lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	116
Symbol	ADCYAP1
Synonymous	PACAP
Full name	adenylate cyclase activating polypeptide 1 (pituitary)
Gene description	pituitary adenylate cyclase-activating polypeptide\|prepro-PACAP
Cytoband	18p11
Gene type	protein-coding
Synonymous	MIM:102980; HGNC:HGNC:241; Ensembl:ENSG00000141433; HPRD:02369; Vega:OTTHUMG00000131479

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.75A>C; p.S25S; 18:905461-905461	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.85G>A; p.A29T; 18:905471-905471	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.379C>G; p.P127A; 18:909483-909483	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.257G>T; p.G86V; 18:908279-908279	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.257G>T; p.G86V; 18:908279-908279	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.15C>A; p.S5R; 18:905401-905401	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.376G>A; p.E126K; 18:909480-909480	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.374C>T; p.A125V; 18:909478-909478	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.515G>A; p.R172Q; 18:909619-909619	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.515G>A; p.R172Q; 18:909619-909619	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.515G>A; p.R172Q; 18:909619-909619	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.515G>A; p.R172Q; 18:909619-909619	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.136G>C; p.D46H; 18:907684-907684	urinary_tract; bladder	carcinoma	Substitution - Missense
c.268G>A; p.E90K; 18:908290-908290	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.490C>A; p.Q164K; 18:909594-909594	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.5C>T; p.T2I; 18:905391-905391	skin	malignant_melanoma	Substitution - Missense
c.133G>A; p.E45K; 18:907681-907681	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.250G>A; p.A84T; 18:908272-908272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.250G>A; p.A84T; 18:908272-908272	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.110+4G>T; p.?; 18:905500-905500	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.97T>C; p.F33L; 18:905483-905483	skin	malignant_melanoma	Substitution - Missense
c.54G>A; p.M18I; 18:905440-905440	pancreas	carcinoma	Substitution - Missense
c.54G>A; p.M18I; 18:905440-905440	pancreas	carcinoma	Substitution - Missense
c.3G>T; p.M1I; 18:905389-905389	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.306G>A; p.G102G; 18:908328-908328	skin	malignant_melanoma	Substitution - coding silent
c.82G>T; p.A28S; 18:905468-905468	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.159C>T; p.F53F; 18:907707-907707	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.300C>T; p.S100S; 18:908322-908322	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.99C>T; p.F33F; 18:905485-905485	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.434G>A; p.R145Q; 18:909538-909538	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.434G>A; p.R145Q; 18:909538-909538	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.88G>A; p.G30R; 18:905474-905474	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.16G>A; p.G6R; 18:905402-905402	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.16G>A; p.G6R; 18:905402-905402	skin	malignant_melanoma	Substitution - Missense
c.100C>T; p.P34S; 18:905486-905486	skin	malignant_melanoma	Substitution - Missense
c.56A>G; p.H19R; 18:905442-905442	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.31C>A; p.L11M; 18:905417-905417	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.126G>A; p.A42A; 18:907674-907674	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.126G>A; p.A42A; 18:907674-907674	thyroid	other; neoplasm	Substitution - coding silent
c.126G>A; p.A42A; 18:907674-907674	thyroid	other; neoplasm	Substitution - coding silent
c.126G>A; p.A42A; 18:907674-907674	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.126G>A; p.A42A; 18:907674-907674	thyroid	other; neoplasm	Substitution - coding silent
c.126G>A; p.A42A; 18:907674-907674	breast	carcinoma	Substitution - coding silent
c.126G>A; p.A42A; 18:907674-907674	thyroid	other; neoplasm	Substitution - coding silent
c.456A>G; p.K152K; 18:909560-909560	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.456A>G; p.K152K; 18:909560-909560	breast	carcinoma	Substitution - coding silent
c.105G>A; p.G35G; 18:905491-905491	skin	malignant_melanoma	Substitution - coding silent
c.311A>G; p.H104R; 18:908333-908333	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.428G>A; p.R143H; 18:909532-909532	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.367G>T; p.D123Y; 18:909471-909471	liver	carcinoma	Substitution - Missense
c.367G>T; p.D123Y; 18:909471-909471	liver	carcinoma	Substitution - Missense
c.295C>A; p.L99M; 18:908317-908317	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.77C>A; p.P26H; 18:905463-905463	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.477G>A; p.G159G; 18:909581-909581	skin	malignant_melanoma	Substitution - coding silent
c.272C>T; p.A91V; 18:908294-908294	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.39C>T; p.V13V; 18:905425-905425	skin	malignant_melanoma	Substitution - coding silent
c.161A>G; p.D54G; 18:907709-907709	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.161A>G; p.D54G; 18:907709-907709	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.488A>C; p.K163T; 18:909592-909592	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.39C>A; p.V13V; 18:905425-905425	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.400G>C; p.D134H; 18:909504-909504	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.515G>T; p.R172L; 18:909619-909619	lung	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation