lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10988
Symbol	METAP2
Synonymous	MAP2\|MNPEP\|p67\|p67eIF2
Full name	methionyl aminopeptidase 2
Gene description	MAP 2\|eIF-2-associated p67 homolog\|initiation factor 2-associated 67 kDa glycoprotein\|metAP 2\|methionine aminopeptidase 2\|p67\|p67eIF2\|peptidase M 2
Cytoband	12q22
Gene type	protein-coding
Synonymous	MIM:601870; HGNC:HGNC:16672; Ensembl:ENSG00000111142; HPRD:03522; Vega:OTTHUMG00000170280

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.236A>C; p.K79T; 12:95476155-95476155	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1189C>T; p.P397S; 12:95513656-95513656	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.990A>G; p.G330G; 12:95511920-95511920	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1264C>T; p.R422C; 12:95513731-95513731	skin	malignant_melanoma	Substitution - Missense
c.434C>G; p.T145R; 12:95494061-95494061	skin	malignant_melanoma	Substitution - Missense
c.223G>A; p.A75T; 12:95476142-95476142	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1163A>T; p.D388V; 12:95512895-95512895	prostate	carcinoma	Substitution - Missense
c.189A>G; p.S63S; 12:95476108-95476108	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1150A>G; p.M384V; 12:95512882-95512882	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.508C>T; p.R170*; 12:95494135-95494135	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.22G>A; p.A8T; 12:95474201-95474201	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.22G>A; p.A8T; 12:95474201-95474201	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.22G>A; p.A8T; 12:95474201-95474201	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.22G>A; p.A8T; 12:95474201-95474201	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.22G>A; p.A8T; 12:95474201-95474201	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.22G>A; p.A8T; 12:95474201-95474201	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.22G>A; p.A8T; 12:95474201-95474201	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.730T>C; p.Y244H; 12:95495096-95495096	urinary_tract; bladder	carcinoma	Substitution - Missense
c.767T>C; p.I256T; 12:95495133-95495133	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.821A>G; p.D274G; 12:95496052-95496052	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.901G>A; p.G301S; 12:95504098-95504098	skin	malignant_melanoma	Substitution - Missense
c.400G>T; p.E134*; 12:95485953-95485953	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1250G>A; p.R417H; 12:95513717-95513717	urinary_tract; bladder	carcinoma	Substitution - Missense
c.121_123delAAG; p.K44delK; 12:95474300-95474302	peritoneum; appendix	other; pseudomyxoma_peritonei	Deletion - In frame
c.193G>A; p.D65N; 12:95476112-95476112	skin	malignant_melanoma	Substitution - Missense
c.1290G>T; p.M430I; 12:95513757-95513757	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.562A>G; p.K188E; 12:95494189-95494189	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.123G>A; p.K41K; 12:95474302-95474302	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.592G>T; p.E198*; 12:95494958-95494958	breast	carcinoma	Substitution - Nonsense
c.1423G>C; p.G475R; 12:95513890-95513890	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.868-9delT; p.?; 12:95504056-95504056	stomach	adenocarcinoma	Unknown
c.430C>T; p.R144*; 12:95494057-95494057	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1159T>G; p.F387V; 12:95512891-95512891	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.995C>A; p.S332*; 12:95511925-95511925	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.757G>T; p.G253*; 12:95495123-95495123	breast	carcinoma	Substitution - Nonsense
c.1238T>C; p.L413P; 12:95513705-95513705	bone; femur	chondrosarcoma	Substitution - Missense
c.1238T>C; p.L413P; 12:95513705-95513705	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.967A>T; p.K323*; 12:95511897-95511897	breast	carcinoma	Substitution - Nonsense
c.615C>T; p.R205R; 12:95494981-95494981	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.758G>T; p.G253V; 12:95495124-95495124	breast	carcinoma	Substitution - Missense
c.809A>T; p.N270I; 12:95496040-95496040	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.456T>C; p.S152S; 12:95494083-95494083	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.367C>A; p.L123M; 12:95485920-95485920	skin	malignant_melanoma	Substitution - Missense
c.463A>C; p.K155Q; 12:95494090-95494090	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.9T>G; p.G3G; 12:95474188-95474188	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.9T>G; p.G3G; 12:95474188-95474188	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.9T>G; p.G3G; 12:95474188-95474188	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.20T>A; p.V7E; 12:95474199-95474199	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.908C>T; p.A303V; 12:95504105-95504105	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.328A>G; p.K110E; 12:95485881-95485881	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.343C>T; p.P115S; 12:95485896-95485896	skin	malignant_melanoma	Substitution - Missense
c.1095C>A; p.T365T; 12:95512827-95512827	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.94G>C; p.E32Q; 12:95474273-95474273	urinary_tract; bladder	carcinoma	Substitution - Missense
c.406G>A; p.E136K; 12:95485959-95485959	liver	carcinoma	Substitution - Missense
c.94G>C; p.E32Q; 12:95474273-95474273	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.473T>C; p.L158S; 12:95494100-95494100	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1124A>G; p.H375R; 12:95512856-95512856	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.384A>G; p.V128V; 12:95485937-95485937	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1195A>G; p.T399A; 12:95513662-95513662	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1368G>A; p.A456A; 12:95513835-95513835	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.910A>G; p.I304V; 12:95504107-95504107	liver	carcinoma	Substitution - Missense
c.1368G>A; p.A456A; 12:95513835-95513835	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.910A>G; p.I304V; 12:95504107-95504107	liver	carcinoma	Substitution - Missense
c.591-2A>T; p.?; 12:95494955-95494955	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation