lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	11202
Symbol	KLK8
Synonymous	HNP\|NP\|NRPN\|PRSS19\|TADG14
Full name	kallikrein-related peptidase 8
Gene description	kallikrein-8\|ovasin\|serine protease 19\|serine protease TADG-14\|tumor-associated differentially expressed gene 14 protein
Cytoband	19q13
Gene type	protein-coding
Synonymous	MIM:605644; HGNC:HGNC:6369; Ensembl:ENSG00000129455; HPRD:05733; Vega:OTTHUMG00000183086

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.400C>G; p.Q134E; 19:51000224-51000224	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.366-10A>G; p.?; 19:51000268-51000268	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.874C>T; p.R292C; 19:50996103-50996103	breast	carcinoma	Substitution - Missense
c.777C>A; p.G259G; 19:50996200-50996200	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.777C>A; p.G259G; 19:50996200-50996200	pancreas	carcinoma	Substitution - coding silent
c.913G>C; p.G305R; 19:50996064-50996064	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.635T>A; p.F212Y; 19:50997878-50997878	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.858C>G; p.V286V; 19:50996119-50996119	skin	malignant_melanoma	Substitution - coding silent
c.366G>A; p.P122P; 19:51000258-51000258	skin	malignant_melanoma	Substitution - coding silent
c.769T>G; p.S257A; 19:50996208-50996208	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.350C>T; p.A117V; 19:51000439-51000439	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.718G>T; p.G240C; 19:50997795-50997795	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.379C>T; p.R127C; 19:51000245-51000245	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.379C>T; p.R127C; 19:51000245-51000245	prostate	carcinoma	Substitution - Missense
c.669C>A; p.I223I; 19:50997844-50997844	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.778C>A; p.P260T; 19:50996199-50996199	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.763-2A>T; p.?; 19:50996216-50996216	lung	carcinoma; small_cell_carcinoma	Unknown
c.873C>T; p.C291C; 19:50996104-50996104	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.424G>T; p.E142*; 19:51000200-51000200	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.856G>A; p.V286I; 19:50996121-50996121	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.856G>A; p.V286I; 19:50996121-50996121	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.856G>A; p.V286I; 19:50996121-50996121	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.856G>A; p.V286I; 19:50996121-50996121	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.856G>A; p.V286I; 19:50996121-50996121	liver	carcinoma	Substitution - Missense
c.856G>A; p.V286I; 19:50996121-50996121	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.856G>A; p.V286I; 19:50996121-50996121	central_nervous_system; brain	glioma	Substitution - Missense
c.844G>A; p.D282N; 19:50996133-50996133	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.622C>T; p.P208S; 19:51000002-51000002	skin	malignant_melanoma	Substitution - Missense
c.313G>A; p.G105S; 19:51000476-51000476	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.847A>T; p.K283*; 19:50996130-50996130	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.378A>G; p.V126V; 19:51000246-51000246	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.378A>G; p.V126V; 19:51000246-51000246	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.891C>G; p.I297M; 19:50996086-50996086	skin	malignant_melanoma	Substitution - Missense
c.620G>T; p.S207I; 19:51000004-51000004	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.188C>T; p.P63L; 19:51000601-51000601	skin	malignant_melanoma	Substitution - Missense
c.260A>G; p.H87R; 19:51000529-51000529	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.454C>T; p.P152S; 19:51000170-51000170	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.454C>T; p.P152S; 19:51000170-51000170	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.447C>T; p.I149I; 19:51000177-51000177	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.447C>T; p.I149I; 19:51000177-51000177	pancreas	carcinoma	Substitution - coding silent
c.491A>G; p.H164R; 19:51000133-51000133	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.234G>A; p.V78V; 19:51000555-51000555	pancreas	carcinoma	Substitution - coding silent
c.626G>A; p.R209Q; 19:50999998-50999998	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.821G>T; p.G274V; 19:50996156-50996156	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.318C>T; p.V106V; 19:51000471-51000471	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.107C>T; p.A36V; 19:51000682-51000682	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.554G>A; p.S185N; 19:51000070-51000070	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.853G>T; p.G285C; 19:50996124-50996124	oesophagus	carcinoma	Substitution - Missense
c.469A>T; p.S157C; 19:51000155-51000155	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.843C>T; p.S281S; 19:50996134-50996134	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.843C>T; p.S281S; 19:50996134-50996134	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.681G>A; p.K227K; 19:50997832-50997832	skin	malignant_melanoma	Substitution - coding silent
c.223G>A; p.E75K; 19:51000566-51000566	skin	malignant_melanoma	Substitution - Missense
c.917G>A; p.306; 19:50996060-50996060	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.223G>A; p.E75K; 19:51000566-51000566	skin	malignant_melanoma	Substitution - Missense
c.380G>A; p.R127H; 19:51000244-51000244	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.810C>T; p.I270I; 19:50996167-50996167	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.268C>A; p.P90T; 19:51000521-51000521	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.790G>A; p.D264N; 19:50996187-50996187	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.562G>A; p.D188N; 19:51000062-51000062	urinary_tract; bladder	carcinoma	Substitution - Missense
c.536C>A; p.S179Y; 19:51000088-51000088	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.877T>C; p.Y293H; 19:50996100-50996100	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.56G>A; p.G19E; 19:51001112-51001112	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.247G>A; p.E83K; 19:51000542-51000542	skin	malignant_melanoma	Substitution - Missense
c.158C>T; p.S53L; 19:51000631-51000631	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.851C>T; p.P284L; 19:50996126-50996126	skin	malignant_melanoma	Substitution - Missense
c.82C>A; p.L28M; 19:51000707-51000707	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.278C>T; p.A93V; 19:51000511-51000511	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.278C>T; p.A93V; 19:51000511-51000511	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.11C>T; p.P4L; 19:51001157-51001157	skin	malignant_melanoma	Substitution - Missense
c.821G>C; p.G274A; 19:50996156-50996156	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.472G>A; p.D158N; 19:51000152-51000152	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.475G>A; p.V159M; 19:51000149-51000149	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.844G>T; p.D282Y; 19:50996133-50996133	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.506T>G; p.L169R; 19:51000118-51000118	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.106G>A; p.A36T; 19:51000683-51000683	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.523G>A; p.A175T; 19:51000101-51000101	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.784G>T; p.V262L; 19:50996193-50996193	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.802C>T; p.Q268*; 19:50996175-50996175	skin	malignant_melanoma	Substitution - Nonsense
c.802C>T; p.Q268*; 19:50996175-50996175	skin	malignant_melanoma	Substitution - Nonsense
c.276G>A; p.Q92Q; 19:51000513-51000513	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.763-1G>T; p.?; 19:50996215-50996215	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.875G>A; p.R292H; 19:50996102-50996102	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.875G>A; p.R292H; 19:50996102-50996102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.875G>A; p.R292H; 19:50996102-50996102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.875G>A; p.R292H; 19:50996102-50996102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.505C>T; p.L169F; 19:51000119-51000119	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.257C>T; p.P86L; 19:51000532-51000532	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.257C>T; p.P86L; 19:51000532-51000532	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.257C>T; p.P86L; 19:51000532-51000532	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.177G>A; p.W59*; 19:51000612-51000612	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.711C>A; p.I237I; 19:50997802-50997802	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.451C>T; p.H151Y; 19:51000173-51000173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.451C>T; p.H151Y; 19:51000173-51000173	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.289C>T; p.Q97*; 19:51000500-51000500	skin	malignant_melanoma	Substitution - Nonsense
c.820G>A; p.G274S; 19:50996157-50996157	skin	malignant_melanoma	Substitution - Missense
c.703G>A; p.G235R; 19:50997810-50997810	skin	malignant_melanoma	Substitution - Missense
c.311G>T; p.G104V; 19:51000478-51000478	breast	carcinoma	Substitution - Missense
c.381C>A; p.R127R; 19:51000243-51000243	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.411T>C; p.D137D; 19:51000213-51000213	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.158C>G; p.S53W; 19:51000631-51000631	breast	carcinoma	Substitution - Missense
c.59delG; p.G20fs*25; 19:51001109-51001109	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.279G>A; p.A93A; 19:51000510-51000510	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.565C>T; p.H189Y; 19:51000059-51000059	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.565C>T; p.H189Y; 19:51000059-51000059	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation