Cancer metastasis database

Annotation category 5

Gene information

Gene ID 11012
Symbol

KLK11

Synonymous

PRSS20|TLSP

Full name

kallikrein-related peptidase 11

Gene description

hK11|hippostasin|kallikrein 11|kallikrein-11|serine protease 20|trypsin-like protease

Cytoband

19q13.33

Gene type

protein-coding

Synonymous

MIM:604434; HGNC:HGNC:6359; Ensembl:ENSG00000167757; HPRD:05114; Vega:OTTHUMG00000182915

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.216C>T; p.F72F; 19:51024715-51024715

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.847T>G; p.*283E; 19:51022547-51022547

 lungcarcinoma; adenocarcinomaNonstop extension

c.199T>C; p.W67R; 19:51024732-51024732

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.77G>A; p.R26H; 19:51025651-51025651

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.318G>T; p.Q106H; 19:51024286-51024286

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.332A>C; p.K111T; 19:51024272-51024272

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.492C>T; p.S164S; 19:51024112-51024112

 skinmalignant_melanomaSubstitution - coding silent

c.403C>T; p.P135S; 19:51024201-51024201

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.551G>A; p.S184N; 19:51024053-51024053

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.706G>A; p.G236R; 19:51022688-51022688

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.643A>C; p.T215P; 19:51023145-51023145

 central_nervous_system; brainglioma; oligoastrocytoma_Grade_IIISubstitution - Missense

c.33G>C; p.K11N; 19:51027485-51027485

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.25G>T; p.D9Y; 19:51027493-51027493

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.80C>T; p.S27F; 19:51025648-51025648

 breastcarcinomaSubstitution - Missense

c.348G>T; p.E116D; 19:51024256-51024256

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.761A>T; p.D254V; 19:51022633-51022633

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.651C>A; p.T217T; 19:51023137-51023137

 pancreascarcinomaSubstitution - coding silent

c.651C>A; p.T217T; 19:51023137-51023137

 pancreascarcinomaSubstitution - coding silent

c.294-9C>A; p.?; 19:51024319-51024319

 ovarycarcinoma; serous_carcinomaUnknown

c.660T>C; p.C220C; 19:51023128-51023128

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.689C>T; p.S230F; 19:51023099-51023099

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.307C>T; p.H103Y; 19:51024297-51024297

 skinmalignant_melanomaSubstitution - Missense

c.307C>T; p.H103Y; 19:51024297-51024297

 breastcarcinomaSubstitution - Missense

c.238G>A; p.G80R; 19:51024693-51024693

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.40G>A; p.G14S; 19:51027478-51027478

 skinmalignant_melanomaSubstitution - Missense

c.710_711insG; p.L239fs*4; 19:51022683-51022684

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaInsertion - Frameshift

c.385G>A; p.G129S; 19:51024219-51024219

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.732T>C; p.S244S; 19:51022662-51022662

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.822G>C; p.W274C; 19:51022572-51022572

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.765G>A; p.P255P; 19:51022629-51022629

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.89T>C; p.L30P; 19:51025639-51025639

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.327C>A; p.L109L; 19:51024277-51024277

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.725A>G; p.N242S; 19:51022669-51022669

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.739G>A; p.G247S; 19:51022655-51022655

 skin; trunkmalignant_melanoma; nodularSubstitution - Missense

c.252C>T; p.I84I; 19:51024679-51024679

 skinmalignant_melanomaSubstitution - coding silent

c.174C>T; p.F58F; 19:51024757-51024757

 skinmalignant_melanomaSubstitution - coding silent

c.145G>A; p.G49R; 19:51024786-51024786

 skinmalignant_melanomaSubstitution - Missense

c.224C>T; p.T75M; 19:51024707-51024707

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.604G>C; p.E202Q; 19:51023184-51023184

 breastcarcinomaSubstitution - Missense

c.432G>A; p.M144I; 19:51024172-51024172

 pancreascarcinomaSubstitution - Missense

c.671A>G; p.Q224R; 19:51023117-51023117

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.449C>T; p.S150L; 19:51024155-51024155

 skinmalignant_melanomaSubstitution - Missense

c.264G>A; p.W88*; 19:51024667-51024667

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.147G>A; p.G49G; 19:51024784-51024784

 skinmalignant_melanomaSubstitution - coding silent

c.710delG; p.G237fs*43; 19:51022684-51022684

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.770C>T; p.A257V; 19:51022624-51022624

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.545C>T; p.T182M; 19:51024059-51024059

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.356G>A; p.R119Q; 19:51024248-51024248

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.293C>T; p.P98L; 19:51024638-51024638

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.141T>C; p.L47L; 19:51024790-51024790

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.187C>T; p.H63Y; 19:51024744-51024744

 breastcarcinomaSubstitution - Missense

c.662C>T; p.A221V; 19:51023126-51023126

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.693C>A; p.C231*; 19:51023095-51023095

 breastcarcinomaSubstitution - Nonsense

c.528T>A; p.I176I; 19:51024076-51024076

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.796A>C; p.T266P; 19:51022598-51022598

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.733C>T; p.L245F; 19:51022661-51022661

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.779G>A; p.R260Q; 19:51022615-51022615

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense