lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	149233
Symbol	IL23R
Synonymous	-
Full name	interleukin 23 receptor
Gene description	IL-23 receptor\|interleukin-23 receptor
Cytoband	1p31.3
Gene type	protein-coding
Synonymous	MIM:607562; HGNC:HGNC:19100; Ensembl:ENSG00000162594; HPRD:16249; Vega:OTTHUMG00000009092

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1212A>C; p.K404N; 1:67255900-67255900	breast	carcinoma	Substitution - Missense
c.1886delA; p.K629fs?; 1:67259124-67259124	ovary	carcinoma	Deletion - Frameshift
c.505G>A; p.E169K; 1:67200750-67200750	skin	malignant_melanoma	Substitution - Missense
c.1243A>C; p.N415H; 1:67258481-67258481	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1567A>T; p.R523W; 1:67258805-67258805	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.724T>C; p.W242R; 1:67206981-67206981	central_nervous_system; brain	glioma	Substitution - Missense
c.1272T>G; p.S424R; 1:67258510-67258510	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1874C>T; p.S625L; 1:67259112-67259112	skin	malignant_melanoma	Substitution - Missense
c.1083C>G; p.I361M; 1:67240216-67240216	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1112C>A; p.S371Y; 1:67240245-67240245	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.554C>G; p.S185*; 1:67200799-67200799	breast	carcinoma	Substitution - Nonsense
c.841G>T; p.E281*; 1:67219616-67219616	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1281C>T; p.V427V; 1:67258519-67258519	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1281C>T; p.V427V; 1:67258519-67258519	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1281C>T; p.V427V; 1:67258519-67258519	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1202C>T; p.P401L; 1:67255890-67255890	skin	malignant_melanoma	Substitution - Missense
c.1069T>C; p.L357L; 1:67240202-67240202	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1069T>C; p.L357L; 1:67240202-67240202	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.806A>G; p.E269G; 1:67219581-67219581	stomach	adenocarcinoma	Substitution - Missense
c.1564C>T; p.P522S; 1:67258802-67258802	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.429T>C; p.T143T; 1:67182897-67182897	ovary	other; neoplasm	Substitution - coding silent
c.362C>A; p.S121Y; 1:67169633-67169633	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1013T>C; p.V338A; 1:67236770-67236770	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.519T>C; p.Y173Y; 1:67200764-67200764	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.421A>C; p.N141H; 1:67182889-67182889	breast	carcinoma	Substitution - Missense
c.564T>C; p.G188G; 1:67200809-67200809	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1271G>A; p.S424N; 1:67258509-67258509	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1820C>A; p.S607Y; 1:67259058-67259058	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.570G>A; p.K190K; 1:67200815-67200815	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.639C>A; p.H213Q; 1:67200884-67200884	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.119C>A; p.T40K; 1:67169390-67169390	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.333G>A; p.E111E; 1:67169604-67169604	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.382C>T; p.P128S; 1:67182850-67182850	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1545C>A; p.S515S; 1:67258783-67258783	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.257G>A; p.R86Q; 1:67169528-67169528	pancreas	carcinoma	Substitution - Missense
c.257G>A; p.R86Q; 1:67169528-67169528	pancreas	carcinoma	Substitution - Missense
c.257G>A; p.R86Q; 1:67169528-67169528	pancreas	carcinoma	Substitution - Missense
c.1001C>A; p.S334Y; 1:67236758-67236758	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.221G>A; p.R74K; 1:67169492-67169492	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.750G>T; p.K250N; 1:67207007-67207007	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.677C>G; p.S226C; 1:67206934-67206934	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1800C>T; p.I600I; 1:67259038-67259038	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.508G>A; p.E170K; 1:67200753-67200753	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1695C>A; p.N565K; 1:67258933-67258933	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1777G>A; p.E593K; 1:67259015-67259015	skin	malignant_melanoma	Substitution - Missense
c.486G>T; p.V162V; 1:67182954-67182954	liver	carcinoma	Substitution - coding silent
c.486G>T; p.V162V; 1:67182954-67182954	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.226C>T; p.Q76*; 1:67169497-67169497	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1566C>A; p.P522P; 1:67258804-67258804	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1377G>A; p.E459E; 1:67258615-67258615	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.287A>G; p.H96R; 1:67169558-67169558	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1642G>T; p.E548*; 1:67258880-67258880	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1642G>T; p.E548*; 1:67258880-67258880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1442A>C; p.N481T; 1:67258680-67258680	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.831G>T; p.V277V; 1:67219606-67219606	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.754T>C; p.S252P; 1:67207011-67207011	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1239G>C; p.Q413H; 1:67255927-67255927	ovary	carcinoma	Substitution - Missense
c.1393C>A; p.Q465K; 1:67258631-67258631	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.963G>A; p.Q321Q; 1:67236720-67236720	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1255A>T; p.M419L; 1:67258493-67258493	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1562A>T; p.N521I; 1:67258800-67258800	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.685G>A; p.E229K; 1:67206942-67206942	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1692A>C; p.Q564H; 1:67258930-67258930	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.631C>A; p.Q211K; 1:67200876-67200876	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.432C>A; p.C144*; 1:67182900-67182900	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.193C>A; p.H65N; 1:67169464-67169464	liver	carcinoma	Substitution - Missense
c.1653C>T; p.L551L; 1:67258891-67258891	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1091C>G; p.A364G; 1:67240224-67240224	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.237G>A; p.R79R; 1:67169508-67169508	skin	malignant_melanoma	Substitution - coding silent
c.1091C>G; p.A364G; 1:67240224-67240224	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.371C>T; p.P124L; 1:67182839-67182839	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.371C>T; p.P124L; 1:67182839-67182839	skin	malignant_melanoma	Substitution - Missense
c.371C>T; p.P124L; 1:67182839-67182839	liver	carcinoma	Substitution - Missense
c.1142G>A; p.R381Q; 1:67240275-67240275	soft_tissue; striated_muscle	rhabdomyosarcoma; alveolar	Substitution - Missense
c.371C>T; p.P124L; 1:67182839-67182839	liver	carcinoma	Substitution - Missense
c.1341T>C; p.P447P; 1:67258579-67258579	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1148+1G>A; p.?; 1:67240282-67240282	thyroid	carcinoma	Unknown
c.814A>G; p.T272A; 1:67219589-67219589	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.301T>C; p.C101R; 1:67169572-67169572	skin	malignant_melanoma	Substitution - Missense
c.263G>T; p.W88L; 1:67169534-67169534	breast	carcinoma	Substitution - Missense
c.144C>A; p.I48I; 1:67169415-67169415	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.601G>A; p.A201T; 1:67200846-67200846	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.601G>A; p.A201T; 1:67200846-67200846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.601G>A; p.A201T; 1:67200846-67200846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1311A>G; p.I437M; 1:67258549-67258549	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1311A>G; p.I437M; 1:67258549-67258549	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.601G>A; p.A201T; 1:67200846-67200846	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1768C>A; p.L590I; 1:67259006-67259006	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1654A>G; p.I552V; 1:67258892-67258892	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.95G>T; p.G32V; 1:67169366-67169366	ovary	other; neoplasm	Substitution - Missense
c.89G>T; p.C30F; 1:67169360-67169360	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.492-2A>C; p.?; 1:67200735-67200735	urinary_tract; bladder	carcinoma	Unknown
c.66T>C; p.H22H; 1:67168186-67168186	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1677T>G; p.S559R; 1:67258915-67258915	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.755C>A; p.S252Y; 1:67207012-67207012	kidney	other; neoplasm	Substitution - Missense
c.1627A>G; p.T543A; 1:67258865-67258865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.765G>A; p.M255I; 1:67207022-67207022	urinary_tract; bladder	carcinoma	Substitution - Missense
c.732T>C; p.S244S; 1:67206989-67206989	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.375A>T; p.P125P; 1:67182843-67182843	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1269C>T; p.S423S; 1:67258507-67258507	liver	carcinoma	Substitution - coding silent
c.1391C>T; p.P464L; 1:67258629-67258629	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.236G>A; p.R79K; 1:67169507-67169507	skin	malignant_melanoma	Substitution - Missense
c.1269C>T; p.S423S; 1:67258507-67258507	liver	carcinoma	Substitution - coding silent
c.1400C>T; p.S467L; 1:67258638-67258638	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1400C>T; p.S467L; 1:67258638-67258638	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.352G>T; p.D118Y; 1:67169623-67169623	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1480G>A; p.E494K; 1:67258718-67258718	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1460A>G; p.Q487R; 1:67258698-67258698	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.949G>A; p.E317K; 1:67219724-67219724	skin	malignant_melanoma	Substitution - Missense
c.1019C>T; p.S340F; 1:67236776-67236776	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.611T>C; p.M204T; 1:67200856-67200856	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.227A>G; p.Q76R; 1:67169498-67169498	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1189T>C; p.Y397H; 1:67255877-67255877	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.823A>G; p.T275A; 1:67219598-67219598	liver	carcinoma	Substitution - Missense
c.1708G>A; p.E570K; 1:67258946-67258946	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.823A>G; p.T275A; 1:67219598-67219598	liver	carcinoma	Substitution - Missense
c.162A>T; p.A54A; 1:67169433-67169433	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.445G>A; p.G149R; 1:67182913-67182913	kidney	other; neoplasm	Substitution - Missense
c.1824T>C; p.I608I; 1:67259062-67259062	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.539A>C; p.N180T; 1:67200784-67200784	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.805G>T; p.E269*; 1:67219580-67219580	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1262A>G; p.N421S; 1:67258500-67258500	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1436A>G; p.D479G; 1:67258674-67258674	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1238A>T; p.Q413L; 1:67255926-67255926	breast	carcinoma	Substitution - Missense
c.9G>T; p.Q3H; 1:67168129-67168129	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation