lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10562
Symbol	OLFM4
Synonymous	GC1\|GW112\|OLM4\|OlfD\|UNQ362\|bA209J19.1\|hGC-1\|hOLfD
Full name	olfactomedin 4
Gene description	G-CSF-stimulated clone 1 protein\|antiapoptotic protein GW112\|olfactomedin-4
Cytoband	13q14.3
Gene type	protein-coding
Synonymous	MIM:614061; HGNC:HGNC:17190; Ensembl:ENSG00000102837; HPRD:06580; Vega:OTTHUMG00000016981

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1483G>A; p.D495N; 13:53050721-53050721	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1483G>A; p.D495N; 13:53050721-53050721	skin	malignant_melanoma	Substitution - Missense
c.1326C>T; p.A442A; 13:53050564-53050564	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1145A>G; p.D382G; 13:53050383-53050383	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.205-4G>A; p.?; 13:53034344-53034344	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.643G>T; p.E215*; 13:53043177-53043177	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.374_377delAATT; p.I127fs*8; 13:53041926-53041929	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1298C>T; p.A433V; 13:53050536-53050536	skin	malignant_melanoma	Substitution - Missense
c.67G>A; p.G23R; 13:53028903-53028903	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.718C>T; p.P240S; 13:53043252-53043252	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.725C>T; p.T242I; 13:53043259-53043259	skin; mucosal	malignant_melanoma	Substitution - Missense
c.533G>T; p.G178V; 13:53042085-53042085	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.202C>A; p.Q68K; 13:53029038-53029038	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.533G>T; p.G178V; 13:53042085-53042085	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.777G>T; p.V259V; 13:53050015-53050015	breast	carcinoma	Substitution - coding silent
c.1005C>A; p.N335K; 13:53050243-53050243	breast	carcinoma	Substitution - Missense
c.1296C>T; p.N432N; 13:53050534-53050534	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.12C>T; p.G4G; 13:53028848-53028848	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1141C>G; p.Q381E; 13:53050379-53050379	urinary_tract; bladder	carcinoma	Substitution - Missense
c.462G>A; p.L154L; 13:53042014-53042014	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - coding silent
c.22C>A; p.L8I; 13:53028858-53028858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.631G>T; p.A211S; 13:53043165-53043165	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1035C>T; p.T345T; 13:53050273-53050273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.11G>A; p.G4D; 13:53028847-53028847	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1286C>A; p.S429Y; 13:53050524-53050524	breast	carcinoma	Substitution - Missense
c.358-1G>T; p.?; 13:53041909-53041909	lung	carcinoma; adenocarcinoma	Unknown
c.1450A>C; p.N484H; 13:53050688-53050688	pancreas	carcinoma	Substitution - Missense
c.744T>C; p.H248H; 13:53049982-53049982	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.46G>T; p.G16C; 13:53028882-53028882	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1321T>C; p.Y441H; 13:53050559-53050559	stomach	adenocarcinoma	Substitution - Missense
c.505C>T; p.L169L; 13:53042057-53042057	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.946A>T; p.I316L; 13:53050184-53050184	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1038G>A; p.G346G; 13:53050276-53050276	skin; leg	malignant_melanoma	Substitution - coding silent
c.1038G>A; p.G346G; 13:53050276-53050276	skin; leg	malignant_melanoma	Substitution - coding silent
c.993A>C; p.T331T; 13:53050231-53050231	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1512T>A; p.S504S; 13:53050750-53050750	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.346G>T; p.E116*; 13:53034489-53034489	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.229G>T; p.V77L; 13:53034372-53034372	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.229G>T; p.V77L; 13:53034372-53034372	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.656T>C; p.L219P; 13:53043190-53043190	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.570G>T; p.E190D; 13:53042122-53042122	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.325C>A; p.L109I; 13:53034468-53034468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1432G>C; p.V478L; 13:53050670-53050670	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.204G>T; p.Q68H; 13:53029040-53029040	ovary	carcinoma	Substitution - Missense
c.989G>A; p.G330D; 13:53050227-53050227	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1404_1405insATTGTA; p.V470_M471insIV; 13:53050642-53050643	oesophagus	carcinoma; adenocarcinoma	Insertion - In frame
c.1469T>G; p.L490R; 13:53050707-53050707	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.699C>T; p.N233N; 13:53043233-53043233	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1244T>G; p.L415R; 13:53050482-53050482	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1281A>G; p.K427K; 13:53050519-53050519	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1349C>A; p.T450K; 13:53050587-53050587	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1037G>A; p.G346E; 13:53050275-53050275	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.925C>A; p.L309M; 13:53050163-53050163	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.284C>A; p.P95H; 13:53034427-53034427	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.586C>T; p.L196F; 13:53043120-53043120	skin	malignant_melanoma	Substitution - Missense
c.778G>C; p.V260L; 13:53050016-53050016	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1401A>G; p.L467L; 13:53050639-53050639	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.232G>A; p.D78N; 13:53034375-53034375	breast	carcinoma	Substitution - Missense
c.1344C>A; p.T448T; 13:53050582-53050582	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.39C>T; p.F13F; 13:53028875-53028875	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.642A>T; p.R214R; 13:53043176-53043176	kidney	other; neoplasm	Substitution - coding silent
c.396G>T; p.K132N; 13:53041948-53041948	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.396G>T; p.K132N; 13:53041948-53041948	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.254G>A; p.C85Y; 13:53034397-53034397	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1511C>T; p.S504F; 13:53050749-53050749	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1263G>A; p.W421*; 13:53050501-53050501	skin	malignant_melanoma	Substitution - Nonsense
c.173G>A; p.R58H; 13:53029009-53029009	central_nervous_system; brain	glioma	Substitution - Missense
c.974A>T; p.Y325F; 13:53050212-53050212	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1156G>T; p.A386S; 13:53050394-53050394	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1356G>T; p.E452D; 13:53050594-53050594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1356G>T; p.E452D; 13:53050594-53050594	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.381T>C; p.I127I; 13:53041933-53041933	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.873G>A; p.A291A; 13:53050111-53050111	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1319T>C; p.L440P; 13:53050557-53050557	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1386G>A; p.G462G; 13:53050624-53050624	skin	malignant_melanoma	Substitution - coding silent
c.861G>T; p.L287L; 13:53050099-53050099	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.893G>A; p.R298K; 13:53050131-53050131	breast	carcinoma	Substitution - Missense
c.1385G>T; p.G462V; 13:53050623-53050623	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1202G>A; p.S401N; 13:53050440-53050440	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1150G>T; p.D384Y; 13:53050388-53050388	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.964C>T; p.R322W; 13:53050202-53050202	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.224G>T; p.G75V; 13:53034367-53034367	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.153G>A; p.R51R; 13:53028989-53028989	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.409C>G; p.L137V; 13:53041961-53041961	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.285C>A; p.P95P; 13:53034428-53034428	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.868G>T; p.V290L; 13:53050106-53050106	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.704C>T; p.P235L; 13:53043238-53043238	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.59G>T; p.G20V; 13:53028895-53028895	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1121C>T; p.S374L; 13:53050359-53050359	skin	malignant_melanoma	Substitution - Missense
c.469G>A; p.E157K; 13:53042021-53042021	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1121C>T; p.S374L; 13:53050359-53050359	skin; abdomen	malignant_melanoma	Substitution - Missense
c.178T>C; p.L60L; 13:53029014-53029014	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.263C>T; p.S88F; 13:53034406-53034406	skin	malignant_melanoma	Substitution - Missense
c.22C>T; p.L8F; 13:53028858-53028858	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.632C>T; p.A211V; 13:53043166-53043166	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.786C>T; p.L262L; 13:53050024-53050024	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.15C>T; p.L5L; 13:53028851-53028851	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.364G>T; p.E122*; 13:53041916-53041916	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Nonsense
c.685T>A; p.S229T; 13:53043219-53043219	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1159G>T; p.V387L; 13:53050397-53050397	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.238C>T; p.R80C; 13:53034381-53034381	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.238C>T; p.R80C; 13:53034381-53034381	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.889G>A; p.G297R; 13:53050127-53050127	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.34C>T; p.L12L; 13:53028870-53028870	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1404C>G; p.D468E; 13:53050642-53050642	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1495C>T; p.L499L; 13:53050733-53050733	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.978C>T; p.G326G; 13:53050216-53050216	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.931G>A; p.D311N; 13:53050169-53050169	skin	malignant_melanoma	Substitution - Missense
c.585T>C; p.T195T; 13:53043119-53043119	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.423T>A; p.I141I; 13:53041975-53041975	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.348_349delAC; p.E116fs*12; 13:53034491-53034492	pancreas	carcinoma; ductal_carcinoma	Deletion - Frameshift
c.1275G>T; p.Q425H; 13:53050513-53050513	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1300T>C; p.F434L; 13:53050538-53050538	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1464G>A; p.Q488Q; 13:53050702-53050702	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.77G>T; p.G26V; 13:53028913-53028913	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.962T>C; p.L321S; 13:53050200-53050200	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1454C>A; p.P485H; 13:53050692-53050692	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.213C>T; p.S71S; 13:53034356-53034356	skin	malignant_melanoma	Substitution - coding silent
c.1061C>A; p.T354N; 13:53050299-53050299	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1515C>A; p.V505V; 13:53050753-53050753	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.499G>A; p.E167K; 13:53042051-53042051	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1132G>A; p.V378I; 13:53050370-53050370	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1092C>T; p.L364L; 13:53050330-53050330	skin	malignant_melanoma	Substitution - coding silent
c.1346G>A; p.R449K; 13:53050584-53050584	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1525delC; p.Q510fs?; 13:53050763-53050763	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Deletion - Frameshift
c.354C>T; p.S118S; 13:53034497-53034497	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1001A>G; p.Y334C; 13:53050239-53050239	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.735C>A; p.S245R; 13:53049973-53049973	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.822G>A; p.W274*; 13:53050060-53050060	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.36G>C; p.L12L; 13:53028872-53028872	kidney	other; neoplasm	Substitution - coding silent
c.155C>A; p.S52*; 13:53028991-53028991	oesophagus	carcinoma	Substitution - Nonsense
c.10G>T; p.G4C; 13:53028846-53028846	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.10G>T; p.G4C; 13:53028846-53028846	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.843G>T; p.Q281H; 13:53050081-53050081	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1114C>A; p.R372S; 13:53050352-53050352	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1516T>A; p.L506M; 13:53050754-53050754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1114C>A; p.R372S; 13:53050352-53050352	pancreas	carcinoma	Substitution - Missense
c.1114C>A; p.R372S; 13:53050352-53050352	pancreas	carcinoma	Substitution - Missense
c.1114C>A; p.R372S; 13:53050352-53050352	breast	carcinoma	Substitution - Missense
c.956G>A; p.R319Q; 13:53050194-53050194	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1217T>C; p.V406A; 13:53050455-53050455	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.116G>T; p.G39V; 13:53028952-53028952	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.648C>T; p.I216I; 13:53043182-53043182	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.586C>A; p.L196I; 13:53043120-53043120	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.293G>A; p.R98K; 13:53034436-53034436	skin	malignant_melanoma	Substitution - Missense
c.47G>T; p.G16V; 13:53028883-53028883	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.145A>T; p.S49C; 13:53028981-53028981	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.203A>T; p.Q68L; 13:53029039-53029039	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1096A>T; p.N366Y; 13:53050334-53050334	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.364G>A; p.E122K; 13:53041916-53041916	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.965G>A; p.R322Q; 13:53050203-53050203	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.903G>C; p.E301D; 13:53050141-53050141	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.709G>A; p.V237I; 13:53043243-53043243	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.60G>A; p.G20G; 13:53028896-53028896	skin	malignant_melanoma	Substitution - coding silent
c.96C>T; p.P32P; 13:53028932-53028932	breast	carcinoma	Substitution - coding silent
c.533G>A; p.G178D; 13:53042085-53042085	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.89C>T; p.P30L; 13:53028925-53028925	skin	malignant_melanoma	Substitution - Missense
c.1182T>A; p.V394V; 13:53050420-53050420	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.964C>A; p.R322R; 13:53050202-53050202	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.803C>T; p.S268F; 13:53050041-53050041	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation