lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10590
Symbol	SCGN
Synonymous	CALBL\|DJ501N12.8\|SECRET\|SEGN\|setagin
Full name	secretagogin, EF-hand calcium binding protein
Gene description	secretagogin
Cytoband	6p22.3-p22.1
Gene type	protein-coding
Synonymous	MIM:609202; HGNC:HGNC:16941; Ensembl:ENSG00000079689; HPRD:10211; Vega:OTTHUMG00000014409

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.301G>A; p.E101K; 6:25664997-25664997	skin	malignant_melanoma	Substitution - Missense
c.153+1G>C; p.?; 6:25653453-25653453	lung	carcinoma; adenocarcinoma	Unknown
c.481T>G; p.F161V; 6:25681960-25681960	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.502C>T; p.R168W; 6:25681981-25681981	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.672G>T; p.G224G; 6:25691094-25691094	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.737G>T; p.R246L; 6:25701241-25701241	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.323T>C; p.V108A; 6:25665019-25665019	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.296G>A; p.R99H; 6:25664992-25664992	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.295C>T; p.R99C; 6:25664991-25664991	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.295C>T; p.R99C; 6:25664991-25664991	skin	malignant_melanoma	Substitution - Missense
c.737G>A; p.R246H; 6:25701241-25701241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.393+10A>T; p.?; 6:25669577-25669577	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.661G>A; p.E221K; 6:25691083-25691083	liver	carcinoma	Substitution - Missense
c.349T>A; p.Y117N; 6:25669523-25669523	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.661G>A; p.E221K; 6:25691083-25691083	liver	carcinoma	Substitution - Missense
c.827C>A; p.P276Q; 6:25701331-25701331	pancreas	NS	Substitution - Missense
c.246G>T; p.E82D; 6:25661644-25661644	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.401T>A; p.L134H; 6:25670006-25670006	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.235C>T; p.R79W; 6:25661633-25661633	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.67C>T; p.R23C; 6:25652470-25652470	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.186G>T; p.V62V; 6:25661584-25661584	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.752G>A; p.R251H; 6:25701256-25701256	breast	carcinoma	Substitution - Missense
c.151G>T; p.D51Y; 6:25653450-25653450	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.54G>C; p.W18C; 6:25652457-25652457	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.336G>A; p.Q112Q; 6:25665032-25665032	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.559C>T; p.Q187*; 6:25689203-25689203	skin	malignant_melanoma	Substitution - Nonsense
c.559C>T; p.Q187*; 6:25689203-25689203	skin	malignant_melanoma	Substitution - Nonsense
c.240G>A; p.M80I; 6:25661638-25661638	skin	malignant_melanoma	Substitution - Missense
c.594G>C; p.R198S; 6:25689493-25689493	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.486C>G; p.D162E; 6:25681965-25681965	central_nervous_system; brain	glioma	Substitution - Missense
c.822C>A; p.I274I; 6:25701326-25701326	breast	carcinoma	Substitution - coding silent
c.609G>A; p.E203E; 6:25689508-25689508	skin	malignant_melanoma	Substitution - coding silent
c.508G>A; p.D170N; 6:25681987-25681987	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.403C>A; p.R135R; 6:25670008-25670008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.530T>C; p.I177T; 6:25689174-25689174	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.229C>T; p.R77C; 6:25661627-25661627	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.279C>G; p.N93K; 6:25664975-25664975	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.483T>C; p.F161F; 6:25681962-25681962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.112G>A; p.D38N; 6:25653411-25653411	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.571G>A; p.D191N; 6:25689215-25689215	skin	malignant_melanoma	Substitution - Missense
c.615C>G; p.I205M; 6:25689514-25689514	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.741G>T; p.E247D; 6:25701245-25701245	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.765G>A; p.V255V; 6:25701269-25701269	skin	malignant_melanoma	Substitution - coding silent
c.312G>A; p.L104L; 6:25665008-25665008	skin	malignant_melanoma	Substitution - coding silent
c.780A>T; p.K260N; 6:25701284-25701284	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.261C>A; p.F87L; 6:25664957-25664957	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.334C>G; p.Q112E; 6:25665030-25665030	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.399C>T; p.F133F; 6:25670004-25670004	skin	malignant_melanoma	Substitution - coding silent
c.399C>T; p.F133F; 6:25670004-25670004	skin	malignant_melanoma	Substitution - coding silent
c.399C>T; p.F133F; 6:25670004-25670004	skin	malignant_melanoma	Substitution - coding silent
c.776G>A; p.G259E; 6:25701280-25701280	skin	malignant_melanoma	Substitution - Missense
c.297C>T; p.R99R; 6:25664993-25664993	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.289C>T; p.L97F; 6:25664985-25664985	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.589G>T; p.E197*; 6:25689488-25689488	skin	malignant_melanoma	Substitution - Nonsense
c.760G>A; p.D254N; 6:25701264-25701264	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.760G>A; p.D254N; 6:25701264-25701264	NS	malignant_melanoma	Substitution - Missense
c.760G>A; p.D254N; 6:25701264-25701264	NS	malignant_melanoma	Substitution - Missense
c.405A>G; p.R135R; 6:25670010-25670010	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.403C>T; p.R135*; 6:25670008-25670008	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.403C>T; p.R135*; 6:25670008-25670008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.579T>C; p.C193C; 6:25689478-25689478	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.403C>T; p.R135*; 6:25670008-25670008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.433A>C; p.I145L; 6:25670038-25670038	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.745C>A; p.L249I; 6:25701249-25701249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.774T>C; p.D258D; 6:25701278-25701278	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.298C>T; p.R100W; 6:25664994-25664994	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.795G>A; p.E265E; 6:25701299-25701299	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.715G>T; p.G239W; 6:25701219-25701219	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.324G>T; p.V108V; 6:25665020-25665020	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.344G>A; p.R115H; 6:25669518-25669518	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.390C>A; p.L130L; 6:25669564-25669564	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.404G>A; p.R135Q; 6:25670009-25670009	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.404G>A; p.R135Q; 6:25670009-25670009	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.404G>T; p.R135L; 6:25670009-25670009	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.299G>A; p.R100Q; 6:25664995-25664995	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.216C>A; p.A72A; 6:25661614-25661614	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.807T>C; p.C269C; 6:25701311-25701311	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.322G>A; p.V108M; 6:25665018-25665018	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.322G>A; p.V108M; 6:25665018-25665018	urinary_tract; bladder	carcinoma	Substitution - Missense
c.322G>A; p.V108M; 6:25665018-25665018	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.731A>T; p.K244M; 6:25701235-25701235	prostate	carcinoma	Substitution - Missense
c.327G>T; p.E109D; 6:25665023-25665023	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.230G>A; p.R77H; 6:25661628-25661628	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.230G>A; p.R77H; 6:25661628-25661628	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.528-1G>T; p.?; 6:25689171-25689171	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.377C>T; p.S126L; 6:25669551-25669551	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.411C>G; p.L137L; 6:25670016-25670016	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.411C>G; p.L137L; 6:25670016-25670016	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.232A>C; p.I78L; 6:25661630-25661630	pancreas	carcinoma	Substitution - Missense
c.133T>C; p.L45L; 6:25653432-25653432	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.431C>T; p.A144V; 6:25670036-25670036	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.258G>A; p.M86I; 6:25664954-25664954	urinary_tract; bladder	carcinoma	Substitution - Missense
c.544G>A; p.E182K; 6:25689188-25689188	skin; extremity	malignant_melanoma	Substitution - Missense
c.738C>T; p.R246R; 6:25701242-25701242	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.552C>T; p.F184F; 6:25689196-25689196	skin	malignant_melanoma	Substitution - coding silent
c.442G>T; p.A148S; 6:25670047-25670047	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274G>A; p.E92K; 6:25664970-25664970	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation