Cancer metastasis database

Annotation category 5

Gene information

Gene ID 1520
Symbol

CTSS

Synonymous

-

Full name

cathepsin S

Gene description

-

Cytoband

1q21

Gene type

protein-coding

Synonymous

MIM:116845; HGNC:HGNC:2545; Ensembl:ENSG00000163131; HPRD:00292; Vega:OTTHUMG00000035010

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.615C>T; p.P205P; 1:150751793-150751793

 skinmalignant_melanomaSubstitution - coding silent

c.761C>T; p.A254V; 1:150750038-150750038

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.46G>A; p.A16T; 1:150764718-150764718

 skin; trunkmalignant_melanomaSubstitution - Missense

c.552C>T; p.F184F; 1:150751856-150751856

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.770C>T; p.P257L; 1:150750029-150750029

 skinmalignant_melanomaSubstitution - Missense

c.683C>T; p.T228I; 1:150750116-150750116

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.273G>C; p.L91F; 1:150755127-150755127

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.490G>A; p.A164T; 1:150751918-150751918

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.631C>G; p.Q211E; 1:150750168-150750168

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.445G>A; p.E149K; 1:150751963-150751963

 skinmalignant_melanomaSubstitution - Missense

c.282C>T; p.S94S; 1:150755118-150755118

 skinmalignant_melanomaSubstitution - coding silent

c.369G>C; p.E123D; 1:150755031-150755031

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.561G>A; p.T187T; 1:150751847-150751847

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.971G>A; p.S324N; 1:150733071-150733071

 livercarcinomaSubstitution - Missense

c.971G>A; p.S324N; 1:150733071-150733071

 livercarcinomaSubstitution - Missense

c.337C>T; p.R113W; 1:150755063-150755063

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.470G>A; p.G157E; 1:150751938-150751938

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.337C>T; p.R113W; 1:150755063-150755063

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.337C>T; p.R113W; 1:150755063-150755063

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.337C>T; p.R113W; 1:150755063-150755063

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.219C>T; p.Y73Y; 1:150757888-150757888

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.571T>C; p.Y191H; 1:150751837-150751837

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.678G>T; p.K226N; 1:150750121-150750121

 breastcarcinomaSubstitution - Missense

c.988G>T; p.E330*; 1:150733054-150733054

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.579T>C; p.I193I; 1:150751829-150751829

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.780C>T; p.F260F; 1:150750019-150750019

 skinmalignant_melanomaSubstitution - coding silent

c.292C>T; p.P98S; 1:150755108-150755108

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.308G>A; p.R103K; 1:150755092-150755092

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.865A>T; p.N289Y; 1:150747808-150747808

 central_nervous_system; spinal_cordglioma; ependymomaSubstitution - Missense

c.121G>A; p.E41K; 1:150764643-150764643

 skinmalignant_melanomaSubstitution - Missense

c.765T>C; p.R255R; 1:150750034-150750034

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.143G>A; p.R48Q; 1:150757964-150757964

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.527G>A; p.G176E; 1:150751881-150751881

 skinmalignant_melanomaSubstitution - Missense

c.835G>A; p.G279S; 1:150747838-150747838

 skinmalignant_melanomaSubstitution - Missense

c.269C>A; p.S90Y; 1:150755131-150755131

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.416G>T; p.C139F; 1:150751992-150751992

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.706G>C; p.D236H; 1:150750093-150750093

 breastcarcinomaSubstitution - Missense

c.595G>A; p.D199N; 1:150751813-150751813

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.456G>A; p.L152L; 1:150751952-150751952

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.325T>G; p.S109A; 1:150755075-150755075

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.742G>A; p.V248M; 1:150750057-150750057

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.142C>T; p.R48*; 1:150757965-150757965

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.921A>T; p.E307D; 1:150733121-150733121

 ovaryother; neoplasmSubstitution - Missense

c.394T>G; p.Y132D; 1:150755006-150755006

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.394T>G; p.Y132D; 1:150755006-150755006

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.601G>C; p.D201H; 1:150751807-150751807

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.65C>T; p.P22L; 1:150764699-150764699

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.491C>T; p.A164V; 1:150751917-150751917

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.116A>G; p.Y39C; 1:150764648-150764648

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.760G>A; p.A254T; 1:150750039-150750039

 skinmalignant_melanomaSubstitution - Missense

c.441C>T; p.A147A; 1:150751967-150751967

 skinmalignant_melanomaSubstitution - coding silent

c.269C>T; p.S90F; 1:150755131-150755131

 skinmalignant_melanomaSubstitution - Missense

c.383C>T; p.T128I; 1:150755017-150755017

 skinmalignant_melanomaSubstitution - Missense

c.658C>T; p.R220C; 1:150750141-150750141

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.740C>T; p.P247L; 1:150750059-150750059

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.868G>T; p.G290W; 1:150747805-150747805

 skinmalignant_melanomaSubstitution - Missense

c.562G>A; p.A188T; 1:150751846-150751846

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.740C>T; p.P247L; 1:150750059-150750059

 livercarcinomaSubstitution - Missense

c.7C>T; p.R3W; 1:150764757-150764757

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.553A>G; p.M185V; 1:150751855-150751855

 ovaryother; neoplasmSubstitution - Missense

c.553A>G; p.M185V; 1:150751855-150751855

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.766C>T; p.H256Y; 1:150750033-150750033

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.862C>G; p.L288V; 1:150747811-150747811

 central_nervous_system; spinal_cordglioma; ependymomaSubstitution - Missense

c.931C>T; p.R311W; 1:150733111-150733111

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.25T>G; p.L9V; 1:150764739-150764739

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.242G>A; p.G81E; 1:150757865-150757865

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.866A>G; p.N289S; 1:150747807-150747807

 central_nervous_system; spinal_cordglioma; ependymomaSubstitution - Missense