lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1361
Symbol	CPB2
Synonymous	CPU\|PCPB\|TAFI
Full name	carboxypeptidase B2 (plasma)
Gene description	carboxypeptidase B-like protein\|carboxypeptidase B2\|carboxypeptidase B2 (plasma, carboxypeptidase U)\|carboxypeptidase R\|thrombin-activable fibrinolysis inhibitor\|thrombin-activatable fibrinolysis inhibitor
Cytoband	13q14.11
Gene type	protein-coding
Synonymous	MIM:603101; HGNC:HGNC:2300; Ensembl:ENSG00000080618; HPRD:04374; Vega:OTTHUMG00000016867

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.826G>A; p.E276K; 13:46058352-46058352	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.167C>T; p.P56L; 13:46084327-46084327	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.505G>A; p.A169T; 13:46073959-46073959	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1240A>C; p.K414Q; 13:46053646-46053646	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1096C>G; p.P366A; 13:46053790-46053790	breast	carcinoma	Substitution - Missense
c.5A>C; p.K2T; 13:46105005-46105005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.262G>T; p.G88*; 13:46084232-46084232	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.553T>A; p.W185R; 13:46073911-46073911	pancreas	carcinoma	Substitution - Missense
c.1231G>A; p.A411T; 13:46053655-46053655	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.745C>A; p.H249N; 13:46064699-46064699	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.231C>T; p.V77V; 13:46084263-46084263	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.65C>T; p.A22V; 13:46104945-46104945	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.65C>T; p.A22V; 13:46104945-46104945	pancreas	carcinoma	Substitution - Missense
c.213delT; p.F71fs*2; 13:46084281-46084281	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.354G>A; p.S118S; 13:46082471-46082471	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.478G>T; p.V160F; 13:46078808-46078808	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.478G>T; p.V160F; 13:46078808-46078808	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.478G>T; p.V160F; 13:46078808-46078808	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.384+1G>A; p.?; 13:46082440-46082440	lung	carcinoma; adenocarcinoma	Unknown
c.478G>T; p.V160F; 13:46078808-46078808	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.478G>T; p.V160F; 13:46078808-46078808	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.994G>A; p.E332K; 13:46058184-46058184	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1196G>A; p.R399H; 13:46053690-46053690	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.145T>C; p.Y49H; 13:46087750-46087750	urinary_tract; bladder	carcinoma	Substitution - Missense
c.75-1G>A; p.?; 13:46087821-46087821	stomach	carcinoma; adenocarcinoma	Unknown
c.261C>T; p.S87S; 13:46084233-46084233	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.707G>A; p.R236Q; 13:46064737-46064737	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.707G>A; p.R236Q; 13:46064737-46064737	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.707G>A; p.R236Q; 13:46064737-46064737	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.213_214insT; p.V72fs*5; 13:46084280-46084281	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.663A>G; p.P221P; 13:46067346-46067346	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.168G>A; p.P56P; 13:46084326-46084326	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.760G>T; p.D254Y; 13:46064684-46064684	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1067G>A; p.G356D; 13:46055782-46055782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1067G>A; p.G356D; 13:46055782-46055782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1226T>C; p.F409S; 13:46053660-46053660	skin	malignant_melanoma	Substitution - Missense
c.888G>T; p.L296F; 13:46058290-46058290	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.340C>T; p.R114*; 13:46082485-46082485	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Nonsense
c.779C>A; p.A260D; 13:46064665-46064665	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.192G>C; p.K64N; 13:46084302-46084302	breast	carcinoma	Substitution - Missense
c.1176C>T; p.Y392Y; 13:46053710-46053710	prostate	carcinoma	Substitution - coding silent
c.753C>A; p.I251I; 13:46064691-46064691	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.159C>G; p.L53L; 13:46084335-46084335	liver	carcinoma	Substitution - coding silent
c.159C>G; p.L53L; 13:46084335-46084335	liver	carcinoma	Substitution - coding silent
c.33C>A; p.P11P; 13:46104977-46104977	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.198delA; p.K66fs*7; 13:46084296-46084296	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.150+2T>C; p.?; 13:46087743-46087743	stomach	carcinoma; adenocarcinoma	Unknown
c.1015G>T; p.E339*; 13:46055834-46055834	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.548G>C; p.R183T; 13:46073916-46073916	NS	NS	Substitution - Missense
c.971G>A; p.R324Q; 13:46058207-46058207	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.797-7G>A; p.?; 13:46058388-46058388	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.7C>T; p.L3F; 13:46105003-46105003	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.701delA; p.K234fs*22; 13:46067308-46067308	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.340delC; p.R114fs*13; 13:46082485-46082485	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.947T>C; p.I316T; 13:46058231-46058231	urinary_tract; bladder	carcinoma	Substitution - Missense
c.947T>C; p.I316T; 13:46058231-46058231	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.412G>A; p.E138K; 13:46078874-46078874	skin	malignant_melanoma	Substitution - Missense
c.150G>A; p.E50E; 13:46087745-46087745	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1103G>T; p.G368V; 13:46053783-46053783	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.678T>C; p.D226D; 13:46067331-46067331	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.706C>T; p.R236*; 13:46064738-46064738	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.608G>A; p.G203E; 13:46067401-46067401	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.755G>A; p.G252E; 13:46064689-46064689	skin	malignant_melanoma	Substitution - Missense
c.586G>T; p.G196C; 13:46073878-46073878	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.755G>A; p.G252E; 13:46064689-46064689	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.434C>T; p.T145I; 13:46078852-46078852	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.382G>A; p.E128K; 13:46082443-46082443	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.442C>A; p.H148N; 13:46078844-46078844	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1073G>C; p.G358A; 13:46055776-46055776	pancreas	carcinoma	Substitution - Missense
c.698A>G; p.K233R; 13:46067311-46067311	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1215T>C; p.C405C; 13:46053671-46053671	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.845A>G; p.Y282C; 13:46058333-46058333	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.232G>A; p.D78N; 13:46084262-46084262	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.826G>T; p.E276*; 13:46058352-46058352	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Nonsense
c.210T>G; p.F70L; 13:46084284-46084284	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1125T>G; p.D375E; 13:46053761-46053761	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.263G>A; p.G88E; 13:46084231-46084231	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.762C>T; p.D254D; 13:46064682-46064682	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.616G>A; p.G206R; 13:46067393-46067393	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.854C>T; p.S285L; 13:46058324-46058324	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.508G>T; p.A170S; 13:46073956-46073956	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.16C>T; p.L6F; 13:46104994-46104994	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.491C>T; p.S164F; 13:46073973-46073973	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1210A>C; p.T404P; 13:46053676-46053676	breast	carcinoma	Substitution - Missense
c.713G>A; p.W238*; 13:46064731-46064731	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.859C>A; p.P287T; 13:46058319-46058319	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1241A>G; p.K414R; 13:46053645-46053645	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1060A>G; p.T354A; 13:46055789-46055789	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.975T>A; p.S325R; 13:46058203-46058203	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.603C>A; p.F201L; 13:46067406-46067406	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1244T>C; p.I415T; 13:46053642-46053642	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.790T>C; p.W264R; 13:46064654-46064654	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.275G>A; p.S92N; 13:46084219-46084219	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1142C>T; p.S381L; 13:46053744-46053744	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.966T>A; p.Y322*; 13:46058212-46058212	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.966T>A; p.Y322*; 13:46058212-46058212	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.712T>C; p.W238R; 13:46064732-46064732	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.178G>A; p.D60N; 13:46084316-46084316	urinary_tract; bladder	carcinoma	Substitution - Missense
c.364C>T; p.Q122*; 13:46082461-46082461	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1070A>G; p.H357R; 13:46055779-46055779	liver	carcinoma	Substitution - Missense
c.150+8C>T; p.?; 13:46087737-46087737	pancreas	carcinoma	Unknown
c.833A>G; p.Y278C; 13:46058345-46058345	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1206A>C; p.K402N; 13:46053680-46053680	breast	carcinoma	Substitution - Missense
c.714G>A; p.W238*; 13:46064730-46064730	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.341G>T; p.R114L; 13:46082484-46082484	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.400G>T; p.E134*; 13:46078886-46078886	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.400G>T; p.E134*; 13:46078886-46078886	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.400G>T; p.E134*; 13:46078886-46078886	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.64G>A; p.A22T; 13:46104946-46104946	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.797-1G>A; p.?; 13:46058382-46058382	stomach	carcinoma; adenocarcinoma	Unknown
c.24C>T; p.V8V; 13:46104986-46104986	liver	carcinoma	Substitution - coding silent
c.24C>T; p.V8V; 13:46104986-46104986	liver	carcinoma	Substitution - coding silent
c.24C>T; p.V8V; 13:46104986-46104986	liver	carcinoma	Substitution - coding silent
c.664G>A; p.V222M; 13:46067345-46067345	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.753C>T; p.I251I; 13:46064691-46064691	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.753C>T; p.I251I; 13:46064691-46064691	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.307C>T; p.Q103*; 13:46082518-46082518	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1053C>A; p.T351T; 13:46055796-46055796	breast	carcinoma	Substitution - coding silent
c.292G>A; p.V98M; 13:46082533-46082533	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.97C>T; p.P33S; 13:46087798-46087798	skin	malignant_melanoma	Substitution - Missense
c.940C>G; p.Q314E; 13:46058238-46058238	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation