lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1401
Symbol	CRP
Synonymous	PTX1
Full name	C-reactive protein, pentraxin-related
Gene description	C-reactive protein\|pentraxin 1
Cytoband	1q23.2
Gene type	protein-coding
Synonymous	MIM:123260; HGNC:HGNC:2367; Ensembl:ENSG00000132693; HPRD:00422; Vega:OTTHUMG00000035344

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.594C>T; p.F198F; 1:159713606-159713606	thyroid	carcinoma	Substitution - coding silent
c.263A>G; p.D88G; 1:159713937-159713937	breast	carcinoma	Substitution - Missense
c.135G>T; p.T45T; 1:159714065-159714065	breast	carcinoma	Substitution - coding silent
c.456C>T; p.I152I; 1:159713744-159713744	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.456C>T; p.I152I; 1:159713744-159713744	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.449G>T; p.S150I; 1:159713751-159713751	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.420G>T; p.K140N; 1:159713780-159713780	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.640G>A; p.G214S; 1:159713560-159713560	skin	malignant_melanoma	Substitution - Missense
c.586G>T; p.G196W; 1:159713614-159713614	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.483T>A; p.G161G; 1:159713717-159713717	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.238G>A; p.E80K; 1:159713962-159713962	skin	malignant_melanoma	Substitution - Missense
c.157G>C; p.V53L; 1:159714043-159714043	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.344G>A; p.C115Y; 1:159713856-159713856	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.577T>C; p.Y193H; 1:159713623-159713623	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.563A>G; p.E188G; 1:159713637-159713637	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.476C>T; p.S159F; 1:159713724-159713724	skin	malignant_melanoma	Substitution - Missense
c.619G>A; p.A207T; 1:159713581-159713581	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.648G>T; p.V216V; 1:159713552-159713552	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.54C>T; p.G18G; 1:159714432-159714432	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.28T>C; p.L10L; 1:159714458-159714458	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.225G>T; p.K75N; 1:159713975-159713975	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.227G>A; p.R76K; 1:159713973-159713973	skin	malignant_melanoma	Substitution - Missense
c.116C>A; p.S39Y; 1:159714084-159714084	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.334G>A; p.V112I; 1:159713866-159713866	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.217G>A; p.A73T; 1:159713983-159713983	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.283G>A; p.V95M; 1:159713917-159713917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.17_18delGT; p.C6fs*74; 1:159714468-159714469	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.466G>T; p.E156*; 1:159713734-159713734	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.425G>A; p.G142E; 1:159713775-159713775	skin	malignant_melanoma	Substitution - Missense
c.204T>C; p.S68S; 1:159713996-159713996	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.631G>A; p.E211K; 1:159713569-159713569	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.262G>A; p.D88N; 1:159713938-159713938	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.148G>T; p.A50S; 1:159714052-159714052	breast	carcinoma	Substitution - Missense
c.375G>A; p.V125V; 1:159713825-159713825	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.486G>A; p.G162G; 1:159713714-159713714	skin	malignant_melanoma	Substitution - coding silent
c.480C>T; p.F160F; 1:159713720-159713720	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.612C>T; p.N204N; 1:159713588-159713588	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.612C>T; p.N204N; 1:159713588-159713588	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.357G>A; p.E119E; 1:159713843-159713843	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.617G>C; p.R206P; 1:159713583-159713583	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.643G>A; p.E215K; 1:159713557-159713557	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.94G>T; p.E32*; 1:159714106-159714106	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.465G>A; p.Q155Q; 1:159713735-159713735	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.372C>T; p.I124I; 1:159713828-159713828	skin	malignant_melanoma	Substitution - coding silent
c.372C>T; p.I124I; 1:159713828-159713828	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.372C>T; p.I124I; 1:159713828-159713828	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.372C>T; p.I124I; 1:159713828-159713828	skin	malignant_melanoma	Substitution - coding silent
c.372C>T; p.I124I; 1:159713828-159713828	skin	malignant_melanoma	Substitution - coding silent
c.178G>A; p.E60K; 1:159714022-159714022	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.377A>C; p.E126A; 1:159713823-159713823	skin	malignant_melanoma	Substitution - Missense
c.307G>A; p.E103K; 1:159713893-159713893	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.367G>A; p.G123R; 1:159713833-159713833	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.432T>G; p.T144T; 1:159713768-159713768	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.585C>T; p.G195G; 1:159713615-159713615	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.212C>A; p.S71*; 1:159713988-159713988	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.331C>G; p.P111A; 1:159713869-159713869	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.341T>C; p.I114T; 1:159713859-159713859	skin	malignant_melanoma	Substitution - Missense
c.261G>T; p.K87N; 1:159713939-159713939	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.212C>T; p.S71L; 1:159713988-159713988	skin	malignant_melanoma	Substitution - Missense
c.212C>T; p.S71L; 1:159713988-159713988	skin	malignant_melanoma	Substitution - Missense
c.487A>T; p.N163Y; 1:159713713-159713713	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.600T>C; p.P200P; 1:159713600-159713600	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.99G>A; p.S33S; 1:159714101-159714101	pancreas	carcinoma	Substitution - coding silent
c.129G>A; p.P43P; 1:159714071-159714071	liver	carcinoma	Substitution - coding silent
c.129G>A; p.P43P; 1:159714071-159714071	liver	carcinoma	Substitution - coding silent
c.129G>A; p.P43P; 1:159714071-159714071	liver	carcinoma	Substitution - coding silent
c.99G>A; p.S33S; 1:159714101-159714101	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.442G>A; p.E148K; 1:159713758-159713758	skin	malignant_melanoma	Substitution - Missense
c.594C>A; p.F198L; 1:159713606-159713606	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.313C>T; p.P105S; 1:159713887-159713887	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.313C>T; p.P105S; 1:159713887-159713887	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.6G>T; p.E2D; 1:159714480-159714480	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.361G>A; p.A121T; 1:159713839-159713839	thyroid	carcinoma	Substitution - Missense
c.497G>A; p.G166E; 1:159713703-159713703	skin	malignant_melanoma	Substitution - Missense
c.640G>T; p.G214C; 1:159713560-159713560	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.185C>G; p.S62C; 1:159714015-159714015	breast	carcinoma	Substitution - Missense
c.312T>C; p.V104V; 1:159713888-159713888	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.88C>T; p.P30S; 1:159714112-159714112	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.225G>A; p.K75K; 1:159713975-159713975	skin	malignant_melanoma	Substitution - coding silent
c.526A>C; p.N176H; 1:159713674-159713674	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.177G>A; p.T59T; 1:159714023-159714023	pancreas	carcinoma	Substitution - coding silent
c.177G>A; p.T59T; 1:159714023-159714023	pancreas	carcinoma	Substitution - coding silent
c.40T>A; p.S14T; 1:159714446-159714446	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.410A>T; p.K137M; 1:159713790-159713790	skin	malignant_melanoma	Substitution - Missense
c.116C>T; p.S39F; 1:159714084-159714084	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.441A>T; p.A147A; 1:159713759-159713759	thyroid	other; neoplasm	Substitution - coding silent
c.360C>T; p.S120S; 1:159713840-159713840	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.580C>T; p.L194F; 1:159713620-159713620	skin	malignant_melanoma	Substitution - Missense
c.659C>T; p.P220L; 1:159713541-159713541	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.481G>A; p.G161S; 1:159713719-159713719	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.135G>A; p.T45T; 1:159714065-159714065	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - coding silent
c.135G>A; p.T45T; 1:159714065-159714065	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.135G>A; p.T45T; 1:159714065-159714065	skin	malignant_melanoma	Substitution - coding silent
c.135G>A; p.T45T; 1:159714065-159714065	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.135G>A; p.T45T; 1:159714065-159714065	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.562G>A; p.E188K; 1:159713638-159713638	skin	malignant_melanoma	Substitution - Missense
c.472G>T; p.D158Y; 1:159713728-159713728	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.467A>T; p.E156V; 1:159713733-159713733	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.505T>C; p.S169P; 1:159713695-159713695	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.89C>T; p.P30L; 1:159714111-159714111	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.309G>T; p.E103D; 1:159713891-159713891	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.314C>A; p.P105H; 1:159713886-159713886	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation