lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	116844
Symbol	LRG1
Synonymous	HMFT1766\|LRG
Full name	leucine-rich alpha-2-glycoprotein 1
Gene description	1300008B03Rik\|2310031E04Rik\|leucine rich alpha 2 glycoprotein\|leucine-rich alpha-2-glycoprotein
Cytoband	19p13.3
Gene type	protein-coding
Synonymous	MIM:611289; HGNC:HGNC:29480; HPRD:10056

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.76C>A; p.L26M; 19:4538908-4538908	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.338G>A; p.R113Q; 19:4538646-4538646	breast	carcinoma	Substitution - Missense
c.945G>A; p.Q315Q; 19:4538039-4538039	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.150T>C; p.H50H; 19:4538834-4538834	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.524G>A; p.R175H; 19:4538460-4538460	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.561C>T; p.F187F; 19:4538423-4538423	skin	malignant_melanoma	Substitution - coding silent
c.271G>A; p.A91T; 19:4538713-4538713	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.475T>G; p.W159G; 19:4538509-4538509	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.519G>A; p.G173G; 19:4538465-4538465	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.982C>T; p.R328C; 19:4538002-4538002	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.8C>T; p.S3F; 19:4540006-4540006	skin	malignant_melanoma	Substitution - Missense
c.374G>A; p.R125Q; 19:4538610-4538610	NS	malignant_melanoma	Substitution - Missense
c.761G>A; p.G254D; 19:4538223-4538223	skin	malignant_melanoma	Substitution - Missense
c.543_544insC; p.G182fs*13; 19:4538440-4538441	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.872G>A; p.R291Q; 19:4538112-4538112	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.84G>T; p.L28L; 19:4538900-4538900	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.882C>T; p.F294F; 19:4538102-4538102	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.708G>A; p.P236P; 19:4538276-4538276	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.708G>A; p.P236P; 19:4538276-4538276	breast	carcinoma	Substitution - coding silent
c.708G>A; p.P236P; 19:4538276-4538276	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.613C>T; p.P205S; 19:4538371-4538371	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.704_705insA; p.P236fs*35; 19:4538279-4538280	breast	carcinoma	Insertion - Frameshift
c.934C>T; p.R312C; 19:4538050-4538050	skin	malignant_melanoma	Substitution - Missense
c.934C>T; p.R312C; 19:4538050-4538050	skin	malignant_melanoma	Substitution - Missense
c.192C>T; p.G64G; 19:4538792-4538792	skin	malignant_melanoma	Substitution - coding silent
c.397C>T; p.P133S; 19:4538587-4538587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.397C>T; p.P133S; 19:4538587-4538587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.397C>T; p.P133S; 19:4538587-4538587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.186C>T; p.I62I; 19:4538798-4538798	skin	malignant_melanoma	Substitution - coding silent
c.58T>C; p.S20P; 19:4538926-4538926	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.379G>A; p.A127T; 19:4538605-4538605	oesophagus	carcinoma	Substitution - Missense
c.871C>T; p.R291W; 19:4538113-4538113	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.62G>A; p.R21K; 19:4538922-4538922	skin	malignant_melanoma	Substitution - Missense
c.328G>A; p.E110K; 19:4538656-4538656	skin	malignant_melanoma	Substitution - Missense
c.515C>A; p.S172Y; 19:4538469-4538469	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.333C>T; p.F111F; 19:4538651-4538651	skin	malignant_melanoma	Substitution - coding silent
c.333C>T; p.F111F; 19:4538651-4538651	skin	malignant_melanoma	Substitution - coding silent
c.346C>T; p.P116S; 19:4538638-4538638	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.727C>T; p.L243L; 19:4538257-4538257	skin	malignant_melanoma	Substitution - coding silent
c.323C>T; p.S108L; 19:4538661-4538661	skin	malignant_melanoma	Substitution - Missense
c.323C>T; p.S108L; 19:4538661-4538661	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.165C>T; p.S55S; 19:4538819-4538819	skin	malignant_melanoma	Substitution - coding silent
c.1037C>T; p.S346F; 19:4537947-4537947	skin	malignant_melanoma	Substitution - Missense
c.169C>T; p.Q57*; 19:4538815-4538815	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.626G>T; p.R209M; 19:4538358-4538358	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.382C>A; p.L128M; 19:4538602-4538602	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.683G>A; p.G228E; 19:4538301-4538301	skin	malignant_melanoma	Substitution - Missense
c.823G>A; p.V275M; 19:4538161-4538161	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.823G>A; p.V275M; 19:4538161-4538161	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.823G>A; p.V275M; 19:4538161-4538161	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1001C>T; p.A334V; 19:4537983-4537983	skin	malignant_melanoma	Substitution - Missense
c.691C>A; p.L231I; 19:4538293-4538293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.678A>G; p.V226V; 19:4538306-4538306	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.582C>T; p.D194D; 19:4538402-4538402	skin	malignant_melanoma	Substitution - coding silent
c.943C>T; p.Q315*; 19:4538041-4538041	skin	malignant_melanoma	Substitution - Nonsense
c.44T>C; p.I15T; 19:4538940-4538940	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.522C>A; p.N174K; 19:4538462-4538462	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.898C>T; p.P300S; 19:4538086-4538086	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.748A>T; p.R250W; 19:4538236-4538236	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.286G>A; p.E96K; 19:4538698-4538698	breast	carcinoma	Substitution - Missense
c.181G>A; p.E61K; 19:4538803-4538803	urinary_tract; bladder	carcinoma	Substitution - Missense
c.539C>A; p.P180H; 19:4538445-4538445	urinary_tract; bladder	carcinoma	Substitution - Missense
c.541C>T; p.P181S; 19:4538443-4538443	skin	malignant_melanoma	Substitution - Missense
c.327C>T; p.P109P; 19:4538657-4538657	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.398C>T; p.P133L; 19:4538586-4538586	skin	malignant_melanoma	Substitution - Missense
c.768C>T; p.F256F; 19:4538216-4538216	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation