lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1544
Symbol	CYP1A2
Synonymous	CP12\|P3-450\|P450(PA)
Full name	cytochrome P450, family 1, subfamily A, polypeptide 2
Gene description	CYPIA2\|P450 form 4\|aryl hydrocarbon hydroxylase\|cytochrome P(3)450\|cytochrome P450 1A2\|cytochrome P450 4\|cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2\|cytochrome P450-P3\|dioxin-inducible P3-450\|flavoprotein-linked monooxygenase
Cytoband	15q24.1
Gene type	protein-coding
Synonymous	MIM:124060; HGNC:HGNC:2596; Ensembl:ENSG00000140505; HPRD:00489; Vega:OTTHUMG00000172901

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.851C>T; p.T284M; 15:74751208-74751208	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1450C>A; p.P484T; 15:74754987-74754987	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.615C>T; p.F205F; 15:74750353-74750353	skin	malignant_melanoma	Substitution - coding silent
c.1457G>T; p.G486V; 15:74754994-74754994	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.831+8C>A; p.?; 15:74750577-74750577	stomach	carcinoma; diffuse_adenocarcinoma	Unknown
c.1215C>T; p.C405C; 15:74753232-74753232	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1503C>T; p.H501H; 15:74755040-74755040	liver	carcinoma	Substitution - coding silent
c.1503C>T; p.H501H; 15:74755040-74755040	liver	carcinoma	Substitution - coding silent
c.1064G>A; p.R355Q; 15:74752145-74752145	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.302A>G; p.Q101R; 15:74750040-74750040	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.151C>G; p.L51V; 15:74749889-74749889	breast	carcinoma	Substitution - Missense
c.826G>A; p.D276N; 15:74750564-74750564	meninges	meningioma; secretory	Substitution - Missense
c.126A>C; p.P42P; 15:74749864-74749864	breast	carcinoma	Substitution - coding silent
c.727C>T; p.R243C; 15:74750465-74750465	skin	malignant_melanoma	Substitution - Missense
c.251C>T; p.P84L; 15:74749989-74749989	skin	malignant_melanoma	Substitution - Missense
c.464C>T; p.S155F; 15:74750202-74750202	skin	malignant_melanoma	Substitution - Missense
c.881G>A; p.G294E; 15:74751238-74751238	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1240G>A; p.V414I; 15:74753257-74753257	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.321C>A; p.G107G; 15:74750059-74750059	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.501G>A; p.K167K; 15:74750239-74750239	skin	malignant_melanoma	Substitution - coding silent
c.501G>A; p.K167K; 15:74750239-74750239	skin	malignant_melanoma	Substitution - coding silent
c.60C>T; p.I20I; 15:74749798-74749798	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.348C>T; p.L116L; 15:74750086-74750086	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.249G>A; p.T83T; 15:74749987-74749987	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.249G>A; p.T83T; 15:74749987-74749987	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.727C>G; p.R243G; 15:74750465-74750465	urinary_tract; bladder	carcinoma	Substitution - Missense
c.306C>T; p.G102G; 15:74750044-74750044	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.216C>T; p.Y72Y; 15:74749954-74749954	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.323G>A; p.R108Q; 15:74750061-74750061	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1023G>A; p.R341R; 15:74751835-74751835	skin	malignant_melanoma	Substitution - coding silent
c.1023G>A; p.R341R; 15:74751835-74751835	skin	malignant_melanoma	Substitution - coding silent
c.1023G>A; p.R341R; 15:74751835-74751835	skin	malignant_melanoma	Substitution - coding silent
c.211C>T; p.R71C; 15:74749949-74749949	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1166+2T>C; p.?; 15:74752249-74752249	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.393G>A; p.P131P; 15:74750131-74750131	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1455G>A; p.P485P; 15:74754992-74754992	pancreas	carcinoma	Substitution - coding silent
c.1455G>A; p.P485P; 15:74754992-74754992	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.884C>T; p.P295L; 15:74751241-74751241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.887G>C; p.R296T; 15:74751244-74751244	urinary_tract; bladder	carcinoma	Substitution - Missense
c.88G>T; p.G30C; 15:74749826-74749826	skin	malignant_melanoma	Substitution - Missense
c.1068G>A; p.R356R; 15:74752149-74752149	skin	malignant_melanoma	Substitution - coding silent
c.209_210AG>CC; p.Q70>?; 15:74749947-74749948	large_intestine; rectum	carcinoma; adenocarcinoma	Complex
c.407G>A; p.R136H; 15:74750145-74750145	prostate	carcinoma	Substitution - Missense
c.258G>A; p.L86L; 15:74749996-74749996	thyroid	carcinoma	Substitution - coding silent
c.1221C>A; p.V407V; 15:74753238-74753238	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.407G>A; p.R136H; 15:74750145-74750145	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.236G>T; p.R79L; 15:74749974-74749974	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.696C>T; p.S232S; 15:74750434-74750434	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.696C>T; p.S232S; 15:74750434-74750434	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1344G>C; p.M448I; 15:74754881-74754881	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.872G>A; p.S291N; 15:74751229-74751229	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.774G>A; p.Q258Q; 15:74750512-74750512	skin	malignant_melanoma	Substitution - coding silent
c.253G>A; p.V85M; 15:74749991-74749991	central_nervous_system; brain	glioma	Substitution - Missense
c.1413C>T; p.F471F; 15:74754950-74754950	skin	malignant_melanoma	Substitution - coding silent
c.740A>C; p.N247T; 15:74750478-74750478	pancreas	carcinoma	Substitution - Missense
c.495G>C; p.V165V; 15:74750233-74750233	breast	carcinoma	Substitution - coding silent
c.1159C>T; p.P387S; 15:74752240-74752240	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.289G>A; p.A97T; 15:74750027-74750027	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.248C>T; p.T83M; 15:74749986-74749986	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.609G>A; p.M203I; 15:74750347-74750347	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.115C>G; p.L39V; 15:74749853-74749853	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.115C>G; p.L39V; 15:74749853-74749853	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.448G>A; p.A150T; 15:74750186-74750186	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1506C>T; p.A502A; 15:74755043-74755043	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1166G>T; p.S389I; 15:74752247-74752247	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.299G>A; p.R100Q; 15:74750037-74750037	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1116C>T; p.I372I; 15:74752197-74752197	skin	malignant_melanoma	Substitution - coding silent
c.1398G>A; p.W466*; 15:74754935-74754935	skin	malignant_melanoma	Substitution - Nonsense
c.1253+1G>A; p.?; 15:74753271-74753271	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.269G>A; p.R90H; 15:74750007-74750007	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1468G>A; p.D490N; 15:74755005-74755005	skin	malignant_melanoma	Substitution - Missense
c.1125C>T; p.T375T; 15:74752206-74752206	skin	malignant_melanoma	Substitution - coding silent
c.1125C>T; p.T375T; 15:74752206-74752206	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1489C>T; p.L497L; 15:74755026-74755026	skin	malignant_melanoma	Substitution - coding silent
c.185A>C; p.H62P; 15:74749923-74749923	breast	carcinoma	Substitution - Missense
c.927C>A; p.N309K; 15:74751284-74751284	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1305C>T; p.A435A; 15:74754842-74754842	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1498A>G; p.K500E; 15:74755035-74755035	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1528C>T; p.R510W; 15:74755065-74755065	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1177G>A; p.D393N; 15:74753194-74753194	skin	malignant_melanoma	Substitution - Missense
c.1010C>A; p.P337H; 15:74751822-74751822	large_intestine; colon	carcinoma	Substitution - Missense
c.1447G>A; p.V483M; 15:74754984-74754984	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1447G>A; p.V483M; 15:74754984-74754984	breast	carcinoma	Substitution - Missense
c.1447G>A; p.V483M; 15:74754984-74754984	breast	carcinoma	Substitution - Missense
c.1447G>A; p.V483M; 15:74754984-74754984	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.320G>A; p.G107D; 15:74750058-74750058	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.857C>A; p.A286D; 15:74751214-74751214	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.844G>A; p.D282N; 15:74751201-74751201	skin	malignant_melanoma	Substitution - Missense
c.547C>T; p.P183S; 15:74750285-74750285	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1527G>A; p.A509A; 15:74755064-74755064	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1093C>T; p.L365L; 15:74752174-74752174	skin	malignant_melanoma	Substitution - coding silent
c.1469A>G; p.D490G; 15:74755006-74755006	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.362A>G; p.Q121R; 15:74750100-74750100	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.804C>T; p.V268V; 15:74750542-74750542	skin	malignant_melanoma	Substitution - coding silent
c.1452G>A; p.P484P; 15:74754989-74754989	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1452G>A; p.P484P; 15:74754989-74754989	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.100C>T; p.R34W; 15:74749838-74749838	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.156G>A; p.G52G; 15:74749894-74749894	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.100C>T; p.R34W; 15:74749838-74749838	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1452G>A; p.P484P; 15:74754989-74754989	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.980C>T; p.S327F; 15:74751792-74751792	skin	malignant_melanoma	Substitution - Missense
c.1432C>A; p.Q478K; 15:74754969-74754969	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.491A>G; p.H164R; 15:74750229-74750229	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1452G>A; p.P484P; 15:74754989-74754989	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1452G>A; p.P484P; 15:74754989-74754989	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1010C>T; p.P337L; 15:74751822-74751822	skin	malignant_melanoma	Substitution - Missense
c.1295_1296insC; p.L433fs*9; 15:74754832-74754833	skin	malignant_melanoma	Insertion - Frameshift
c.663G>T; p.K221N; 15:74750401-74750401	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.245C>T; p.S82F; 15:74749983-74749983	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.273G>A; p.L91L; 15:74750011-74750011	skin	malignant_melanoma	Substitution - coding silent
c.1310G>A; p.G437D; 15:74754847-74754847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.802G>T; p.V268F; 15:74750540-74750540	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.235C>T; p.R79C; 15:74749973-74749973	central_nervous_system; brain	glioma	Substitution - Missense
c.235C>T; p.R79C; 15:74749973-74749973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1081G>A; p.D361N; 15:74752162-74752162	oesophagus	carcinoma	Substitution - Missense
c.363G>A; p.Q121Q; 15:74750101-74750101	breast	carcinoma; ductal_carcinoma	Substitution - coding silent
c.363G>A; p.Q121Q; 15:74750101-74750101	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.1534C>T; p.R512C; 15:74755071-74755071	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1066C>T; p.R356W; 15:74752147-74752147	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1264G>A; p.E422K; 15:74754801-74754801	skin	malignant_melanoma	Substitution - Missense
c.1066C>T; p.R356W; 15:74752147-74752147	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.724C>T; p.L242F; 15:74750462-74750462	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.699G>A; p.G233G; 15:74750437-74750437	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.906C>G; p.I302M; 15:74751263-74751263	thyroid	carcinoma	Substitution - Missense
c.267C>G; p.S89R; 15:74750005-74750005	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.409C>T; p.R137W; 15:74750147-74750147	skin	malignant_melanoma	Substitution - Missense
c.409C>T; p.R137W; 15:74750147-74750147	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.183G>A; p.P61P; 15:74749921-74749921	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.933C>A; p.V311V; 15:74751290-74751290	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.310G>A; p.D104N; 15:74750048-74750048	skin	malignant_melanoma	Substitution - Missense
c.310G>A; p.D104N; 15:74750048-74750048	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1198T>C; p.Y400H; 15:74753215-74753215	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1378G>A; p.G460R; 15:74754915-74754915	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1521C>T; p.V507V; 15:74755058-74755058	skin	malignant_melanoma	Substitution - coding silent
c.1463A>T; p.K488I; 15:74755000-74755000	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1291C>T; p.R431W; 15:74754828-74754828	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.418G>T; p.A140S; 15:74750156-74750156	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.678C>T; p.F226F; 15:74750416-74750416	skin	malignant_melanoma	Substitution - coding silent
c.236G>A; p.R79H; 15:74749974-74749974	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.678C>T; p.F226F; 15:74750416-74750416	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.678C>T; p.F226F; 15:74750416-74750416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1096C>T; p.P366S; 15:74752177-74752177	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1504G>A; p.A502T; 15:74755041-74755041	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.155G>A; p.G52E; 15:74749893-74749893	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1226T>C; p.V409A; 15:74753243-74753243	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.288G>A; p.Q96Q; 15:74750026-74750026	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.268C>T; p.R90C; 15:74750006-74750006	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation