lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	11178
Symbol	LZTS1
Synonymous	F37\|FEZ1
Full name	leucine zipper, putative tumor suppressor 1
Gene description	F37/Esophageal cancer-related gene-coding leucine-zipper motif\|leucine zipper putative tumor suppressor 1
Cytoband	8p22
Gene type	protein-coding
Synonymous	MIM:606551; HGNC:HGNC:13861; Ensembl:ENSG00000061337; HPRD:05945; Vega:OTTHUMG00000097027

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1249G>A; p.A417T; 8:20250264-20250264	pancreas	carcinoma	Substitution - Missense
c.1249G>A; p.A417T; 8:20250264-20250264	pancreas	carcinoma	Substitution - Missense
c.1249G>A; p.A417T; 8:20250264-20250264	pancreas	carcinoma	Substitution - Missense
c.1616T>G; p.V539G; 8:20249897-20249897	thyroid	other; neoplasm	Substitution - Missense
c.1743G>A; p.L581L; 8:20249770-20249770	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.885C>T; p.Y295Y; 8:20253046-20253046	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.885C>T; p.Y295Y; 8:20253046-20253046	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.801G>A; p.E267E; 8:20253130-20253130	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.873C>T; p.S291S; 8:20253058-20253058	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.187G>A; p.E63K; 8:20254995-20254995	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.898C>T; p.R300W; 8:20253033-20253033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.114C>T; p.S38S; 8:20255068-20255068	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.106C>T; p.R36W; 8:20255076-20255076	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.106C>T; p.R36W; 8:20255076-20255076	breast	carcinoma	Substitution - Missense
c.1702G>T; p.A568S; 8:20249811-20249811	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.411C>T; p.I137I; 8:20253520-20253520	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.409A>T; p.I137F; 8:20253522-20253522	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.116A>G; p.D39G; 8:20255066-20255066	breast	carcinoma	Substitution - Missense
c.1607A>C; p.K536T; 8:20249906-20249906	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1366C>T; p.R456C; 8:20250147-20250147	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.702C>T; p.D234D; 8:20253229-20253229	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1053C>T; p.S351S; 8:20252878-20252878	skin	malignant_melanoma	Substitution - coding silent
c.813G>T; p.L271F; 8:20253118-20253118	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1088T>A; p.L363H; 8:20252843-20252843	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.750G>A; p.S250S; 8:20253181-20253181	breast	carcinoma	Substitution - coding silent
c.969G>C; p.K323N; 8:20252962-20252962	urinary_tract; bladder	carcinoma	Substitution - Missense
c.969G>C; p.K323N; 8:20252962-20252962	urinary_tract; bladder	carcinoma	Substitution - Missense
c.186C>T; p.S62S; 8:20254996-20254996	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.186C>T; p.S62S; 8:20254996-20254996	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.253C>T; p.L85L; 8:20254929-20254929	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.253C>A; p.L85M; 8:20254929-20254929	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1555G>C; p.D519H; 8:20249958-20249958	breast	carcinoma	Substitution - Missense
c.77G>A; p.R26H; 8:20255105-20255105	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1413_1414GG>TT; p.L471>?; 8:20250099-20250100	lung	carcinoma; adenocarcinoma	Complex
c.775G>T; p.D259Y; 8:20253156-20253156	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1169A>G; p.E390G; 8:20250344-20250344	skin	malignant_melanoma	Substitution - Missense
c.415C>A; p.H139N; 8:20253516-20253516	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1000C>T; p.Q334*; 8:20252931-20252931	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1000C>T; p.Q334*; 8:20252931-20252931	large_intestine; colon	carcinoma	Substitution - Nonsense
c.62C>T; p.S21L; 8:20255120-20255120	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1650C>T; p.Y550Y; 8:20249863-20249863	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.905_919del15; p.C302_E307>*; 8:20253012-20253026	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Complex - deletion inframe
c.678C>T; p.S226S; 8:20253253-20253253	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1667G>A; p.R556Q; 8:20249846-20249846	pancreas	carcinoma	Substitution - Missense
c.756C>A; p.V252V; 8:20253175-20253175	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.292T>G; p.F98V; 8:20254890-20254890	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.565A>T; p.S189C; 8:20253366-20253366	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.334C>G; p.Q112E; 8:20254848-20254848	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1265C>T; p.T422M; 8:20250248-20250248	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1265C>T; p.T422M; 8:20250248-20250248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1423C>G; p.L475V; 8:20250090-20250090	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1719C>T; p.A573A; 8:20249794-20249794	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1471C>T; p.P491S; 8:20250042-20250042	liver	carcinoma	Substitution - Missense
c.1471C>T; p.P491S; 8:20250042-20250042	liver	carcinoma	Substitution - Missense
c.963G>A; p.S321S; 8:20252968-20252968	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.939C>T; p.G313G; 8:20252992-20252992	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1761C>T; p.P587P; 8:20249752-20249752	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1048G>T; p.E350*; 8:20252883-20252883	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1576C>A; p.Q526K; 8:20249937-20249937	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.880G>A; p.A294T; 8:20253051-20253051	stomach	adenocarcinoma	Substitution - Missense
c.1276C>T; p.L426L; 8:20250237-20250237	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.768C>A; p.I256I; 8:20253163-20253163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1666C>T; p.R556W; 8:20249847-20249847	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1128G>A; p.A376A; 8:20252803-20252803	liver	carcinoma	Substitution - coding silent
c.263G>T; p.G88V; 8:20254919-20254919	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1056_1057CA>GT; p.M353L; 8:20252874-20252875	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1569G>C; p.S523S; 8:20249944-20249944	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.118G>A; p.G40R; 8:20255064-20255064	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.299C>T; p.P100L; 8:20254883-20254883	pancreas	carcinoma	Substitution - Missense
c.438C>T; p.S146S; 8:20253493-20253493	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.981G>A; p.A327A; 8:20252950-20252950	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.981G>A; p.A327A; 8:20252950-20252950	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1047C>T; p.L349L; 8:20252884-20252884	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.114C>G; p.S38S; 8:20255068-20255068	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1119C>T; p.F373F; 8:20252812-20252812	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.574C>G; p.Q192E; 8:20253357-20253357	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1597A>G; p.K533E; 8:20249916-20249916	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.509C>T; p.A170V; 8:20253422-20253422	breast	carcinoma	Substitution - Missense
c.1790G>A; p.597; 8:20249723-20249723	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1135G>C; p.E379Q; 8:20252796-20252796	breast	carcinoma	Substitution - Missense
c.311C>A; p.P104H; 8:20254871-20254871	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1367G>A; p.R456H; 8:20250146-20250146	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1504C>T; p.R502W; 8:20250009-20250009	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.63G>A; p.S21S; 8:20255119-20255119	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1543C>A; p.R515R; 8:20249970-20249970	thyroid	other; neoplasm	Substitution - coding silent
c.1331G>T; p.G444V; 8:20250182-20250182	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.977G>A; p.R326H; 8:20252954-20252954	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1106A>G; p.E369G; 8:20252825-20252825	liver	carcinoma	Substitution - Missense
c.1142A>G; p.Q381R; 8:20252789-20252789	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1126G>C; p.A376P; 8:20252805-20252805	liver	carcinoma	Substitution - Missense
c.1126G>C; p.A376P; 8:20252805-20252805	liver	carcinoma	Substitution - Missense
c.1716C>T; p.S572S; 8:20249797-20249797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.886G>A; p.E296K; 8:20253045-20253045	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.171C>G; p.S57S; 8:20255011-20255011	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.886G>A; p.E296K; 8:20253045-20253045	urinary_tract; bladder	carcinoma	Substitution - Missense
c.171C>G; p.S57S; 8:20255011-20255011	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.30C>T; p.G10G; 8:20255152-20255152	breast	carcinoma	Substitution - coding silent
c.1729T>C; p.L577L; 8:20249784-20249784	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.1315G>A; p.A439T; 8:20250198-20250198	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.661G>T; p.D221Y; 8:20253270-20253270	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.597C>A; p.P199P; 8:20253334-20253334	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.845G>A; p.R282H; 8:20253086-20253086	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.448C>T; p.H150Y; 8:20253483-20253483	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.300G>A; p.P100P; 8:20254882-20254882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1568C>T; p.S523L; 8:20249945-20249945	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1127C>T; p.A376V; 8:20252804-20252804	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.758G>A; p.R253H; 8:20253173-20253173	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.265G>A; p.D89N; 8:20254917-20254917	skin	malignant_melanoma	Substitution - Missense
c.980C>T; p.A327V; 8:20252951-20252951	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.926C>T; p.P309L; 8:20253005-20253005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.926C>T; p.P309L; 8:20253005-20253005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1013T>A; p.L338H; 8:20252918-20252918	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.540C>T; p.S180S; 8:20253391-20253391	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.899G>A; p.R300Q; 8:20253032-20253032	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1084A>T; p.K362*; 8:20252847-20252847	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1198delG; p.E400fs*6; 8:20250315-20250315	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.196T>C; p.F66L; 8:20254986-20254986	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.196T>C; p.F66L; 8:20254986-20254986	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1314C>T; p.G438G; 8:20250199-20250199	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1314C>T; p.G438G; 8:20250199-20250199	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1209G>A; p.T403T; 8:20250304-20250304	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.628G>A; p.A210T; 8:20253303-20253303	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1020_1021GG>TT; p.Q340_E341>H*; 8:20252910-20252911	lung; right_upper_lobe	carcinoma; adenocarcinoma	Complex - compound substitution
c.1528G>A; p.E510K; 8:20249985-20249985	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.902G>A; p.R301H; 8:20253029-20253029	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.537G>C; p.M179I; 8:20253394-20253394	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1777G>T; p.A593S; 8:20249736-20249736	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.338T>C; p.L113P; 8:20254844-20254844	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.338T>C; p.L113P; 8:20254844-20254844	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.338T>C; p.L113P; 8:20254844-20254844	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.338T>C; p.L113P; 8:20254844-20254844	soft_tissue; fibrous_tissue_and_uncertain_o	gastrointestinal_stromal_tumour	Substitution - Missense
c.231C>T; p.S77S; 8:20254951-20254951	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - coding silent
c.726G>A; p.S242S; 8:20253205-20253205	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.231C>T; p.S77S; 8:20254951-20254951	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - coding silent
c.231C>T; p.S77S; 8:20254951-20254951	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - coding silent
c.1174T>C; p.S392P; 8:20250339-20250339	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.292T>A; p.F98I; 8:20254890-20254890	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.261C>T; p.S87S; 8:20254921-20254921	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.261C>T; p.S87S; 8:20254921-20254921	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.261C>T; p.S87S; 8:20254921-20254921	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.261C>T; p.S87S; 8:20254921-20254921	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.261C>T; p.S87S; 8:20254921-20254921	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.298C>T; p.P100S; 8:20254884-20254884	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.298C>T; p.P100S; 8:20254884-20254884	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.698C>T; p.S233F; 8:20253233-20253233	skin	malignant_melanoma	Substitution - Missense
c.156C>T; p.H52H; 8:20255026-20255026	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.778G>A; p.E260K; 8:20253153-20253153	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.598G>A; p.V200M; 8:20253333-20253333	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1295G>T; p.R432M; 8:20250218-20250218	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1252C>A; p.Q418K; 8:20250261-20250261	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation