lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1113
Symbol	CHGA
Synonymous	CGA
Full name	chromogranin A
Gene description	SP-I\|betagranin (N-terminal fragment of chromogranin A)\|catestatin\|chromofungin\|chromogranin-A\|parathyroid secretory protein 1\|pituitary secretory protein I
Cytoband	14q32
Gene type	protein-coding
Synonymous	MIM:118910; HGNC:HGNC:1929; Ensembl:ENSG00000100604; HPRD:07170; Vega:OTTHUMG00000171225

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.250C>T; p.L84F; 14:92927612-92927612	skin	malignant_melanoma	Substitution - Missense
c.707A>C; p.E236A; 14:92931601-92931601	liver	carcinoma	Substitution - Missense
c.1181G>A; p.W394*; 14:92932742-92932742	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.277C>T; p.Q93*; 14:92929737-92929737	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.277C>T; p.Q93*; 14:92929737-92929737	thyroid	carcinoma; papillary_carcinoma	Substitution - Nonsense
c.1174C>T; p.R392*; 14:92932735-92932735	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.816G>A; p.S272S; 14:92932377-92932377	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.816G>A; p.S272S; 14:92932377-92932377	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.53C>T; p.A18V; 14:92924205-92924205	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.430G>A; p.E144K; 14:92931324-92931324	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.84G>A; p.G28G; 14:92924236-92924236	skin	malignant_melanoma	Substitution - coding silent
c.1264G>A; p.E422K; 14:92932825-92932825	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1264G>A; p.E422K; 14:92932825-92932825	large_intestine; colon	carcinoma	Substitution - Missense
c.715G>C; p.A239P; 14:92931609-92931609	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.135C>A; p.S45S; 14:92926646-92926646	breast	carcinoma	Substitution - coding silent
c.11C>T; p.A4V; 14:92923370-92923370	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.825G>A; p.L275L; 14:92932386-92932386	skin	malignant_melanoma	Substitution - coding silent
c.520_522delGAG; p.E174delE; 14:92931414-92931416	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - In frame
c.520_522delGAG; p.E174delE; 14:92931414-92931416	breast	carcinoma	Deletion - In frame
c.520_522delGAG; p.E174delE; 14:92931414-92931416	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.443G>A; p.G148E; 14:92931337-92931337	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.228G>A; p.L76L; 14:92927590-92927590	skin	malignant_melanoma	Substitution - coding silent
c.159C>G; p.S53R; 14:92926670-92926670	skin	malignant_melanoma	Substitution - Missense
c.625G>A; p.G209S; 14:92931519-92931519	thyroid	other; neoplasm	Substitution - Missense
c.687G>A; p.E229E; 14:92931581-92931581	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.687G>A; p.E229E; 14:92931581-92931581	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.602G>A; p.G201E; 14:92931496-92931496	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.212G>T; p.R71I; 14:92927574-92927574	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.212G>T; p.R71I; 14:92927574-92927574	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1059G>A; p.T353T; 14:92932620-92932620	skin	malignant_melanoma	Substitution - coding silent
c.1231G>A; p.V411I; 14:92932792-92932792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.976G>A; p.E326K; 14:92932537-92932537	small_intestine	carcinoid-endocrine_tumour	Substitution - Missense
c.122C>A; p.S41Y; 14:92926633-92926633	skin; mucosal	malignant_melanoma	Substitution - Missense
c.215A>T; p.H72L; 14:92927577-92927577	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1193C>A; p.S398Y; 14:92932754-92932754	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.877G>C; p.G293R; 14:92932438-92932438	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.919G>A; p.E307K; 14:92932480-92932480	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.545A>G; p.N182S; 14:92931439-92931439	skin	malignant_melanoma	Substitution - Missense
c.539C>T; p.A180V; 14:92931433-92931433	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1095G>C; p.E365D; 14:92932656-92932656	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.279G>A; p.Q93Q; 14:92929739-92929739	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1003G>A; p.E335K; 14:92932564-92932564	pancreas	carcinoma	Substitution - Missense
c.1003G>A; p.E335K; 14:92932564-92932564	pancreas	carcinoma	Substitution - Missense
c.1193C>T; p.S398F; 14:92932754-92932754	skin	malignant_melanoma	Substitution - Missense
c.134C>T; p.S45F; 14:92926645-92926645	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.294C>T; p.S98S; 14:92929754-92929754	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.685_686insGAG; p.E228_E229insG; 14:92931579-92931580	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - In frame
c.792G>T; p.E264D; 14:92931686-92931686	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.95T>C; p.V32A; 14:92926606-92926606	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.442G>A; p.G148R; 14:92931336-92931336	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.442G>A; p.G148R; 14:92931336-92931336	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.360G>A; p.A120A; 14:92931254-92931254	breast	carcinoma	Substitution - coding silent
c.442G>A; p.G148R; 14:92931336-92931336	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.738_739GG>AA; p.E247K; 14:92931632-92931633	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.388A>G; p.M130V; 14:92931282-92931282	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.608G>C; p.S203T; 14:92931502-92931502	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.110T>C; p.V37A; 14:92926621-92926621	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.436A>G; p.T146A; 14:92931330-92931330	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1298A>T; p.E433V; 14:92934808-92934808	skin; leg	malignant_melanoma; superficial_spreading	Substitution - Missense
c.613G>A; p.G205S; 14:92931507-92931507	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.703G>A; p.E235K; 14:92931597-92931597	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	Substitution - Missense
c.398G>T; p.R133I; 14:92931292-92931292	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.692A>C; p.E231A; 14:92931586-92931586	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.684_685insGAG; p.E236_A237insE; 14:92931578-92931579	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - In frame
c.259G>A; p.A87T; 14:92929719-92929719	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1367_1368GG>AA; p.R456Q; 14:92934877-92934878	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.873C>T; p.P291P; 14:92932434-92932434	pancreas	carcinoma	Substitution - coding silent
c.995T>C; p.L332P; 14:92932556-92932556	thyroid	other; neoplasm	Substitution - Missense
c.124G>A; p.D42N; 14:92926635-92926635	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.807G>C; p.E269D; 14:92931701-92931701	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1050G>T; p.K350N; 14:92932611-92932611	skin	malignant_melanoma	Substitution - Missense
c.173A>G; p.E58G; 14:92926684-92926684	skin	malignant_melanoma	Substitution - Missense
c.1323A>G; p.E441E; 14:92934833-92934833	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1323A>G; p.E441E; 14:92934833-92934833	thyroid	other; neoplasm	Substitution - coding silent
c.96G>A; p.V32V; 14:92926607-92926607	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.382G>C; p.D128H; 14:92931276-92931276	ovary	other; neoplasm	Substitution - Missense
c.232G>A; p.E78K; 14:92927594-92927594	skin	malignant_melanoma	Substitution - Missense
c.1134C>A; p.A378A; 14:92932695-92932695	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.54G>A; p.A18A; 14:92924206-92924206	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.54G>A; p.A18A; 14:92924206-92924206	breast	carcinoma	Substitution - coding silent
c.817G>C; p.E273Q; 14:92932378-92932378	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.817G>C; p.E273Q; 14:92932378-92932378	urinary_tract; bladder	carcinoma	Substitution - Missense
c.730G>T; p.V244F; 14:92931624-92931624	thyroid	other; neoplasm	Substitution - Missense
c.1366C>T; p.R456W; 14:92934876-92934876	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>A; p.G240R; 14:92931612-92931612	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation