lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1796
Symbol	DOK1
Synonymous	P62DOK
Full name	docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Gene description	Downstream of tyrosine kinase 1\|docking protein 1\|docking protein 1 (downstream of tyrosine kinase 1)\|p62(dok)\|pp62
Cytoband	2p13
Gene type	protein-coding
Synonymous	MIM:602919; HGNC:HGNC:2990; Ensembl:ENSG00000115325; HPRD:04228; Vega:OTTHUMG00000129956

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1400G>A; p.R467K; 2:74557068-74557068	skin	malignant_melanoma	Substitution - Missense
c.949G>A; p.D317N; 2:74556617-74556617	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.929C>T; p.S310F; 2:74556597-74556597	breast	carcinoma	Substitution - Missense
c.894G>A; p.E298E; 2:74556562-74556562	liver	carcinoma	Substitution - coding silent
c.597G>A; p.L199L; 2:74556036-74556036	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.43C>A; p.Q15K; 2:74554797-74554797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1244G>A; p.R415Q; 2:74556912-74556912	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1412A>G; p.D471G; 2:74557080-74557080	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.622C>T; p.R208C; 2:74556061-74556061	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.651T>A; p.S217S; 2:74556319-74556319	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.94G>A; p.A32T; 2:74555187-74555187	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.376C>T; p.L126L; 2:74555590-74555590	oesophagus	carcinoma	Substitution - coding silent
c.797G>C; p.R266T; 2:74556465-74556465	breast	carcinoma	Substitution - Missense
c.1419_1420delTG; p.V475fs*>7; 2:74557087-74557088	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1176G>T; p.R392R; 2:74556844-74556844	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.29delT; p.L12fs*26; 2:74554783-74554783	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.29delT; p.L12fs*26; 2:74554783-74554783	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.138G>T; p.K46N; 2:74555231-74555231	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.43C>T; p.Q15*; 2:74554797-74554797	breast	carcinoma	Substitution - Nonsense
c.570C>T; p.A190A; 2:74556009-74556009	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.562G>T; p.V188L; 2:74556001-74556001	liver	carcinoma	Substitution - Missense
c.562G>T; p.V188L; 2:74556001-74556001	liver	carcinoma	Substitution - Missense
c.851G>A; p.G284D; 2:74556519-74556519	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.239delC; p.P82fs*76; 2:74555332-74555332	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.256G>T; p.A86S; 2:74555349-74555349	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.786C>T; p.H262H; 2:74556454-74556454	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1031C>T; p.A344V; 2:74556699-74556699	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1412A>C; p.D471A; 2:74557080-74557080	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.632G>A; p.R211Q; 2:74556071-74556071	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1125C>T; p.G375G; 2:74556793-74556793	breast	carcinoma	Substitution - coding silent
c.172C>T; p.R58C; 2:74555265-74555265	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.380C>T; p.A127V; 2:74555594-74555594	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1384G>A; p.D462N; 2:74557052-74557052	thyroid	carcinoma	Substitution - Missense
c.1229C>A; p.A410D; 2:74556897-74556897	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.325G>T; p.A109S; 2:74555418-74555418	soft_tissue; striated_muscle	rhabdomyosarcoma; alveolar	Substitution - Missense
c.78G>T; p.W26C; 2:74555171-74555171	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.526C>G; p.L176V; 2:74555965-74555965	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1094C>A; p.P365H; 2:74556762-74556762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1390G>A; p.G464R; 2:74557058-74557058	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1390G>A; p.G464R; 2:74557058-74557058	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.36G>A; p.L12L; 2:74554790-74554790	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1330C>G; p.H444D; 2:74556998-74556998	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1118C>T; p.P373L; 2:74556786-74556786	skin	malignant_melanoma	Substitution - Missense
c.896_897CC>TT; p.P299L; 2:74556564-74556565	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.905C>T; p.S302F; 2:74556573-74556573	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1243C>T; p.R415W; 2:74556911-74556911	ovary	other; neoplasm	Substitution - Missense
c.426G>T; p.E142D; 2:74555640-74555640	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1177G>T; p.V393L; 2:74556845-74556845	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.620G>A; p.R207H; 2:74556059-74556059	prostate	carcinoma	Substitution - Missense
c.238_239insC; p.E83fs*1; 2:74555331-74555332	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.643A>G; p.M215V; 2:74556311-74556311	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.354C>T; p.A118A; 2:74555447-74555447	skin	malignant_melanoma	Substitution - coding silent
c.678A>G; p.S226S; 2:74556346-74556346	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1255C>T; p.P419S; 2:74556923-74556923	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1379G>T; p.S460I; 2:74557047-74557047	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.555C>G; p.L185L; 2:74555994-74555994	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.493G>A; p.A165T; 2:74555932-74555932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.971C>G; p.A324G; 2:74556639-74556639	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.906C>T; p.S302S; 2:74556574-74556574	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1200C>T; p.L400L; 2:74556868-74556868	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1240C>T; p.P414S; 2:74556908-74556908	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.776G>A; p.G259E; 2:74556444-74556444	skin; neck	malignant_melanoma	Substitution - Missense
c.1065C>T; p.D355D; 2:74556733-74556733	skin	malignant_melanoma	Substitution - coding silent
c.1000A>C; p.K334Q; 2:74556668-74556668	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1124G>T; p.G375V; 2:74556792-74556792	liver	carcinoma	Substitution - Missense
c.845C>T; p.P282L; 2:74556513-74556513	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1104G>T; p.L368L; 2:74556772-74556772	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.28_29insT; p.L12fs*33; 2:74554782-74554783	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1445G>A; p.482; 2:74557113-74557113	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.947C>G; p.S316*; 2:74556615-74556615	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation