lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1116
Symbol	CHI3L1
Synonymous	ASRT7\|CGP-39\|GP-39\|GP39\|HC-gp39\|HCGP-3P\|YKL-40\|YKL40\|YYL-40\|hCGP-39
Full name	chitinase 3-like 1 (cartilage glycoprotein-39)
Gene description	39 kDa synovial protein\|cartilage glycoprotein 39\|chitinase-3-like protein 1
Cytoband	1q32.1
Gene type	protein-coding
Synonymous	MIM:601525; HGNC:HGNC:1932; Ensembl:ENSG00000133048; HPRD:03314; Vega:OTTHUMG00000042122

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.744G>T; p.G248G; 1:203180620-203180620	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.985G>A; p.D329N; 1:203179787-203179787	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.851C>T; p.P284L; 1:203180513-203180513	skin	malignant_melanoma	Substitution - Missense
c.112G>A; p.D38N; 1:203185329-203185329	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1039G>A; p.A347T; 1:203179558-203179558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.341A>G; p.Q114R; 1:203183765-203183765	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.853G>A; p.G285S; 1:203180511-203180511	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.980G>C; p.G327A; 1:203179792-203179792	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.142C>A; p.R48S; 1:203185299-203185299	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1098G>T; p.Q366H; 1:203179499-203179499	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.487A>G; p.K163E; 1:203182831-203182831	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.913G>A; p.G305R; 1:203179859-203179859	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.619G>A; p.D207N; 1:203181254-203181254	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.579G>T; p.K193N; 1:203182739-203182739	ovary	carcinoma; adenocarcinoma	Substitution - Missense
c.579G>T; p.K193N; 1:203182739-203182739	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.379C>G; p.L127V; 1:203183727-203183727	breast	carcinoma	Substitution - Missense
c.379C>G; p.L127V; 1:203183727-203183727	breast	carcinoma	Substitution - Missense
c.478G>A; p.E160K; 1:203182840-203182840	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.383G>A; p.R128H; 1:203183723-203183723	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.89G>T; p.S30I; 1:203185352-203185352	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.867G>A; p.K289K; 1:203180497-203180497	skin	malignant_melanoma	Substitution - coding silent
c.478G>A; p.E160K; 1:203182840-203182840	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.199G>C; p.D67H; 1:203185242-203185242	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.679G>A; p.E227K; 1:203181194-203181194	skin	malignant_melanoma	Substitution - Missense
c.729C>T; p.Y243Y; 1:203180635-203180635	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.225G>A; p.T75T; 1:203185216-203185216	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.54C>T; p.C18C; 1:203186317-203186317	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.346C>T; p.R116C; 1:203183760-203183760	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1006A>C; p.S336R; 1:203179766-203179766	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.855_856CC>AT; p.R286W; 1:203180508-203180509	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.857G>A; p.R286Q; 1:203180507-203180507	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.911G>A; p.R304H; 1:203179861-203179861	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.338_339CC>TT; p.T113I; 1:203183767-203183768	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1102C>G; p.L368V; 1:203179495-203179495	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1040C>T; p.A347V; 1:203179557-203179557	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1079A>T; p.Q360L; 1:203179518-203179518	liver	carcinoma	Substitution - Missense
c.1079A>T; p.Q360L; 1:203179518-203179518	liver	carcinoma	Substitution - Missense
c.495C>G; p.A165A; 1:203182823-203182823	prostate	adenoma	Substitution - coding silent
c.225_226insG; p.L76fs*58; 1:203185215-203185216	breast	carcinoma	Insertion - Frameshift
c.674G>A; p.G225D; 1:203181199-203181199	skin	malignant_melanoma	Substitution - Missense
c.968A>T; p.N323I; 1:203179804-203179804	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>A; p.D199N; 1:203181278-203181278	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.468A>G; p.E156E; 1:203182850-203182850	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.223A>T; p.T75S; 1:203185218-203185218	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.431G>A; p.R144Q; 1:203183675-203183675	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1093G>C; p.G365R; 1:203179504-203179504	thyroid	carcinoma	Substitution - Missense
c.906C>T; p.F302F; 1:203179866-203179866	skin	malignant_melanoma	Substitution - coding silent
c.1092T>C; p.C364C; 1:203179505-203179505	thyroid	other; neoplasm	Substitution - coding silent
c.191A>G; p.D64G; 1:203185250-203185250	pancreas	carcinoma	Substitution - Missense
c.600C>T; p.F200F; 1:203181273-203181273	skin	malignant_melanoma	Substitution - coding silent
c.332C>T; p.S111F; 1:203183774-203183774	skin	malignant_melanoma	Substitution - Missense
c.837A>C; p.S279S; 1:203180527-203180527	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2T>C; p.M1T; 1:203186622-203186622	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.525C>T; p.S175S; 1:203182793-203182793	breast	carcinoma	Substitution - coding silent
c.458T>C; p.L153P; 1:203183648-203183648	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.994G>A; p.E332K; 1:203179778-203179778	skin	malignant_melanoma	Substitution - Missense
c.258-2A>C; p.?; 1:203184634-203184634	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.817G>A; p.G273S; 1:203180547-203180547	liver	carcinoma	Substitution - Missense
c.783C>T; p.F261F; 1:203180581-203180581	pancreas	carcinoma	Substitution - coding silent
c.927T>C; p.H309H; 1:203179845-203179845	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.783C>T; p.F261F; 1:203180581-203180581	skin; arm	malignant_melanoma	Substitution - coding silent
c.139G>A; p.D47N; 1:203185302-203185302	breast	carcinoma	Substitution - Missense
c.454A>C; p.T152P; 1:203183652-203183652	breast	carcinoma	Substitution - Missense
c.371C>T; p.P124L; 1:203183735-203183735	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.111C>T; p.G37G; 1:203185330-203185330	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011G>A; p.K337K; 1:203179761-203179761	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - coding silent
c.1131G>A; p.K377K; 1:203179466-203179466	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1131G>A; p.K377K; 1:203179466-203179466	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1001T>C; p.V334A; 1:203179771-203179771	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.912C>T; p.R304R; 1:203179860-203179860	soft_tissue; blood_vessel	angiosarcoma	Substitution - coding silent
c.910C>T; p.R304C; 1:203179862-203179862	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>C; p.W212C; 1:203181237-203181237	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.828C>T; p.A276A; 1:203180536-203180536	breast	carcinoma	Substitution - coding silent
c.113A>T; p.D38V; 1:203185328-203185328	breast	carcinoma	Substitution - Missense
c.999C>G; p.S333R; 1:203179773-203179773	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.988G>A; p.D330N; 1:203179784-203179784	skin	malignant_melanoma	Substitution - Missense
c.988G>A; p.D330N; 1:203179784-203179784	skin	malignant_melanoma	Substitution - Missense
c.988G>A; p.D330N; 1:203179784-203179784	skin	malignant_melanoma	Substitution - Missense
c.12G>T; p.K4N; 1:203186612-203186612	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.640G>A; p.G214R; 1:203181233-203181233	skin	malignant_melanoma	Substitution - Missense
c.426T>C; p.P142P; 1:203183680-203183680	liver	carcinoma	Substitution - coding silent
c.673G>A; p.G225S; 1:203181200-203181200	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1099G>A; p.D367N; 1:203179498-203179498	skin	malignant_melanoma	Substitution - Missense
c.217G>A; p.D73N; 1:203185224-203185224	breast	carcinoma	Substitution - Missense
c.372G>A; p.P124P; 1:203183734-203183734	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.372G>A; p.P124P; 1:203183734-203183734	breast	carcinoma	Substitution - coding silent
c.231C>T; p.Y77Y; 1:203185210-203185210	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1091G>A; p.C364Y; 1:203179506-203179506	liver	carcinoma	Substitution - Missense
c.1091G>A; p.C364Y; 1:203179506-203179506	liver	carcinoma	Substitution - Missense
c.231C>T; p.Y77Y; 1:203185210-203185210	breast	carcinoma	Substitution - coding silent
c.331T>G; p.S111A; 1:203183775-203183775	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.725G>A; p.G242E; 1:203180639-203180639	skin	malignant_melanoma	Substitution - Missense
c.282G>C; p.L94F; 1:203184608-203184608	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.234C>G; p.G78G; 1:203185207-203185207	breast	carcinoma	Substitution - coding silent
c.502G>T; p.G168W; 1:203182816-203182816	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.213G>T; p.W71C; 1:203185228-203185228	pancreas	NS	Substitution - Missense
c.213G>T; p.W71C; 1:203185228-203185228	pancreas	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation