lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	128209
Symbol	KLF17
Synonymous	ZNF393\|Zfp393
Full name	Kruppel-like factor 17
Gene description	Krueppel-like factor 17\|novel zinc-finger protein\|zinc finger protein 393
Cytoband	1p34.1
Gene type	protein-coding
Synonymous	MIM:609602; HGNC:HGNC:18830; Ensembl:ENSG00000171872; HPRD:08272; Vega:OTTHUMG00000009664

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.374C>T; p.T125M; 1:44129645-44129645	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.264G>A; p.Q88Q; 1:44129535-44129535	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.968C>A; p.S323Y; 1:44130554-44130554	pancreas	carcinoma	Substitution - Missense
c.395T>C; p.L132P; 1:44129666-44129666	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.813G>A; p.G271G; 1:44130084-44130084	skin	malignant_melanoma	Substitution - coding silent
c.529G>A; p.V177M; 1:44129800-44129800	skin	malignant_melanoma	Substitution - Missense
c.14C>T; p.P5L; 1:44118921-44118921	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.483G>A; p.S161S; 1:44129754-44129754	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.483G>A; p.S161S; 1:44129754-44129754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1156G>C; p.A386P; 1:44130742-44130742	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.170G>C; p.S57T; 1:44129441-44129441	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1086G>A; p.Q362Q; 1:44130672-44130672	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.211C>A; p.P71T; 1:44129482-44129482	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.925+1G>A; p.?; 1:44130197-44130197	skin	malignant_melanoma	Unknown
c.447G>A; p.G149G; 1:44129718-44129718	skin	malignant_melanoma	Substitution - coding silent
c.99G>A; p.A33A; 1:44129370-44129370	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.250G>A; p.E84K; 1:44129521-44129521	skin	malignant_melanoma	Substitution - Missense
c.438C>G; p.P146P; 1:44129709-44129709	breast	carcinoma	Substitution - coding silent
c.725A>G; p.Q242R; 1:44129996-44129996	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.725A>G; p.Q242R; 1:44129996-44129996	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.734C>A; p.S245Y; 1:44130005-44130005	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.42G>A; p.G14G; 1:44118949-44118949	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.11G>A; p.R4Q; 1:44118918-44118918	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.407G>A; p.G136E; 1:44129678-44129678	skin	malignant_melanoma	Substitution - Missense
c.739G>A; p.E247K; 1:44130010-44130010	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1084C>T; p.Q362*; 1:44130670-44130670	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.726G>T; p.Q242H; 1:44129997-44129997	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1022G>A; p.R341Q; 1:44130608-44130608	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.294G>A; p.M98I; 1:44129565-44129565	skin	malignant_melanoma	Substitution - Missense
c.1048C>T; p.R350W; 1:44130634-44130634	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.83A>G; p.D28G; 1:44129354-44129354	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1072C>T; p.L358F; 1:44130658-44130658	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.88G>A; p.E30K; 1:44129359-44129359	skin	malignant_melanoma	Substitution - Missense
c.312G>A; p.A104A; 1:44129583-44129583	skin	malignant_melanoma	Substitution - coding silent
c.620C>T; p.S207F; 1:44129891-44129891	skin	malignant_melanoma	Substitution - Missense
c.88G>A; p.E30K; 1:44129359-44129359	skin	malignant_melanoma	Substitution - Missense
c.649G>A; p.A217T; 1:44129920-44129920	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.519G>T; p.G173G; 1:44129790-44129790	liver	carcinoma	Substitution - coding silent
c.519G>T; p.G173G; 1:44129790-44129790	liver	carcinoma	Substitution - coding silent
c.975C>T; p.F325F; 1:44130561-44130561	skin	malignant_melanoma	Substitution - coding silent
c.564C>T; p.D188D; 1:44129835-44129835	thyroid	other; neoplasm	Substitution - coding silent
c.356C>T; p.P119L; 1:44129627-44129627	skin	malignant_melanoma	Substitution - Missense
c.1001T>A; p.M334K; 1:44130587-44130587	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.532C>T; p.P178S; 1:44129803-44129803	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.724C>T; p.Q242*; 1:44129995-44129995	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1160C>T; p.A387V; 1:44130746-44130746	skin	malignant_melanoma	Substitution - Missense
c.231G>A; p.A77A; 1:44129502-44129502	pancreas	carcinoma	Substitution - coding silent
c.445G>A; p.G149R; 1:44129716-44129716	breast	carcinoma	Substitution - Missense
c.914G>A; p.R305H; 1:44130185-44130185	skin	malignant_melanoma	Substitution - Missense
c.351G>C; p.M117I; 1:44129622-44129622	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.195A>C; p.A65A; 1:44129466-44129466	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.329G>A; p.R110Q; 1:44129600-44129600	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.329G>A; p.R110Q; 1:44129600-44129600	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.837G>T; p.E279D; 1:44130108-44130108	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.837G>A; p.E279E; 1:44130108-44130108	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.442G>T; p.G148C; 1:44129713-44129713	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.305C>A; p.P102H; 1:44129576-44129576	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1101G>A; p.P367P; 1:44130687-44130687	thyroid	other; neoplasm	Substitution - coding silent
c.517G>A; p.G173R; 1:44129788-44129788	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.294G>T; p.M98I; 1:44129565-44129565	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.499C>T; p.P167S; 1:44129770-44129770	skin	malignant_melanoma	Substitution - Missense
c.416A>T; p.N139I; 1:44129687-44129687	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.65C>T; p.A22V; 1:44118972-44118972	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.616C>T; p.P206S; 1:44129887-44129887	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.724C>A; p.Q242K; 1:44129995-44129995	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.82-1G>A; p.?; 1:44129352-44129352	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.1114C>A; p.P372T; 1:44130700-44130700	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.442G>A; p.G148S; 1:44129713-44129713	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1125C>A; p.N375K; 1:44130711-44130711	ovary	other; neoplasm	Substitution - Missense
c.63G>A; p.A21A; 1:44118970-44118970	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.406G>A; p.G136R; 1:44129677-44129677	skin	malignant_melanoma	Substitution - Missense
c.7G>A; p.G3S; 1:44118914-44118914	liver	carcinoma	Substitution - Missense
c.7G>A; p.G3S; 1:44118914-44118914	liver	carcinoma	Substitution - Missense
c.360T>A; p.P120P; 1:44129631-44129631	breast	carcinoma; ductal_carcinoma	Substitution - coding silent
c.149C>G; p.S50C; 1:44129420-44129420	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1083C>T; p.H361H; 1:44130669-44130669	liver	carcinoma	Substitution - coding silent
c.1083C>T; p.H361H; 1:44130669-44130669	liver	carcinoma	Substitution - coding silent
c.1003C>A; p.R335R; 1:44130589-44130589	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.864G>T; p.E288D; 1:44130135-44130135	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.414C>T; p.P138P; 1:44129685-44129685	skin	malignant_melanoma	Substitution - coding silent
c.43G>A; p.E15K; 1:44118950-44118950	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.193G>A; p.A65T; 1:44129464-44129464	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.193G>A; p.A65T; 1:44129464-44129464	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.467A>G; p.N156S; 1:44129738-44129738	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.467A>G; p.N156S; 1:44129738-44129738	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.930G>T; p.E310D; 1:44130516-44130516	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.357_358CC>TT; p.P120S; 1:44129628-44129629	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.482C>T; p.S161L; 1:44129753-44129753	skin	malignant_melanoma	Substitution - Missense
c.66G>C; p.A22A; 1:44118973-44118973	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.872G>A; p.G291E; 1:44130143-44130143	skin	malignant_melanoma	Substitution - Missense
c.872G>A; p.G291E; 1:44130143-44130143	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.870C>T; p.C290C; 1:44130141-44130141	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.842G>T; p.R281M; 1:44130113-44130113	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.751C>T; p.L251L; 1:44130022-44130022	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.885C>A; p.T295T; 1:44130156-44130156	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.10C>T; p.R4*; 1:44118917-44118917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.581C>G; p.P194R; 1:44129852-44129852	skin	malignant_melanoma	Substitution - Missense
c.1039_1043delCAGTG; p.C348fs*7; 1:44130625-44130629	breast	carcinoma	Deletion - Frameshift
c.297C>T; p.S99S; 1:44129568-44129568	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.302G>T; p.C101F; 1:44129573-44129573	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.302G>T; p.C101F; 1:44129573-44129573	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; T_cell_large_granular_lymphocytic_leukaemia	Substitution - Missense
c.581C>T; p.P194L; 1:44129852-44129852	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.421C>T; p.P141S; 1:44129692-44129692	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274C>T; p.P92S; 1:44129545-44129545	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.234G>T; p.P78P; 1:44129505-44129505	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.504A>G; p.I168M; 1:44129775-44129775	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.233C>T; p.P78L; 1:44129504-44129504	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.102C>A; p.P34P; 1:44129373-44129373	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.976C>T; p.R326C; 1:44130562-44130562	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1056C>T; p.F352F; 1:44130642-44130642	skin	malignant_melanoma	Substitution - coding silent
c.287G>A; p.R96H; 1:44129558-44129558	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.244G>A; p.V82M; 1:44129515-44129515	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.287G>A; p.R96H; 1:44129558-44129558	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.542G>A; p.G181D; 1:44129813-44129813	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.542G>A; p.G181D; 1:44129813-44129813	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1049G>A; p.R350Q; 1:44130635-44130635	prostate	carcinoma	Substitution - Missense
c.289G>T; p.G97C; 1:44129560-44129560	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.962C>T; p.S321L; 1:44130548-44130548	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.119C>A; p.S40*; 1:44129390-44129390	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.500C>T; p.P167L; 1:44129771-44129771	NS	malignant_melanoma	Substitution - Missense
c.104T>A; p.I35N; 1:44129375-44129375	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.544C>T; p.L182F; 1:44129815-44129815	skin; shoulder	malignant_melanoma	Substitution - Missense
c.104T>A; p.I35N; 1:44129375-44129375	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.104T>A; p.I35N; 1:44129375-44129375	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.104T>A; p.I35N; 1:44129375-44129375	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation