lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1386
Symbol	ATF2
Synonymous	CRE-BP1\|CREB-2\|CREB2\|HB16\|TREB7
Full name	activating transcription factor 2
Gene description	activating transcription factor 2 splice variant ATF2-var2\|cAMP response element-binding protein CRE-BP1\|cAMP responsive element binding protein 2, formerly\|cAMP-dependent transcription factor ATF-2\|cAMP-responsive element-binding protein 2\|cyclic AMP-dep
Cytoband	2q32
Gene type	protein-coding
Synonymous	MIM:123811; HGNC:HGNC:784; Ensembl:ENSG00000115966; HPRD:00443; Vega:OTTHUMG00000132424

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1148A>T; p.K383I; 2:175093098-175093098	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.133C>A; p.H45N; 2:175121510-175121510	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.318delA; p.M107fs*3; 2:175118251-175118251	stomach	adenocarcinoma	Deletion - Frameshift
c.1000C>G; p.P334A; 2:175093246-175093246	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.730G>A; p.A244T; 2:175114005-175114005	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.688G>T; p.A230S; 2:175114047-175114047	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.373G>A; p.E125K; 2:175118064-175118064	pancreas	carcinoma	Substitution - Missense
c.474G>C; p.Q158H; 2:175114842-175114842	breast	carcinoma	Substitution - Missense
c.1331C>A; p.P444Q; 2:175074796-175074796	pancreas	carcinoma	Substitution - Missense
c.71_72CC>TT; p.P24L; 2:175130168-175130169	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.380C>T; p.S127F; 2:175118057-175118057	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1309A>G; p.S437G; 2:175074818-175074818	pancreas	carcinoma	Substitution - Missense
c.228G>A; p.L76L; 2:175118341-175118341	liver	carcinoma	Substitution - coding silent
c.228G>A; p.L76L; 2:175118341-175118341	liver	carcinoma	Substitution - coding silent
c.228G>A; p.L76L; 2:175118341-175118341	liver	carcinoma	Substitution - coding silent
c.862C>T; p.P288S; 2:175097560-175097560	skin	malignant_melanoma	Substitution - Missense
c.201T>G; p.D67E; 2:175118368-175118368	pancreas	carcinoma	Substitution - Missense
c.1119delG; p.V375fs*6; 2:175093127-175093127	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.799C>T; p.P267S; 2:175111597-175111597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.667A>G; p.N223D; 2:175114068-175114068	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.314A>C; p.K105T; 2:175118255-175118255	pancreas	NS	Substitution - Missense
c.314A>C; p.K105T; 2:175118255-175118255	pancreas	carcinoma	Substitution - Missense
c.1306G>A; p.D436N; 2:175074821-175074821	breast	carcinoma	Substitution - Missense
c.779G>A; p.G260E; 2:175111617-175111617	skin	malignant_melanoma	Substitution - Missense
c.1054G>C; p.D352H; 2:175093192-175093192	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.472C>T; p.Q158*; 2:175114844-175114844	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1117delA; p.R373fs*8; 2:175093129-175093129	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.26C>A; p.S9Y; 2:175136418-175136418	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.772G>T; p.V258F; 2:175111624-175111624	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.33-2A>C; p.?; 2:175130209-175130209	liver	carcinoma	Unknown
c.33-2A>C; p.?; 2:175130209-175130209	liver	carcinoma	Unknown
c.23A>T; p.N8I; 2:175136421-175136421	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.656T>C; p.L219S; 2:175114079-175114079	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.241G>T; p.E81*; 2:175118328-175118328	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1477G>A; p.V493I; 2:175074650-175074650	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.32+1G>T; p.?; 2:175136411-175136411	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.888A>G; p.K296K; 2:175097534-175097534	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.114C>T; p.N38N; 2:175121529-175121529	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.591A>G; p.V197V; 2:175114725-175114725	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1248A>G; p.K416K; 2:175080703-175080703	skin	malignant_melanoma	Substitution - coding silent
c.1015A>G; p.T339A; 2:175093231-175093231	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.794C>T; p.S265F; 2:175111602-175111602	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.431C>T; p.T144I; 2:175118006-175118006	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.121C>T; p.H41Y; 2:175121522-175121522	skin	malignant_melanoma	Substitution - Missense
c.1442C>T; p.A481V; 2:175074685-175074685	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1241C>T; p.A414V; 2:175080710-175080710	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1517G>T; p.*506L; 2:175074610-175074610	lung	carcinoma; adenocarcinoma	Nonstop extension
c.76C>G; p.L26V; 2:175130164-175130164	breast	carcinoma	Substitution - Missense
c.548T>C; p.V183A; 2:175114768-175114768	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.548T>C; p.V183A; 2:175114768-175114768	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.266C>T; p.A89V; 2:175118303-175118303	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.933A>G; p.R311R; 2:175097489-175097489	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1263C>T; p.T421T; 2:175080688-175080688	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.617G>T; p.R206M; 2:175114699-175114699	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.705T>C; p.I235I; 2:175114030-175114030	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.931C>T; p.R311*; 2:175097491-175097491	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1398C>A; p.T466T; 2:175074729-175074729	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1432A>T; p.T478S; 2:175074695-175074695	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1332G>A; p.P444P; 2:175074795-175074795	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.321G>A; p.M107I; 2:175118116-175118116	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1054G>T; p.D352Y; 2:175093192-175093192	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.771T>G; p.S257R; 2:175111625-175111625	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1088G>A; p.R363K; 2:175093158-175093158	skin	malignant_melanoma	Substitution - Missense
c.929C>T; p.S310F; 2:175097493-175097493	skin	malignant_melanoma	Substitution - Missense
c.217A>G; p.T73A; 2:175118352-175118352	pancreas	carcinoma	Substitution - Missense
c.208C>T; p.P70S; 2:175118361-175118361	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.944T>A; p.L315*; 2:175097478-175097478	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1367C>T; p.S456L; 2:175074760-175074760	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1055A>G; p.D352G; 2:175093191-175093191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1055A>G; p.D352G; 2:175093191-175093191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1501C>A; p.Q501K; 2:175074626-175074626	breast	carcinoma	Substitution - Missense
c.877G>C; p.D293H; 2:175097545-175097545	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.317A>G; p.K106R; 2:175118252-175118252	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.621_626+1delAATTGTG; p.?; 2:175114689-175114695	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.1313C>T; p.S438L; 2:175074814-175074814	skin	malignant_melanoma	Substitution - Missense
c.132C>T; p.V44V; 2:175121511-175121511	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1359G>T; p.Q453H; 2:175074768-175074768	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.816A>G; p.S272S; 2:175111580-175111580	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.806C>A; p.P269Q; 2:175111590-175111590	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.248G>A; p.G83D; 2:175118321-175118321	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.225C>A; p.F75L; 2:175118344-175118344	breast	carcinoma	Substitution - Missense
c.85G>T; p.A29S; 2:175130155-175130155	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1246A>G; p.K416E; 2:175080705-175080705	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1048G>T; p.D350Y; 2:175093198-175093198	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.272C>T; p.P91L; 2:175118297-175118297	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.442G>A; p.E148K; 2:175117995-175117995	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.922G>C; p.E308Q; 2:175097500-175097500	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.935C>T; p.P312L; 2:175097487-175097487	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.935C>T; p.P312L; 2:175097487-175097487	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation