lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10643
Symbol	IGF2BP3
Synonymous	CT98\|IMP-3\|IMP3\|KOC\|KOC1\|VICKZ3
Full name	insulin-like growth factor 2 mRNA binding protein 3
Gene description	IGF-II mRNA-binding protein 3\|IGF2 mRNA-binding protein 3\|KH domain containing protein overexpressed in cancer\|VICKZ family member 3\|cancer/testis antigen 98\|insulin-like growth factor 2 mRNA-binding protein 3
Cytoband	7p11
Gene type	protein-coding
Synonymous	MIM:608259; HGNC:HGNC:28868; Ensembl:ENSG00000136231; HPRD:16306; Vega:OTTHUMG00000128445

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.307C>T; p.Q103*; 7:23361720-23361720	skin	malignant_melanoma	Substitution - Nonsense
c.567C>A; p.S189S; 7:23351421-23351421	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.114C>G; p.G38G; 7:23469997-23469997	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.490C>A; p.P164T; 7:23351498-23351498	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.687C>T; p.I229I; 7:23347731-23347731	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1265G>A; p.G422D; 7:23319193-23319193	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1352T>G; p.V451G; 7:23317682-23317682	breast	carcinoma	Substitution - Missense
c.1158C>T; p.T386T; 7:23342109-23342109	liver	carcinoma	Substitution - coding silent
c.1158C>T; p.T386T; 7:23342109-23342109	liver	carcinoma	Substitution - coding silent
c.539C>T; p.S180L; 7:23351449-23351449	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.310T>C; p.Y104H; 7:23361717-23361717	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.905T>A; p.I302N; 7:23345976-23345976	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.257G>A; p.R86Q; 7:23418804-23418804	skin	malignant_melanoma	Substitution - Missense
c.257G>A; p.R86Q; 7:23418804-23418804	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.680C>G; p.S227C; 7:23351308-23351308	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1704T>A; p.A568A; 7:23312398-23312398	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.489C>A; p.N163K; 7:23351499-23351499	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1332G>A; p.A444A; 7:23317702-23317702	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1332G>A; p.A444A; 7:23317702-23317702	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1332G>A; p.A444A; 7:23317702-23317702	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.562G>A; p.V188I; 7:23351426-23351426	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1220C>G; p.T407S; 7:23319238-23319238	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1573C>T; p.R525C; 7:23312803-23312803	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.87G>T; p.V29V; 7:23470024-23470024	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1726T>A; p.S576T; 7:23312376-23312376	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1414G>T; p.G472*; 7:23313635-23313635	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.956C>A; p.T319K; 7:23343839-23343839	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.435G>A; p.E145E; 7:23351553-23351553	breast	carcinoma	Substitution - coding silent
c.710C>T; p.A237V; 7:23347708-23347708	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.152T>C; p.L51P; 7:23469959-23469959	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.898A>T; p.K300*; 7:23345983-23345983	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.542G>A; p.R181K; 7:23351446-23351446	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.542G>A; p.R181K; 7:23351446-23351446	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.977C>A; p.T326N; 7:23343818-23343818	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1051T>A; p.Y351N; 7:23343744-23343744	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.892A>C; p.N298H; 7:23345989-23345989	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.739C>T; p.L247F; 7:23347679-23347679	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.352G>A; p.E118K; 7:23361583-23361583	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1677G>A; p.Q559Q; 7:23312425-23312425	skin	malignant_melanoma	Substitution - coding silent
c.184G>A; p.E62K; 7:23468534-23468534	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.138C>T; p.D46D; 7:23469973-23469973	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.138C>T; p.D46D; 7:23469973-23469973	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.135G>A; p.P45P; 7:23469976-23469976	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1293T>G; p.L431L; 7:23319165-23319165	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1097C>T; p.P366L; 7:23342170-23342170	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.320T>G; p.V107G; 7:23361707-23361707	skin	malignant_melanoma	Substitution - Missense
c.1096C>T; p.P366S; 7:23342171-23342171	skin	malignant_melanoma	Substitution - Missense
c.1251C>T; p.V417V; 7:23319207-23319207	prostate	carcinoma	Substitution - coding silent
c.542G>T; p.R181M; 7:23351446-23351446	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1070C>T; p.S357F; 7:23343725-23343725	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.906T>C; p.I302I; 7:23345975-23345975	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.703G>T; p.E235*; 7:23347715-23347715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.469G>A; p.E157K; 7:23351519-23351519	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1508T>C; p.I503T; 7:23313541-23313541	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1508T>C; p.I503T; 7:23313541-23313541	pancreas	carcinoma	Substitution - Missense
c.1508T>C; p.I503T; 7:23313541-23313541	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.183A>T; p.I61I; 7:23468535-23468535	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.433G>C; p.E145Q; 7:23351555-23351555	skin	malignant_melanoma	Substitution - Missense
c.1526C>T; p.T509M; 7:23313523-23313523	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.541A>G; p.R181G; 7:23351447-23351447	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1194G>A; p.P398P; 7:23342073-23342073	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1037A>C; p.K346T; 7:23343758-23343758	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.646G>A; p.A216T; 7:23351342-23351342	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.904_905insA; p.I302fs*2; 7:23345976-23345977	liver	carcinoma	Insertion - Frameshift
c.18C>A; p.I6I; 7:23470093-23470093	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1732C>T; p.R578W; 7:23312370-23312370	breast	carcinoma	Substitution - Missense
c.423A>T; p.G141G; 7:23351565-23351565	skin	malignant_melanoma	Substitution - coding silent
c.938C>T; p.S313F; 7:23345943-23345943	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1408A>C; p.I470L; 7:23313641-23313641	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1077+6T>G; p.?; 7:23343712-23343712	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1023G>A; p.E341E; 7:23343772-23343772	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.338-2A>G; p.?; 7:23361599-23361599	stomach	carcinoma; adenocarcinoma	Unknown
c.338-2A>G; p.?; 7:23361599-23361599	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.184G>T; p.E62*; 7:23468534-23468534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1418A>C; p.K473T; 7:23313631-23313631	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1629C>A; p.F543L; 7:23312747-23312747	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1018G>C; p.E340Q; 7:23343777-23343777	urinary_tract; bladder	carcinoma	Substitution - Missense
c.698G>A; p.R233H; 7:23347720-23347720	pancreas	carcinoma	Substitution - Missense
c.607C>A; p.P203T; 7:23351381-23351381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.40G>A; p.A14T; 7:23470071-23470071	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1269G>C; p.K423N; 7:23319189-23319189	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1357A>C; p.M453L; 7:23317677-23317677	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.207A>T; p.E69D; 7:23468511-23468511	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.248T>G; p.L83R; 7:23418813-23418813	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.941C>T; p.P314L; 7:23345940-23345940	skin	malignant_melanoma	Substitution - Missense
c.941C>T; p.P314L; 7:23345940-23345940	pancreas	carcinoma	Substitution - Missense
c.553C>T; p.P185S; 7:23351435-23351435	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1550C>A; p.S517*; 7:23312826-23312826	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.203T>C; p.I68T; 7:23468515-23468515	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.612C>A; p.T204T; 7:23351376-23351376	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.626C>T; p.A209V; 7:23351362-23351362	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.879T>C; p.G293G; 7:23346002-23346002	stomach	adenocarcinoma	Substitution - coding silent
c.596G>A; p.R199H; 7:23351392-23351392	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.186A>G; p.E62E; 7:23468532-23468532	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1632T>C; p.Y544Y; 7:23312744-23312744	breast	carcinoma	Substitution - coding silent
c.729G>A; p.S243S; 7:23347689-23347689	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.478G>A; p.A160T; 7:23351510-23351510	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.840G>T; p.K280N; 7:23346041-23346041	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.912A>G; p.Q304Q; 7:23345969-23345969	kidney	other; neoplasm	Substitution - coding silent
c.1429G>T; p.E477*; 7:23313620-23313620	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1705C>A; p.L569M; 7:23312397-23312397	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.560C>T; p.S187F; 7:23351428-23351428	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.608C>T; p.P203L; 7:23351380-23351380	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.89C>G; p.S30W; 7:23470022-23470022	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.14A>G; p.Y5C; 7:23470097-23470097	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.900A>C; p.K300N; 7:23345981-23345981	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.211G>A; p.E71K; 7:23468507-23468507	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.211G>A; p.E71K; 7:23468507-23468507	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.211G>A; p.E71K; 7:23468507-23468507	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.211G>A; p.E71K; 7:23468507-23468507	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.211G>A; p.E71K; 7:23468507-23468507	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1422T>G; p.I474M; 7:23313627-23313627	liver	carcinoma	Substitution - Missense
c.1422T>G; p.I474M; 7:23313627-23313627	liver	carcinoma	Substitution - Missense
c.1422T>G; p.I474M; 7:23313627-23313627	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.635G>A; p.G212E; 7:23351353-23351353	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.942-2A>G; p.?; 7:23343855-23343855	oesophagus	carcinoma; adenocarcinoma	Unknown
c.635G>A; p.G212E; 7:23351353-23351353	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.719C>A; p.A240D; 7:23347699-23347699	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.693C>A; p.V231V; 7:23347725-23347725	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1208C>G; p.S403*; 7:23319250-23319250	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1527+2C>T; p.?; 7:23313520-23313520	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1387C>T; p.Q463*; 7:23317647-23317647	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.505C>T; p.R169*; 7:23351483-23351483	breast	carcinoma	Substitution - Nonsense
c.505C>T; p.R169*; 7:23351483-23351483	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.644G>T; p.G215V; 7:23351344-23351344	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1437T>C; p.F479F; 7:23313612-23313612	prostate	adenoma	Substitution - coding silent
c.313G>A; p.G105R; 7:23361714-23361714	skin	malignant_melanoma	Substitution - Missense
c.1239A>T; p.P413P; 7:23319219-23319219	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.443C>T; p.T148I; 7:23351545-23351545	skin	malignant_melanoma	Substitution - Missense
c.917C>T; p.T306I; 7:23345964-23345964	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1652G>T; p.R551I; 7:23312450-23312450	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.672G>T; p.Q224H; 7:23351316-23351316	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1182T>G; p.T394T; 7:23342085-23342085	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.680C>T; p.S227F; 7:23351308-23351308	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.314G>A; p.G105E; 7:23361713-23361713	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation