lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1634
Symbol	DCN
Synonymous	CSCD\|DSPG2\|PG40\|PGII\|PGS2\|SLRR1B
Full name	decorin
Gene description	PG-S2\|bone proteoglycan II\|decorin proteoglycan\|dermatan sulphate proteoglycans II\|proteoglycan core protein\|small leucine-rich protein 1B
Cytoband	12q21.33
Gene type	protein-coding
Synonymous	MIM:125255; HGNC:HGNC:2705; Ensembl:ENSG00000011465; HPRD:00501

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.661C>T; p.P221S; 12:91153181-91153181	skin	malignant_melanoma	Substitution - Missense
c.661C>T; p.P221S; 12:91153181-91153181	skin	malignant_melanoma	Substitution - Missense
c.2T>C; p.M1T; 12:91178551-91178551	skin; arm	malignant_melanoma	Substitution - Missense
c.296G>A; p.G99E; 12:91164633-91164633	skin	malignant_melanoma	Substitution - Missense
c.1066G>A; p.G356R; 12:91146072-91146072	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1066G>A; p.G356R; 12:91146072-91146072	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.616C>T; p.R206C; 12:91157111-91157111	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.46G>A; p.A16T; 12:91178507-91178507	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.593G>A; p.G198E; 12:91157134-91157134	skin	malignant_melanoma	Substitution - Missense
c.699C>T; p.I233I; 12:91153143-91153143	skin	malignant_melanoma	Substitution - coding silent
c.673G>A; p.E225K; 12:91153169-91153169	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.447C>T; p.P149P; 12:91158387-91158387	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.442_443insA; p.M148fs*12; 12:91158391-91158392	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.486C>T; p.I162I; 12:91158348-91158348	skin	malignant_melanoma	Substitution - coding silent
c.532G>A; p.V178I; 12:91158302-91158302	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.623C>T; p.A208V; 12:91157104-91157104	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.765C>A; p.N255K; 12:91151774-91151774	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.653-2A>G; p.?; 12:91153191-91153191	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.49G>A; p.G17R; 12:91178504-91178504	skin	malignant_melanoma	Substitution - Missense
c.420G>T; p.Q140H; 12:91158414-91158414	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.283G>A; p.E95K; 12:91164646-91164646	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.283G>A; p.E95K; 12:91164646-91164646	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.283G>A; p.E95K; 12:91164646-91164646	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.283G>A; p.E95K; 12:91164646-91164646	skin	malignant_melanoma	Substitution - Missense
c.283G>A; p.E95K; 12:91164646-91164646	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.283G>A; p.E95K; 12:91164646-91164646	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.195C>T; p.V65V; 12:91178358-91178358	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.693C>T; p.N231N; 12:91153149-91153149	central_nervous_system; brain	glioma	Substitution - coding silent
c.138C>T; p.F46F; 12:91178415-91178415	skin	malignant_melanoma	Substitution - coding silent
c.923G>C; p.G308A; 12:91146215-91146215	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.449A>C; p.K150T; 12:91158385-91158385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.497G>A; p.R166Q; 12:91158337-91158337	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.29T>C; p.L10P; 12:91178524-91178524	skin	malignant_melanoma	Substitution - Missense
c.127G>T; p.D43Y; 12:91178426-91178426	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.205G>A; p.D69N; 12:91178348-91178348	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.860G>A; p.G287E; 12:91151679-91151679	skin	malignant_melanoma	Substitution - Missense
c.541C>A; p.L181M; 12:91157186-91157186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.397C>T; p.R133*; 12:91158437-91158437	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.397C>T; p.R133*; 12:91158437-91158437	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.1048C>T; p.R350C; 12:91146090-91146090	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.630C>A; p.T210T; 12:91157097-91157097	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.641G>A; p.S214N; 12:91157086-91157086	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.974C>T; p.S325L; 12:91146164-91146164	skin	malignant_melanoma	Substitution - Missense
c.244G>C; p.D82H; 12:91164685-91164685	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.612C>T; p.Y204Y; 12:91157115-91157115	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011G>A; p.W337*; 12:91146127-91146127	skin	malignant_melanoma	Substitution - Nonsense
c.1003C>T; p.Q335*; 12:91146135-91146135	skin	malignant_melanoma	Substitution - Nonsense
c.671C>T; p.T224M; 12:91153171-91153171	central_nervous_system; brain	glioma	Substitution - Missense
c.671C>T; p.T224M; 12:91153171-91153171	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.671C>T; p.T224M; 12:91153171-91153171	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.514G>A; p.G172R; 12:91158320-91158320	skin	malignant_melanoma	Substitution - Missense
c.324+1G>T; p.?; 12:91164604-91164604	lung	carcinoma; adenocarcinoma	Unknown
c.427G>A; p.E143K; 12:91158407-91158407	skin	malignant_melanoma	Substitution - Missense
c.901A>G; p.N301D; 12:91146237-91146237	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1032C>G; p.F344L; 12:91146106-91146106	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1032C>G; p.F344L; 12:91146106-91146106	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1029C>T; p.T343T; 12:91146109-91146109	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1007A>T; p.Y336F; 12:91146131-91146131	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.399A>G; p.R133R; 12:91158435-91158435	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.399A>G; p.R133R; 12:91158435-91158435	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.399A>G; p.R133R; 12:91158435-91158435	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.882C>T; p.I294I; 12:91151657-91151657	skin	malignant_melanoma	Substitution - coding silent
c.187C>T; p.R63*; 12:91178366-91178366	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.426G>T; p.K142N; 12:91158408-91158408	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.597G>T; p.M199I; 12:91157130-91157130	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3G>A; p.M1I; 12:91178550-91178550	skin	malignant_melanoma	Substitution - Missense
c.878A>G; p.Y293C; 12:91151661-91151661	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.606C>A; p.L202L; 12:91157121-91157121	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.912C>T; p.I304I; 12:91146226-91146226	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.131G>A; p.R44H; 12:91178422-91178422	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.706G>T; p.V236F; 12:91153136-91153136	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.706G>T; p.V236F; 12:91153136-91153136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.912C>A; p.I304I; 12:91146226-91146226	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.640A>T; p.S214C; 12:91157087-91157087	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.650A>G; p.Q217R; 12:91157077-91157077	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.650A>G; p.Q217R; 12:91157077-91157077	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1032C>T; p.F344F; 12:91146106-91146106	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.466C>T; p.R156C; 12:91158368-91158368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1048C>A; p.R350S; 12:91146090-91146090	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.322C>T; p.H108Y; 12:91164607-91164607	skin	malignant_melanoma	Substitution - Missense
c.24_26delTCT; p.L10delL; 12:91178527-91178529	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.265C>T; p.Q89*; 12:91164664-91164664	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.833A>G; p.N278S; 12:91151706-91151706	skin	malignant_melanoma	Substitution - Missense
c.76G>T; p.D26Y; 12:91178477-91178477	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.288C>A; p.I96I; 12:91164641-91164641	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1045G>A; p.V349M; 12:91146093-91146093	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.860G>T; p.G287V; 12:91151679-91151679	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.52C>T; p.P18S; 12:91178501-91178501	skin	malignant_melanoma	Substitution - Missense
c.1077_1080delGTAA; p.K359fs?; 12:91146058-91146061	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.665C>T; p.S222F; 12:91153177-91153177	skin	malignant_melanoma	Substitution - Missense
c.1049G>A; p.R350H; 12:91146089-91146089	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.530T>C; p.I177T; 12:91158304-91158304	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.530T>C; p.I177T; 12:91158304-91158304	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.731T>C; p.L244P; 12:91153111-91153111	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.569G>A; p.G190E; 12:91157158-91157158	breast	carcinoma	Substitution - Missense
c.135C>G; p.D45E; 12:91178418-91178418	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.425A>C; p.K142T; 12:91158409-91158409	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.176A>G; p.Q59R; 12:91178377-91178377	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.502G>A; p.V168I; 12:91158332-91158332	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.523C>T; p.Q175*; 12:91158311-91158311	skin	malignant_melanoma	Substitution - Nonsense
c.121C>T; p.P41S; 12:91178432-91178432	skin	malignant_melanoma	Substitution - Missense
c.662C>A; p.P221H; 12:91153180-91153180	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.325G>A; p.A109T; 12:91158509-91158509	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.325G>A; p.A109T; 12:91158509-91158509	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.51A>C; p.G17G; 12:91178502-91178502	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.852A>G; p.V284V; 12:91151687-91151687	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.912C>G; p.I304M; 12:91146226-91146226	breast	carcinoma	Substitution - Missense
c.534C>T; p.V178V; 12:91158300-91158300	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.659C>A; p.P220H; 12:91153183-91153183	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.430T>A; p.L144M; 12:91158404-91158404	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.149T>A; p.L50Q; 12:91178404-91178404	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.300C>A; p.D100E; 12:91164629-91164629	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.283G>T; p.E95*; 12:91164646-91164646	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation