A; p.M733I; 2:161994961-161994961	skin	malignant_melanoma	Substitution - Missense
c.1493C>T; p.S498L; 2:162016842-162016842	breast	carcinoma	Substitution - Missense
c.1462G>T; p.D488Y; 2:162017114-162017114	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.928A>G; p.R310G; 2:162024899-162024899	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2241A>T; p.A747A; 2:161993343-161993343	pancreas	carcinoma	Substitution - coding silent
c.1421G>A; p.G474D; 2:162017155-162017155	pancreas	carcinoma	Substitution - Missense
c.1539delA; p.K513fs*7; 2:162016796-162016796	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2001A>T; p.T667T; 2:162005796-162005796	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1972C>T; p.R658W; 2:162008577-162008577	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1011G>T; p.W337C; 2:162024816-162024816	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1857G>T; p.V619V; 2:162009271-162009271	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation