Cancer metastasis database

Annotation category 5

Gene information

Gene ID 10641
Symbol

NPRL2

Synonymous

NPR2|NPR2L|TUSC4

Full name

nitrogen permease regulator-like 2 (S. cerevisiae)

Gene description

2810446G01Rik|G21 protein|NPR2-like protein|gene 21 protein|homologous to yeast nitrogen permease (candidate tumor suppressor)|nitrogen permease regulator 2-like protein|tumor suppressor candidate 4

Cytoband

3p21.3

Gene type

protein-coding

Synonymous

MIM:607072; HGNC:HGNC:24969; Ensembl:ENSG00000114388; HPRD:06147; Vega:OTTHUMG00000156864

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.868C>A; p.P290T; 3:50348188-50348188

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.232C>T; p.R78C; 3:50349772-50349772

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.232C>T; p.R78C; 3:50349772-50349772

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.545A>T; p.E182V; 3:50348914-50348914

 prostatecarcinomaSubstitution - Missense

c.737G>A; p.C246Y; 3:50348394-50348394

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.899G>A; p.R300H; 3:50348157-50348157

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1057G>A; p.E353K; 3:50347777-50347777

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.969C>T; p.I323I; 3:50347865-50347865

 skinmalignant_melanomaSubstitution - coding silent

c.883C>T; p.R295*; 3:50348173-50348173

 oesophaguscarcinoma; adenocarcinomaSubstitution - Nonsense

c.883C>T; p.R295*; 3:50348173-50348173

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.295G>T; p.E99*; 3:50349709-50349709

 lungcarcinoma; small_cell_carcinomaSubstitution - Nonsense

c.376C>T; p.Q126*; 3:50349458-50349458

 ovaryother; neoplasmSubstitution - Nonsense

c.854A>G; p.Y285C; 3:50348202-50348202

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.987T>A; p.Y329*; 3:50347847-50347847

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.743C>G; p.T248R; 3:50348388-50348388

 soft_tissue; blood_vesselangiosarcomaSubstitution - Missense

c.836G>T; p.R279L; 3:50348220-50348220

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.116_117delCA; p.T39fs*51; 3:50349984-50349985

 central_nervous_system; brainglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.93C>T; p.F31F; 3:50350008-50350008

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.93C>T; p.F31F; 3:50350008-50350008

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.518A>T; p.D173V; 3:50348941-50348941

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.481G>C; p.E161Q; 3:50348978-50348978

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.609C>A; p.F203L; 3:50348759-50348759

 breastcarcinoma; ductal_carcinomaSubstitution - Missense

c.83C>T; p.P28L; 3:50350018-50350018

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.847C>T; p.Q283*; 3:50348209-50348209

 skinmalignant_melanomaSubstitution - Nonsense

c.907delC; p.Q303fs*11; 3:50348149-50348149

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.641_643delATG; p.D214delD; 3:50348725-50348727

 breastcarcinoma; basal_(triple-negative)_carcinomaDeletion - In frame

c.737G>T; p.C246F; 3:50348394-50348394

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.323A>C; p.Y108S; 3:50349681-50349681

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.476T>G; p.V159G; 3:50348983-50348983

 breastcarcinomaSubstitution - Missense

c.170+5G>T; p.?; 3:50349926-50349926

 large_intestine; rectumcarcinoma; adenocarcinomaUnknown

c.324T>C; p.Y108Y; 3:50349680-50349680

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.324T>C; p.Y108Y; 3:50349680-50349680

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.324T>C; p.Y108Y; 3:50349680-50349680

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.323A>T; p.Y108F; 3:50349681-50349681

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.673C>T; p.Q225*; 3:50348695-50348695

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.352T>G; p.F118V; 3:50349482-50349482

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.352T>G; p.F118V; 3:50349482-50349482

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.378G>A; p.Q126Q; 3:50349456-50349456

 pancreascarcinomaSubstitution - coding silent

c.364G>A; p.E122K; 3:50349470-50349470

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.354C>T; p.F118F; 3:50349480-50349480

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.214G>A; p.E72K; 3:50349790-50349790

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.931C>T; p.R311W; 3:50348125-50348125

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.931C>T; p.R311W; 3:50348125-50348125

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.267_268delTG; p.C89fs*1; 3:50349736-50349737

 lungcarcinoma; adenocarcinomaDeletion - Frameshift

c.948C>T; p.F316F; 3:50347886-50347886

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.562C>T; p.Q188*; 3:50348897-50348897

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Nonsense

c.355G>A; p.V119M; 3:50349479-50349479

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1102C>T; p.R368W; 3:50347647-50347647

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.684-3_684-2insTC; p.?; 3:50348565-50348566

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.684-3_684-2insTC; p.?; 3:50348565-50348566

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.448+1G>C; p.?; 3:50349385-50349385

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.710C>G; p.S237C; 3:50348537-50348537

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.518A>C; p.D173A; 3:50348941-50348941

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.807C>T; p.T269T; 3:50348324-50348324

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.595T>A; p.Y199N; 3:50348773-50348773

 pancreascarcinomaSubstitution - Missense

c.807C>T; p.T269T; 3:50348324-50348324

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.451G>A; p.E151K; 3:50349008-50349008

 thyroidcarcinomaSubstitution - Missense