lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1119
Symbol	CHKA
Synonymous	CHK\|CK\|CKI\|EK
Full name	choline kinase alpha
Gene description	CHETK-alpha\|ethanolamine kinase
Cytoband	11q13.2
Gene type	protein-coding
Synonymous	MIM:118491; HGNC:HGNC:1937; Ensembl:ENSG00000110721; HPRD:00327; Vega:OTTHUMG00000167424

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.458A>T; p.Q153L; 11:68097023-68097023	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.832C>T; p.L278F; 11:68070226-68070226	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1158C>T; p.F386F; 11:68064599-68064599	skin	malignant_melanoma	Substitution - coding silent
c.869+1G>A; p.?; 11:68070188-68070188	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1321G>A; p.A441T; 11:68054041-68054041	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1185T>C; p.T395T; 11:68064572-68064572	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.486C>T; p.S162S; 11:68081434-68081434	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.471T>C; p.C157C; 11:68081449-68081449	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.262C>T; p.R88W; 11:68120916-68120916	pancreas	carcinoma	Substitution - Missense
c.443A>G; p.Y148C; 11:68097038-68097038	breast	carcinoma	Substitution - Missense
c.1249C>A; p.H417N; 11:68062018-68062018	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.788T>C; p.I263T; 11:68070270-68070270	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1210G>A; p.E404K; 11:68064547-68064547	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.561C>T; p.L187L; 11:68074786-68074786	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1351C>T; p.Q451*; 11:68054011-68054011	skin; subungual	malignant_melanoma; acral_lentiginous	Substitution - Nonsense
c.1351C>T; p.Q451*; 11:68054011-68054011	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Nonsense
c.575T>G; p.L192R; 11:68074772-68074772	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.740A>C; p.K247T; 11:68070748-68070748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1193A>T; p.K398I; 11:68064564-68064564	ovary	other; neoplasm	Substitution - Missense
c.1347C>T; p.F449F; 11:68054015-68054015	skin	malignant_melanoma	Substitution - coding silent
c.328G>A; p.E110K; 11:68120850-68120850	urinary_tract; bladder	carcinoma	Substitution - Missense
c.993C>T; p.F331F; 11:68066452-68066452	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.430C>T; p.L144F; 11:68097051-68097051	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1158C>G; p.F386L; 11:68064599-68064599	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.638G>A; p.R213Q; 11:68070850-68070850	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>A; p.E163K; 11:68081433-68081433	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.487G>A; p.E163K; 11:68081433-68081433	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.802G>A; p.E268K; 11:68070256-68070256	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.809G>A; p.R270K; 11:68070249-68070249	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.261G>T; p.T87T; 11:68120917-68120917	thyroid	other; neoplasm	Substitution - coding silent
c.1334T>G; p.F445C; 11:68054028-68054028	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1224A>T; p.E408D; 11:68064533-68064533	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.866T>C; p.L289P; 11:68070192-68070192	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.609C>T; p.G203G; 11:68074738-68074738	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.981G>A; p.M327I; 11:68066464-68066464	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1201A>T; p.I401L; 11:68064556-68064556	liver	carcinoma	Substitution - Missense
c.525G>T; p.E175D; 11:68074822-68074822	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.615G>T; p.L205L; 11:68074732-68074732	liver	carcinoma	Substitution - coding silent
c.1202T>G; p.I401R; 11:68064555-68064555	large_intestine; rectum	NS	Substitution - Missense
c.293T>G; p.F98C; 11:68120885-68120885	skin	malignant_melanoma	Substitution - Missense
c.647C>T; p.T216I; 11:68070841-68070841	skin	malignant_melanoma	Substitution - Missense
c.618G>T; p.E206D; 11:68074729-68074729	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.972G>T; p.Q324H; 11:68066473-68066473	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.378G>C; p.Q126H; 11:68097103-68097103	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1099C>T; p.R367W; 11:68065812-68065812	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.827A>C; p.K276T; 11:68070231-68070231	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.543C>T; p.S181S; 11:68074804-68074804	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.799G>A; p.E267K; 11:68070259-68070259	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1113C>G; p.T371T; 11:68065798-68065798	breast	carcinoma	Substitution - coding silent
c.1079C>T; p.P360L; 11:68065832-68065832	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1079_1080insT; p.R363fs*27; 11:68065831-68065832	endometrium	carcinoma; serous_carcinoma	Insertion - Frameshift
c.1126-4delT; p.?; 11:68064635-68064635	stomach	adenocarcinoma	Unknown
c.1126-4delT; p.?; 11:68064635-68064635	stomach	adenocarcinoma	Unknown
c.785G>T; p.R262I; 11:68070273-68070273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1254C>T; p.F418F; 11:68062013-68062013	skin	malignant_melanoma	Substitution - coding silent
c.1196C>T; p.S399F; 11:68064561-68064561	skin	malignant_melanoma	Substitution - Missense
c.1031G>A; p.G344E; 11:68065880-68065880	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.390T>A; p.P130P; 11:68097091-68097091	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.705T>G; p.F235L; 11:68070783-68070783	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.436C>T; p.R146W; 11:68097045-68097045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.436C>T; p.R146W; 11:68097045-68097045	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1287G>T; p.K429N; 11:68061980-68061980	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.548T>C; p.M183T; 11:68074799-68074799	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1287G>T; p.K429N; 11:68061980-68061980	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1287G>T; p.K429N; 11:68061980-68061980	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.450G>A; p.A150A; 11:68097031-68097031	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.706C>T; p.H236Y; 11:68070782-68070782	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.706C>T; p.H236Y; 11:68070782-68070782	urinary_tract; bladder	carcinoma	Substitution - Missense
c.802G>T; p.E268*; 11:68070256-68070256	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1179C>G; p.L393L; 11:68064578-68064578	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation